UA122045U - METHOD OF DIAGNOSTICS OF ATHEROSCLEROSIS DEVELOPMENT - Google Patents

Abstract

A method of diagnosing the development of atherosclerosis includes clinical examination, examination of low and high density lipoprotein cholesterol levels, arteriography. Serum polymorphism of eNOS T786C gene, thrombomodulin content, folic acid, pyridinoline, IL-6, homocysteine, with 786-SS homozygous carrier, thrombomodulin levels> 5 ng / ml, folic acid <6 ng / ml, folic acid <6 / ml, IL-6> 10 ng / l, homocysteine> 20 μmol / l diagnose the development of atherosclerosis.

Description

The useful model belongs to medicine, in particular to therapy and rheumatology and can be used in the treatment and examination of patients.

Ways of diagnosing the development of atherosclerosis are known. These include determination of low- and high-density lipoprotein cholesterol levels, arteriography (AN Okorokov.

Diagnosis of diseases of internal organs. - Vol. 6 - pp. 75-85).

However, the known method is not effective enough and does not allow diagnosing the development of atherosclerosis even at the onset of the disease. Accordingly, there is no possibility to prevent atherosclerosis.

The basis of a useful model is the task of developing a method that would allow diagnosing the onset of atherosclerosis at an early stage.

The task is solved by the fact that along with the study of low and high density lipoprotein cholesterol levels, the polymorphism of the nitric oxide synthase gene (MOZ T786C), the content of thrombomodulin, folic acid, pyridinoline, interleukin 6 (IL-6), homocysteine is determined in the patient's blood serum by arteriography . At a homozygous carrier of 786-SS, levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml, pyridinoline "8 ng/ml, IL-6 "10 ng/l, homocysteine 220 μmol/l, the development of atherosclerosis is diagnosed.

Application of the method. During hospitalization, the patient is examined, low- and high-density lipoprotein cholesterol levels are examined, and arteriography is performed. In the blood serum of the patient, the polymorphism of the eMmo5 T786C gene is determined, the content of thrombomodulin, folic acid, pyridinoline, IL-b, and homocysteine is determined by the immunoenzymatic method. With homozygous carrier 786-SS, levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml, pyridinoline "8 ng/ml, IL-6 "10 ng/l, homocysteine g220 μmol/l, the development of atherosclerosis is diagnosed.

A specific example of using the method.

Patient P., 48 years old, was hospitalized with a diagnosis of rheumatoid arthritis. Inspected.

Low and high density lipoprotein cholesterol levels were studied. Arteriography was performed. There are no signs of atherosclerosis. The polymorphism of the eMmOo5 T786C gene was determined in the blood serum. The content of thrombomodulin, folic acid, pyridinoline, IL-6, and homocysteine was determined by immunoenzymatic method. Homozygous carrier 786-SS was established. Levels of thrombomodulin - 12.2 ng/ml, folic acid - 3.8 ng/ml, pyridinoline -16 ng/ml, IL-6-20 ng/l,

From homocysteine - 28 μmol/l. The development of atherosclerosis was diagnosed. Arteriographic signs of the process were detected only after 13 months.

Thus, the proposed method of diagnosis allows establishing a diagnosis at the early stages of the development of the process.

Claims (1)

USEFUL MODEL FORMULA A method of diagnosing the development of atherosclerosis, which includes a clinical examination, a study of low and high-density lipoprotein cholesterol levels, arteriography, which is distinguished by the fact that the eMmo5 T786C gene polymorphism, thrombomodulin content, folic acid, pyridinoline, IL-b, homocysteine, with homozygous carrier 786-SS, levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml, pyridinoline "8 ng/ml, IL-6 "10 ng/l, homocysteine 220 μmol/l diagnoses the development of atherosclerosis.