UA121231U - METHOD OF DIAGNOSTICS OF ATHEROSCLEROSIS DEVELOPMENT - Google Patents

Abstract

A method of diagnosing the development of atherosclerosis includes clinical examination, studies of low and high density lipoprotein cholesterol levels, arteriography, determination of eNOS T786C gene polymorphism in serum, thrombomodulin content, folic acid, CISR, SRP, SRP, SRP, SRP. With homozygous carrier 786-SS, thrombomodulin levels> 5 ng / ml, folic acid <6 ng / ml, SICP <102 ng / ml, SRP> 6 mg / l, IL-6> 10 ng / l, homocysteine> 20 μmol / l diagnose the development of atherosclerosis.

Description

The proposed method of diagnosing the development of atherosclerosis belongs to medicine, in particular to therapy and rheumatology. It is prescribed and can be used in the treatment and examination of patients.

Ways of diagnosing the development of atherosclerosis are known. These include determination of cholesterol levels of low and high density lipoproteins, arteriography (|Okorokov A.N. Diagnostics of diseases of internal organs. - Vol. 6. - M.: Med. lit., 2003. - P. 75-85).

However, the known method is not effective enough and does not allow diagnosing the development of atherosclerosis even at the onset of the disease. Accordingly, there is no possibility to prevent atherosclerosis.

The basis of a useful model is the task of developing a method that would allow diagnosing the onset of atherosclerosis at an early stage.

The task is solved by the fact that along with the study of low and high density lipoprotein cholesterol levels, the polymorphism of the nitric oxide synthase gene (EMO5 17860), the content of thrombomodulin, folic acid,

C-terminal propeptide of type I collagen (SICP), C-reactive protein (CRP), interleukin b (IL-6), homocysteine. With homozygous carrier 786-SS, levels of thrombomodulin "5 ng/ml, folic acid "b ng/ml, SISR "102 ng/ml, SRP "6 mg/l, IL-6 "10 ng/l, homocysteine 220 μmol/ l diagnose the development of atherosclerosis.

Application of the method. During hospitalization, the patient is examined, low- and high-density lipoprotein cholesterol levels are examined, and arteriography is performed. In the blood serum of the patient, the polymorphism of the eEMO5 1786C gene is determined, the content of thrombomodulin, folic acid, SISR, SRP, IL-6, and homocysteine is determined by the immunoenzymatic method. With homozygous carrier 786-SS, levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml, SISR "102 ng/ml, SRP "6 mg/l, IL-6 510 ng/l, homocysteine 220 μmol/l diagnose the development of atherosclerosis.

A specific example of using the method.

Patient M., 43 years old, hospitalized in the clinic with a diagnosis of rheumatoid arthritis. Examined

Low and high density lipoprotein cholesterol levels were studied. Arteriography was performed.

There are no signs of atherosclerosis. Polymorphism of the eMO5 T7860 gene was determined in blood serum.

The content of thrombomodulin, folic acid, SISR, SRP, IL-

From 6, homocysteine. Homozygous carrier 786-SS was established. Levels of thrombomodulin - 10 ng/ml, folic acid - 2.9 ng/ml, SICP - 69 ng/ml, SRP - 11 mg/l, IL-6-19 ng/l, homocysteine - 25 μmol/l. The development of atherosclerosis was diagnosed. Arteriographic signs of the process were revealed only after 12 months.

Thus, the proposed method of diagnosis allows establishing a diagnosis at the early stages of the development of the process.

Claims (1)

USEFUL MODEL FORMULA The method of diagnosing the development of atherosclerosis, which includes a clinical examination, level research 40 low- and high-density lipoprotein cholesterol, arteriography, serum determination of eMO5 1786C gene polymorphism, thrombomodulin content, folic acid, SISR, SRP, IL-b, homocysteine, which differs in that with homozygous carrier 786-SS, thrombomodulin levels » 5 ng/ml, folic acid "6 ng/ml, SISR "102 ng/ml, SRP "b6 mg/l, IL-b6 510 ng/l, homocysteine 220 μmol/l diagnose the development of atherosclerosis.