UA122680U - METHOD OF DIAGNOSTICS OF ATHEROSCLEROSIS DEVELOPMENT - Google Patents

Abstract

A method of diagnosing the development of atherosclerosis includes clinical examination, examination of low and high density lipoprotein cholesterol levels, arteriography. Serum polymorphism of eNOS T786C gene, thrombomodulin content, folic acid, homocysteine, PSA, TGF- (1, with homozygous 786-SS carrier, thrombomodulin levels> 5 ng / ml, folic acid <6 g / ml, folic acid ml <6, is determined in serum μmol / l, SRP> 6 mg / l, TGF- (1 <14 ng / ml diagnose the development of atherosclerosis.

Description

The useful model belongs to medicine, in particular to therapy and rheumatology and can be used in the treatment and examination of patients.

Ways of diagnosing the development of atherosclerosis are known. These include determination of low- and high-density lipoprotein cholesterol levels, arteriography (AN Okorokov.

Diagnosis of diseases of internal organs. -T. 6-S. 75-85).

However, the known method is not effective enough and does not allow diagnosing the development of atherosclerosis even at the onset of the disease. Accordingly, there is no possibility to prevent atherosclerosis.

The basis of a useful model is the task of developing a method that would allow diagnosing the onset of atherosclerosis at an early stage.

The task is solved by the fact that along with the study of low and high-density lipoprotein cholesterol levels, arteriography in the patient's blood serum determines the polymorphism of the nitric oxide synthase gene (eMmo5 T786C), the content of thrombomodulin, folic acid, homocysteine, C-reactive protein (CRP), transforming growth factor beta 1 (TGF-VDI1).

With homozygous carrier 786-SS, levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml, homocysteine 220 μmol/l, SRP "b mg/l, TFR-B1T" 14 ng/ml, the development of atherosclerosis is diagnosed.

Application of the method. During hospitalization, the patient is examined, low- and high-density lipoprotein cholesterol levels are examined, and arteriography is performed. In the blood serum of the patient, the polymorphism of the emo gene T786C is determined, the content of thrombomodulin, folic acid, homocysteine, SRP, TGF-VI1 is determined by the immunoenzymatic method. With homozygous carrier 786-SS, levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml, homocysteine 220 μmol/l, SRP "b6 mg/l,

TFR-B1-14 ng/ml diagnose the development of atherosclerosis.

A specific example of using the method.

Patient Ts., 46 years old, was hospitalized with a diagnosis of rheumatoid arthritis. Inspected.

Low and high density lipoprotein cholesterol levels were studied. Arteriography was performed. There are no signs of atherosclerosis. The eMmo5 T786C gene polymorphism was determined in blood serum. The content of thrombomodulin, folic acid, homocysteine, SRP, TGF-DVI1 was determined by immunoenzymatic method. Homozygous carrier 786-SS was established. Levels of thrombomodulin - 12 ng/ml, folic acid - 3.1 ng/ml, homocysteine - 32 μmol/l, SRP - 19 mg/l, TGF-B1 - 8 ng/ml. The development of atherosclerosis was diagnosed. Arteriographic signs of the process were detected only after 13 months.

Thus, the proposed method of diagnosis allows establishing a diagnosis at the early stages of the development of the process.

Claims (1)

USEFUL MODEL FORMULA A method of diagnosing the development of atherosclerosis, which includes a clinical examination, a study of low and high-density lipoprotein cholesterol levels, arteriography, which is distinguished by that the blood serum determines the polymorphism of the eMMO5 gene T786C, the content of thrombomodulin, folic acid, homocysteine, SRP, TFR-DI, with homozygous carrier 786-SS, the levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml, homocysteine 220 μmol /l, SRP "b6 mg/l, TFR-DI1 "14 ng/ml diagnose the development of atherosclerosis.