UA126582C2 - Кристалічна форма n-[1-(5-ціанопіридин-2-ілметил)-1h-піразол-3-іл]-2-[4-(1-трифторметилциклопропіл)-феніл]-ацетаміду - Google Patents
Кристалічна форма n-[1-(5-ціанопіридин-2-ілметил)-1h-піразол-3-іл]-2-[4-(1-трифторметилциклопропіл)-феніл]-ацетаміду Download PDFInfo
- Publication number
- UA126582C2 UA126582C2 UAA202000506A UAA202000506A UA126582C2 UA 126582 C2 UA126582 C2 UA 126582C2 UA A202000506 A UAA202000506 A UA A202000506A UA A202000506 A UAA202000506 A UA A202000506A UA 126582 C2 UA126582 C2 UA 126582C2
- Authority
- UA
- Ukraine
- Prior art keywords
- crystalline form
- compound
- disorders
- peaks
- pain
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2017066806 | 2017-07-05 | ||
| PCT/EP2018/068087 WO2019008034A1 (en) | 2017-07-05 | 2018-07-04 | CRYSTALLINE FORM OF N- [1- (5-CYANO-PYRIDIN-2-YLMETHYL) -1H-PYRAZOL-3-YL] -2- [4- (1-TRIFLUOROMETHYL-CYCLOPROPYL) -PHENYL] -ACETAMIDE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA126582C2 true UA126582C2 (uk) | 2022-11-02 |
Family
ID=63079885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA202000506A UA126582C2 (uk) | 2017-07-05 | 2018-07-04 | Кристалічна форма n-[1-(5-ціанопіридин-2-ілметил)-1h-піразол-3-іл]-2-[4-(1-трифторметилциклопропіл)-феніл]-ацетаміду |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US11059803B2 (https=) |
| EP (1) | EP3649117B1 (https=) |
| JP (2) | JP2020525475A (https=) |
| KR (1) | KR102645911B1 (https=) |
| CN (1) | CN110831932A (https=) |
| AU (1) | AU2018296423B2 (https=) |
| BR (1) | BR112020000099A2 (https=) |
| CA (1) | CA3067489A1 (https=) |
| CL (1) | CL2020000002A1 (https=) |
| EA (1) | EA202090193A1 (https=) |
| IL (1) | IL271764B2 (https=) |
| MA (1) | MA50972A (https=) |
| MY (1) | MY206357A (https=) |
| PH (1) | PH12020500040A1 (https=) |
| SG (1) | SG11201912881SA (https=) |
| UA (1) | UA126582C2 (https=) |
| WO (1) | WO2019008034A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110072521B (zh) | 2016-12-16 | 2022-11-29 | 爱杜西亚药品有限公司 | 包含t型钙通道阻断剂的药物组合 |
| MA47409A (fr) | 2017-02-06 | 2019-12-11 | Idorsia Pharmaceuticals Ltd | Nouveau procédé de synthèse de 1-aryl-1-trifluorométhylcyclopropanes |
| EP3649117B1 (en) * | 2017-07-05 | 2024-10-09 | Idorsia Pharmaceuticals Ltd | Crystalline form of n -[1-(5-cyano-pyridin-2-ylmethyl)-1 h -pyrazol-3-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide |
| TW202128158A (zh) | 2019-12-20 | 2021-08-01 | 瑞士商愛杜西亞製藥有限公司 | 包含n-[1-(5-氰基-吡啶-2-基甲基)-1h-吡唑-3-基]-2-[4-(1-三氟甲基-環丙基)-苯基]-乙醯胺之醫藥組合物 |
| EP4389892A4 (en) * | 2021-08-17 | 2025-12-10 | Korea Advanced Inst Sci & Tech | Antisense oligonucleotide targeting the CAV3.1 gene and its uses |
| WO2023240205A1 (en) | 2022-06-10 | 2023-12-14 | Neurocrine Biosciences, Inc. | Deuterated compounds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6195684B2 (ja) * | 2014-06-03 | 2017-09-13 | アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | ピラゾール化合物及びｔ型カルシウムチャンネルブロッカーとしてのそれらの使用 |
| WO2016041892A1 (en) | 2014-09-15 | 2016-03-24 | Actelion Pharmaceuticals Ltd | Triazole compounds as t-type calcium channel blockers |
| CN110072521B (zh) | 2016-12-16 | 2022-11-29 | 爱杜西亚药品有限公司 | 包含t型钙通道阻断剂的药物组合 |
| MA47409A (fr) | 2017-02-06 | 2019-12-11 | Idorsia Pharmaceuticals Ltd | Nouveau procédé de synthèse de 1-aryl-1-trifluorométhylcyclopropanes |
| EP3649117B1 (en) * | 2017-07-05 | 2024-10-09 | Idorsia Pharmaceuticals Ltd | Crystalline form of n -[1-(5-cyano-pyridin-2-ylmethyl)-1 h -pyrazol-3-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide |
-
2018
- 2018-07-04 EP EP18749304.4A patent/EP3649117B1/en active Active
- 2018-07-04 MA MA050972A patent/MA50972A/fr unknown
- 2018-07-04 CN CN201880044771.7A patent/CN110831932A/zh active Pending
- 2018-07-04 IL IL271764A patent/IL271764B2/en unknown
- 2018-07-04 CA CA3067489A patent/CA3067489A1/en active Pending
- 2018-07-04 SG SG11201912881SA patent/SG11201912881SA/en unknown
- 2018-07-04 US US16/628,618 patent/US11059803B2/en active Active
- 2018-07-04 AU AU2018296423A patent/AU2018296423B2/en not_active Ceased
- 2018-07-04 BR BR112020000099-0A patent/BR112020000099A2/pt active Search and Examination
- 2018-07-04 EA EA202090193A patent/EA202090193A1/ru unknown
- 2018-07-04 UA UAA202000506A patent/UA126582C2/uk unknown
- 2018-07-04 MY MYPI2020000011A patent/MY206357A/en unknown
- 2018-07-04 JP JP2019572102A patent/JP2020525475A/ja active Pending
- 2018-07-04 WO PCT/EP2018/068087 patent/WO2019008034A1/en not_active Ceased
- 2018-07-04 KR KR1020207002894A patent/KR102645911B1/ko active Active
-
2020
- 2020-01-02 CL CL2020000002A patent/CL2020000002A1/es unknown
- 2020-01-03 PH PH12020500040A patent/PH12020500040A1/en unknown
-
2021
- 2021-06-11 US US17/345,844 patent/US11555025B2/en active Active
-
2023
- 2023-06-26 JP JP2023104050A patent/JP2023123679A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20210300894A1 (en) | 2021-09-30 |
| KR20200018698A (ko) | 2020-02-19 |
| EA202090193A1 (ru) | 2020-06-03 |
| MA50972A (fr) | 2020-10-14 |
| CL2020000002A1 (es) | 2020-07-31 |
| IL271764A (en) | 2020-02-27 |
| EP3649117B1 (en) | 2024-10-09 |
| US11555025B2 (en) | 2023-01-17 |
| IL271764B1 (en) | 2023-06-01 |
| SG11201912881SA (en) | 2020-01-30 |
| JP2020525475A (ja) | 2020-08-27 |
| US11059803B2 (en) | 2021-07-13 |
| AU2018296423A1 (en) | 2020-02-20 |
| JP2023123679A (ja) | 2023-09-05 |
| BR112020000099A2 (pt) | 2020-07-07 |
| MY206357A (en) | 2024-12-12 |
| KR102645911B1 (ko) | 2024-03-08 |
| CA3067489A1 (en) | 2019-01-10 |
| US20200165221A1 (en) | 2020-05-28 |
| CN110831932A (zh) | 2020-02-21 |
| IL271764B2 (en) | 2023-10-01 |
| WO2019008034A1 (en) | 2019-01-10 |
| EP3649117A1 (en) | 2020-05-13 |
| AU2018296423B2 (en) | 2022-07-28 |
| PH12020500040A1 (en) | 2020-10-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| UA126582C2 (uk) | Кристалічна форма n-[1-(5-ціанопіридин-2-ілметил)-1h-піразол-3-іл]-2-[4-(1-трифторметилциклопропіл)-феніл]-ацетаміду | |
| CA2865585C (en) | N-(5s, 6s, 9r)-5-amino-6-(2,3-difluorophenyl)-6, 7, 8, 9-tetrahydro-5h-cyclohepta [b] pyridin-9-yl-4-(2-oxo-2, 3-dihydro-1h-imidazo [4, 5-b] pyridin-1-yl) piperidine-1-carboxylate,hemisulfate salt | |
| EP2276758B1 (en) | Crystal forms of 5- [3- (2, 5-dichloro-4, 6-dimethyl-1-oxy-pyridine-3-yl) [1,2,4] oxadiazol-5-yl]-3-nit robenzene-1, 2-diol | |
| EP3456722B1 (en) | Crystal forms of crisaborole in free form and preparation method and use thereof | |
| EP3610875A1 (en) | Opioid receptor (mor) agonist salt, fumarate salt i crystal form thereof and preparation method thereof | |
| KR20130136544A (ko) | 아고멜라틴의 신규한 결정성 형태 vii, 및 이의 제조 방법 및 용도 및 이를 함유하는 약학적 조성물 | |
| US20210002307A1 (en) | Crystal Forms of Crisaborole In Free Form And Preparation Method And Use Thereof | |
| CN111094272B (zh) | 一种otr抑制剂的可药用盐、晶型及制备方法 | |
| CN108794383B (zh) | 硝苯地平与异烟酰胺的共晶 | |
| WO2024051771A1 (zh) | 一种五元并六元杂环化合物的晶型及其制备方法和应用 | |
| CN111094273B (zh) | 催产素受体抑制剂的晶型及其制备方法 | |
| TWI711612B (zh) | 氮雜雙環基取代的三唑類衍生物的可藥用鹽、晶型及製備方法 | |
| CN108484470B (zh) | 一种奥拉西坦的制备方法 | |
| CN119306783A (zh) | 一种甾体类化合物的晶型及其用途 |