UA127305C2 - Злитий серпіновий поліпептид і спосіб його застосування - Google Patents
Злитий серпіновий поліпептид і спосіб його застосування Download PDFInfo
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- UA127305C2 UA127305C2 UAA201705128A UAA201705128A UA127305C2 UA 127305 C2 UA127305 C2 UA 127305C2 UA A201705128 A UAA201705128 A UA A201705128A UA A201705128 A UAA201705128 A UA A201705128A UA 127305 C2 UA127305 C2 UA 127305C2
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Virology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/524,832 US10400029B2 (en) | 2011-06-28 | 2014-10-27 | Serpin fusion polypeptides and methods of use thereof |
| PCT/US2015/057533 WO2016069574A1 (en) | 2014-10-27 | 2015-10-27 | Serpin fusion polypeptides and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA127305C2 true UA127305C2 (uk) | 2023-07-19 |
Family
ID=55858243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201705128A UA127305C2 (uk) | 2014-10-27 | 2015-10-27 | Злитий серпіновий поліпептид і спосіб його застосування |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP3212290A4 (ko) |
| JP (2) | JP6737781B2 (ko) |
| KR (2) | KR20240005109A (ko) |
| CN (2) | CN107206257A (ko) |
| AU (2) | AU2015339507B2 (ko) |
| BR (1) | BR112017008525A2 (ko) |
| CA (1) | CA2965151A1 (ko) |
| HK (1) | HK1244460A1 (ko) |
| IL (2) | IL308589A (ko) |
| MX (2) | MX2017005467A (ko) |
| RU (1) | RU2746550C2 (ko) |
| SG (2) | SG10201903142RA (ko) |
| UA (1) | UA127305C2 (ko) |
| WO (1) | WO2016069574A1 (ko) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020092448A1 (en) * | 2018-10-29 | 2020-05-07 | Spin Therapeutics, Llc | Compositions and methods for alpha-1-antitrypsin disorders |
| WO2020097946A1 (zh) * | 2018-11-18 | 2020-05-22 | 杭州博虎生物科技有限公司 | 一种重组人白细胞介素10融合蛋白及其应用 |
| CN112315897A (zh) * | 2020-11-04 | 2021-02-05 | 深圳前海鹰岗生物科技有限公司 | 一种抑制细胞炎症反应释放治疗痛风急性发作的聚合物微针及制备方法 |
| US20240067703A1 (en) * | 2020-12-21 | 2024-02-29 | Macquarie University | Treatment of glaucoma |
| GB202102258D0 (en) | 2021-02-17 | 2021-03-31 | Arecor Ltd | Novel composition |
| CA3205815A1 (en) * | 2021-03-03 | 2022-09-09 | Alwin REITER | Formulations of ace2 fc fusion proteins |
| CN113325181A (zh) * | 2021-04-25 | 2021-08-31 | 苏州市立医院(北区) | 丝氨酸蛋白酶抑制剂在用于脓毒症早期预警的标志物中的应用 |
| CN114874333A (zh) * | 2021-10-18 | 2022-08-09 | 深圳科兴药业有限公司 | 一种生长激素融合蛋白及其应用 |
| US20230364208A1 (en) | 2022-05-16 | 2023-11-16 | Inhibrx, Inc. | Effective dosage of recombinant serpin-fc fusion protein for use in a method of treating aat deficiency in a subject |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
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| AU3609300A (en) * | 1999-03-01 | 2000-09-21 | Human Genome Sciences, Inc. | Human serpin proteins |
| US7317091B2 (en) * | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| US7217797B2 (en) * | 2002-10-15 | 2007-05-15 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| EP1646642A2 (en) * | 2003-07-18 | 2006-04-19 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
| PL2520654T3 (pl) * | 2003-08-26 | 2017-08-31 | The Regents Of The University Of Colorado, A Body Corporate | Inhibitory aktywności proteazy serynowej i ich zastosowanie w sposobach i kompozycjach do leczenia zakażeń bakteryjnych |
| US8802820B2 (en) * | 2004-11-12 | 2014-08-12 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| EP2332985A3 (en) * | 2004-11-12 | 2012-01-25 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| DE602006010874D1 (de) * | 2005-07-22 | 2010-01-14 | Five Prime Therapeutics Inc | Zusammensetzungen und verfahren zur behandlung von krankheiten mit fgfr-fusionsproteinen |
| CA2618951A1 (en) * | 2005-08-12 | 2007-02-22 | Schering Corporation | Mcp1 fusions |
| EP2307456B1 (en) * | 2008-06-27 | 2014-10-15 | Amgen Inc. | Ang-2 inhibition to treat multiple sclerosis |
| RU2593720C2 (ru) * | 2008-12-19 | 2016-08-10 | Макродженикс, Инк. | Ковалентные диантитела и их применение |
| PT2654780T (pt) * | 2010-12-23 | 2017-04-06 | Janssen Biotech Inc | Mutantes ativos de fc de anticorpos resistentes a proteases |
| ES2692268T3 (es) * | 2011-03-29 | 2018-12-03 | Roche Glycart Ag | Variantes de Fc de anticuerpo |
| IN2013MN02441A (ko) * | 2011-06-28 | 2015-06-12 | Inhibrx Llc | |
| KR20140068861A (ko) * | 2011-06-28 | 2014-06-09 | 인히브릭스 엘엘씨 | Wap 도메인 융합 폴리펩티드 및 이의 이용 방법 |
| KR20140137347A (ko) * | 2012-01-10 | 2014-12-02 | 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 | 알파-1 안티트립신 융합 분자용 조성물, 방법 및 용도 |
| EP2863954A1 (en) * | 2012-06-21 | 2015-04-29 | Indiana University Research and Technology Corporation | Incretin receptor ligand polypeptide fc-region fusion polypeptides and conjugates with altered fc-effector function |
| EP2867254B1 (en) * | 2012-06-27 | 2017-10-25 | F. Hoffmann-La Roche AG | Method for making antibody fc-region conjugates comprising at least one binding entity that specifically binds to a target and uses thereof |
| ES2602030T3 (es) * | 2012-08-02 | 2017-02-17 | F. Hoffmann-La Roche Ag | Método para producir RFc solubles como fusión de Fc con la región Fc de inmunoglobulina inerte y usos de los mismos |
| CA2893359C (en) * | 2012-12-05 | 2021-12-28 | Strategia Therapeutics, Inc. | Protein expression enhancing polypeptides |
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2015
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- 2015-10-27 SG SG10201903142RA patent/SG10201903142RA/en unknown
- 2015-10-27 CN CN201580071331.7A patent/CN107206257A/zh active Pending
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- 2015-10-27 CA CA2965151A patent/CA2965151A1/en active Pending
- 2015-10-27 JP JP2017522654A patent/JP6737781B2/ja active Active
- 2015-10-27 IL IL308589A patent/IL308589A/en unknown
- 2015-10-27 CN CN202111439584.9A patent/CN114316068A/zh active Pending
- 2015-10-27 SG SG11201703390SA patent/SG11201703390SA/en unknown
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- 2015-10-27 IL IL251799A patent/IL251799B2/en unknown
- 2015-10-27 KR KR1020177014414A patent/KR20170091096A/ko not_active IP Right Cessation
- 2015-10-27 EP EP15854670.5A patent/EP3212290A4/en active Pending
- 2015-10-27 AU AU2015339507A patent/AU2015339507B2/en active Active
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- 2015-10-27 RU RU2017118325A patent/RU2746550C2/ru active
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Also Published As
| Publication number | Publication date |
|---|---|
| BR112017008525A2 (pt) | 2018-01-30 |
| JP2020180157A (ja) | 2020-11-05 |
| SG10201903142RA (en) | 2019-05-30 |
| SG11201703390SA (en) | 2017-05-30 |
| IL251799B2 (en) | 2024-04-01 |
| CN107206257A (zh) | 2017-09-26 |
| AU2015339507A1 (en) | 2017-05-11 |
| WO2016069574A1 (en) | 2016-05-06 |
| EP3212290A4 (en) | 2019-01-23 |
| CN114316068A (zh) | 2022-04-12 |
| AU2015339507B2 (en) | 2021-07-01 |
| IL308589A (en) | 2024-01-01 |
| HK1244460A1 (zh) | 2018-08-10 |
| CA2965151A1 (en) | 2016-05-06 |
| MX2021012047A (es) | 2021-11-03 |
| RU2746550C2 (ru) | 2021-04-15 |
| AU2021240153A1 (en) | 2021-10-28 |
| JP2017537888A (ja) | 2017-12-21 |
| MX2017005467A (es) | 2017-11-30 |
| EP3212290A1 (en) | 2017-09-06 |
| KR20170091096A (ko) | 2017-08-08 |
| IL251799A0 (en) | 2017-06-29 |
| RU2017118325A3 (ko) | 2019-03-21 |
| KR20240005109A (ko) | 2024-01-11 |
| IL251799B1 (en) | 2023-12-01 |
| JP6737781B2 (ja) | 2020-08-12 |
| RU2017118325A (ru) | 2018-11-29 |
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