UA121268U - METHOD OF DIAGNOSTICS OF ATHEROSCLEROSIS DEVELOPMENT - Google Patents

Abstract

Diagnostic method for the development of atherosclerosis includes clinical examination, studies of low and high density lipoprotein cholesterol levels, arteriography, determination of serum nitric oxide synthase gene polymorphism (eNOS T786C), thrombodulin, folic acid and folic acid C-reactive protein (PSA), interleukin 6 (IL-6). With homozygous carrier 786-SS, thrombomodulin levels> 5 ng / ml, folic acid <6 ng / ml, CICP <102 ng / ml, SRP> 6 mg / l, IL-6> 10 ng / l diagnose the development of atherosclerosis.

Description

The proposed method of diagnosing the development of atherosclerosis belongs to medicine, in particular to therapy and rheumatology. It is prescribed and can be used in the treatment and examination of patients.

Ways of diagnosing the development of atherosclerosis are known. These include determination of low- and high-density lipoprotein cholesterol levels, arteriography (A.N. Okorokov.

Diagnosis of diseases of internal organs. -T. 6-S. 75-85).

However, the known method is not effective enough and does not allow diagnosing the development of atherosclerosis even at the onset of the disease. Accordingly, there is no possibility to prevent atherosclerosis.

The basis of a useful model is the task of developing a method that would allow diagnosing the onset of atherosclerosis at an early stage.

The task is solved by the fact that along with the study of low and high density lipoprotein cholesterol levels, arteriography in the patient's blood serum determines the polymorphism of the nitric oxide synthase gene (eMmo5 T786C), the content of thrombomodulin, folic acid,

C-terminal propeptide of type I collagen (SICP), C-reactive protein (CRP), interleukin b (IL-6). With homozygous carrier 786-SS, levels of thrombomodulin "5 ng/ml, folic acid "b ng/ml, SISR "102 ng/ml, SRP 26 mg/l, IL-b6 510 ng/l diagnose the development of atherosclerosis.

Application of the method. During hospitalization, the patient is examined, low- and high-density lipoprotein cholesterol levels are examined, and arteriography is performed. In the blood serum of the patient, the polymorphism of the eMmo5 T786C gene is determined, the content of thrombomodulin, folic acid, SISR, SRP, IL-6 is determined by the immunoenzymatic method. With homozygous carrier 786-SS, levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml, SSRI "102 ng/ml, SRP "6 mg/l, IL-b6 210 ng/l, the development of atherosclerosis is diagnosed.

A specific example of using the method.

Patient T., 46 years old, was hospitalized with a diagnosis of rheumatoid arthritis. Inspected.

Low and high density lipoprotein cholesterol levels were studied. Arteriography was performed.

There are no signs of atherosclerosis. The emo5 T786C gene polymorphism was determined in blood serum.

The immunoenzymatic method determined the content of thrombomodulin, folic acid, SISR, SRP,

From IL-6. Homozygous carrier 786-SS was established. Levels of thrombomodulin - 9.4 ng/ml, folic acid - 3.8 ng/ml, SICP - 82 ng/ml, SRP - 14 mg/l, IL-6-17 ng/l. The development of atherosclerosis was diagnosed. Arteriographic signs of the process were revealed only after 12 months.

Thus, the proposed method of diagnosis allows establishing a diagnosis at the early stages of the development of the process.

Claims (1)

USEFUL MODEL FORMULA A method of diagnosing the development of atherosclerosis, which includes a clinical examination, a study of low and high-density lipoprotein cholesterol levels, arteriography, which is distinguished by that determine the polymorphism of the nitric oxide synthase gene (EMO 1786С), the content of thrombomodulin, folic acid, C-terminal propeptide of collagen in blood serum! type (SISR), C-reactive protein (SRP), interleukin 6 (IL-6), with homozygous carrier 786-SS, levels of thrombomodulin "5 ng/ml, folic acid "b ng/ml, SISR "102 ng/ml , SRP »6b mg/l, IL-b »10 ng/l diagnose the development of atherosclerosis.