UA122154U - METHOD OF DIAGNOSTICS OF ATHEROSCLEROSIS DEVELOPMENT - Google Patents

Abstract

A method of diagnosing the development of atherosclerosis, including clinical examination, examination of low and high density lipoprotein cholesterol levels, arteriography. Additionally, serum eNOS T786C polymorphism, thrombomodulin content, folic acid, PSA, IL-6, TGF- (1 and homozygous carrier 786-SS, thrombomodulin levels> 5 ng / ml, folic acid 6 ml / ml, 6 fol / ml, are further determined. , CRP> 6 mg / l, IL-6> 10 ng / l, TGF- (1 <14 ng / ml diagnose the development of atherosclerosis.

Description

The proposed useful model - the method of diagnosing the development of atherosclerosis belongs to medicine, in particular to therapy and rheumatology. It is prescribed and can be used in the treatment and examination of patients.

Ways of diagnosing the development of atherosclerosis are known. These include determination of cholesterol levels of low and high density lipoproteins, arteriography (A.N. Okorokov. Diagnostics of diseases of internal organs. -Vol. 6-S. 75-85).

However, the known method is not effective enough and does not allow diagnosing the development of atherosclerosis even at the onset of the disease. Accordingly, there is no possibility of prevention of atherosclerosis.

The basis of a useful model is the task of developing a method that will allow diagnosing the occurrence of atherosclerosis at an early stage.

The task is solved by the fact that along with the study of low and high density lipoprotein cholesterol levels, arteriography in the patient's blood serum determines the polymorphism of the nitric oxide synthase gene (eMmo5 T786C), the content of thrombomodulin, folic acid,

C-reactive protein (CRP), interleukin 6 (IL-6), transforming growth factor beta 1 (TGF-B1). At homozygous carrier 786-SS, levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml, SRP "2b mg/l, IL-b "10 ng/l, TGF-B1 "14 ng/ml diagnose the development of atherosclerosis .

Application of the method. During hospitalization, the patient is examined, low- and high-density lipoprotein cholesterol levels are examined, and arteriography is performed. In the blood serum of the patient, the polymorphism of the eMmo5 T786C gene is determined, and the content of thrombomodulin, folic acid, SRP, IL-6, and TFR-B1I is determined by the immunoenzymatic method. With homozygous carrier 786-SS, levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml, SRP "b mg/l, IL-6 "10 ng/l, TGF-DI1" 14 ng/ml, the development of atherosclerosis is diagnosed .

A specific example of using the method.

Patient B., 46 years old, was hospitalized with a diagnosis of rheumatoid arthritis. Inspected.

Low and high density lipoprotein cholesterol levels were studied. Arteriography was performed.

There are no signs of atherosclerosis. The emo5 T786C gene polymorphism was determined in blood serum.

The content of thrombomodulin, folic acid, SRP, IL-6, TGF-

From RI. Homozygous carrier 786-SS was established. Levels of thrombomodulin - 9.6 ng/ml, folic acid - 2.8 ng/ml, SRP - 10.4 mg/l, IL-6-16 ng/l, TGF-D1-8.1 ng/ml. The development of atherosclerosis was diagnosed. Arteriographic signs of the process were detected only after 13 months.

Thus, the proposed method of diagnosis allows establishing a diagnosis at the early stages of the development of the process.

Claims (1)

USEFUL MODEL FORMULA A method of diagnosing the development of atherosclerosis, which includes a clinical examination, a study of low and high-density lipoprotein cholesterol levels, arteriography, which is distinguished by which additionally determine in the blood serum the polymorphism of the eMO5 gene 1T786C, the content of thrombomodulin, folic acid, SRP, IL-6, TFR-RI and, in the case of homozygous carrier 786-SS, the levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml , SRP "b6 mg/l, IL-6 210 ng/l, TFR-DI1 "14 ng/ml diagnose the development of atherosclerosis.