AU2015339507B2 - Serpin fusion polypeptides and methods of use thereof - Google Patents
Serpin fusion polypeptides and methods of use thereof Download PDFInfo
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- AU2015339507B2 AU2015339507B2 AU2015339507A AU2015339507A AU2015339507B2 AU 2015339507 B2 AU2015339507 B2 AU 2015339507B2 AU 2015339507 A AU2015339507 A AU 2015339507A AU 2015339507 A AU2015339507 A AU 2015339507A AU 2015339507 B2 AU2015339507 B2 AU 2015339507B2
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
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- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
Landscapes
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| AU2021240153A AU2021240153A1 (en) | 2014-10-27 | 2021-09-28 | Serpin fusion polypeptides and methods of use thereof |
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| US14/524,832 US10400029B2 (en) | 2011-06-28 | 2014-10-27 | Serpin fusion polypeptides and methods of use thereof |
| PCT/US2015/057533 WO2016069574A1 (en) | 2014-10-27 | 2015-10-27 | Serpin fusion polypeptides and methods of use thereof |
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| JP (2) | JP6737781B2 (ko) |
| KR (2) | KR20240005109A (ko) |
| CN (2) | CN114316068A (ko) |
| AU (2) | AU2015339507B2 (ko) |
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| KR20210111245A (ko) * | 2018-10-29 | 2021-09-10 | 스핀 테라퓨틱스, 엘엘씨 | 알파-1-항트립신 장애들을 위한 조성물들 및 방법들 |
| CN111989340A (zh) * | 2018-11-18 | 2020-11-24 | 杭州博虎生物科技有限公司 | 一种重组人白细胞介素10融合蛋白及其应用 |
| CN112315897A (zh) * | 2020-11-04 | 2021-02-05 | 深圳前海鹰岗生物科技有限公司 | 一种抑制细胞炎症反应释放治疗痛风急性发作的聚合物微针及制备方法 |
| US20240067703A1 (en) * | 2020-12-21 | 2024-02-29 | Macquarie University | Treatment of glaucoma |
| GB202102258D0 (en) | 2021-02-17 | 2021-03-31 | Arecor Ltd | Novel composition |
| AU2022230745A1 (en) * | 2021-03-03 | 2023-08-17 | Formycon Ag | Formulations of ace2 fc fusion proteins |
| CN113325181A (zh) * | 2021-04-25 | 2021-08-31 | 苏州市立医院(北区) | 丝氨酸蛋白酶抑制剂在用于脓毒症早期预警的标志物中的应用 |
| CN114874333A (zh) * | 2021-10-18 | 2022-08-09 | 深圳科兴药业有限公司 | 一种生长激素融合蛋白及其应用 |
| US20230364208A1 (en) | 2022-05-16 | 2023-11-16 | Inhibrx, Inc. | Effective dosage of recombinant serpin-fc fusion protein for use in a method of treating aat deficiency in a subject |
Citations (2)
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| US20060173170A1 (en) * | 2004-11-12 | 2006-08-03 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| US20130011398A1 (en) * | 2011-06-28 | 2013-01-10 | Inhibrx Llc | Serpin Fusion Polypeptides and Methods of Use Thereof |
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| CA2364471A1 (en) * | 1999-03-01 | 2000-09-08 | Human Genome Sciences, Inc. | Human serpin proteins |
| US7317091B2 (en) * | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| US7217797B2 (en) * | 2002-10-15 | 2007-05-15 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| CN1852920B (zh) * | 2003-07-18 | 2010-12-15 | 沃泰克斯药物股份有限公司 | 丝氨酸蛋白酶抑制剂、特别是hcv ns3-ns4a蛋白酶抑制剂 |
| US7850970B2 (en) * | 2003-08-26 | 2010-12-14 | The Regents Of The University Of Colorado | Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections |
| US8802820B2 (en) * | 2004-11-12 | 2014-08-12 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| CA2614039C (en) * | 2005-07-22 | 2015-10-13 | Five Prime Therapeutics, Inc. | Compositions and methods of treating disease with fgfr fusion proteins |
| AU2006280004A1 (en) * | 2005-08-12 | 2007-02-22 | Schering Corporation | MCP1 fusions |
| AU2009262199B2 (en) * | 2008-06-27 | 2012-08-09 | Amgen Inc. | Ang-2 inhibition to treat multiple sclerosis |
| KR101940059B1 (ko) * | 2008-12-19 | 2019-01-18 | 마크로제닉스, 인크. | 공유결합형 디아바디 및 이의 용도 |
| DK2654780T3 (en) * | 2010-12-23 | 2017-04-10 | Janssen Biotech Inc | ACTIVE PROTEASE-RESISTANT ANTIBODY-FC MUTANTS |
| ES2692268T3 (es) * | 2011-03-29 | 2018-12-03 | Roche Glycart Ag | Variantes de Fc de anticuerpo |
| AU2012275295B2 (en) * | 2011-06-28 | 2016-11-10 | Inhibrx, Lp | WAP domain fusion polypeptides and methods of use thereof |
| JP2015504675A (ja) * | 2012-01-10 | 2015-02-16 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイトＴＨＥ ＲＥＧＥＮＴＳ ＯＦ ＴＨＥ ＵＮＩＶＥＲＳＩＴＹ ＯＦ ＣＯＬＯＲＡＤＯ，ａ ｂｏｄｙ ｃｏｒｐｏｒａｔｅ | アルファ−１アンチトリプシン融合分子の組成物、方法、及び使用 |
| CN104582736A (zh) * | 2012-06-21 | 2015-04-29 | 印第安纳大学研究及科技有限公司 | Fc效应子功能改变的肠降血糖素受体配体多肽Fc区融合多肽和缀合物 |
| WO2014001325A1 (en) * | 2012-06-27 | 2014-01-03 | F. Hoffmann-La Roche Ag | Method for making antibody fc-region conjugates comprising at least one binding entity that specifically binds to a target and uses thereof |
| PL2880170T3 (pl) * | 2012-08-02 | 2017-02-28 | F.Hoffmann-La Roche Ag | SPOSÓB WYTWARZANIA ROZPUSZCZALNEGO FcR JAKO FUZJI Fc Z OBOJĘTNYM REGIONEM Fc IMMUNOGLOBULINY I JEGO ZASTOSOWANIA |
| JP6345688B2 (ja) * | 2012-12-05 | 2018-06-20 | ソラ・バイオサイエンシズ・エルエルシー | タンパク質発現増強ポリペプチド |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060173170A1 (en) * | 2004-11-12 | 2006-08-03 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| US20130011398A1 (en) * | 2011-06-28 | 2013-01-10 | Inhibrx Llc | Serpin Fusion Polypeptides and Methods of Use Thereof |
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| CN107206257A (zh) | 2017-09-26 |
| JP6737781B2 (ja) | 2020-08-12 |
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| SG11201703390SA (en) | 2017-05-30 |
| MX2017005467A (es) | 2017-11-30 |
| AU2021240153A1 (en) | 2021-10-28 |
| KR20170091096A (ko) | 2017-08-08 |
| SG10201903142RA (en) | 2019-05-30 |
| EP3212290A4 (en) | 2019-01-23 |
| RU2746550C2 (ru) | 2021-04-15 |
| AU2015339507A1 (en) | 2017-05-11 |
| UA127305C2 (uk) | 2023-07-19 |
| WO2016069574A1 (en) | 2016-05-06 |
| MX2021012047A (es) | 2021-11-03 |
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| IL251799B2 (en) | 2024-04-01 |
| IL251799B1 (en) | 2023-12-01 |
| CN114316068A (zh) | 2022-04-12 |
| CA2965151A1 (en) | 2016-05-06 |
| JP2017537888A (ja) | 2017-12-21 |
| IL308589A (en) | 2024-01-01 |
| JP2020180157A (ja) | 2020-11-05 |
| EP3212290A1 (en) | 2017-09-06 |
| HK1244460A1 (zh) | 2018-08-10 |
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| AU2012275295B2 (en) | WAP domain fusion polypeptides and methods of use thereof | |
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| HB | Alteration of name in register |
Owner name: INHIBRX, LP Free format text: FORMER NAME(S): INHIBRX LP |
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| PC1 | Assignment before grant (sect. 113) |
Owner name: INHIBRX, INC. Free format text: FORMER APPLICANT(S): INHIBRX, LP |
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| FGA | Letters patent sealed or granted (standard patent) |