UA121236U - METHOD OF DIAGNOSTICS OF ATHEROSCLEROSIS DEVELOPMENT - Google Patents

Abstract

A method of diagnosing the development of atherosclerosis includes clinical examination, studies of low and high density lipoprotein cholesterol levels, arteriography, determination of eNOS T786C gene polymorphism in serum, thrombomodulin content, folic acid, CISR, IL-6. With homozygous carrier 786-SS, thrombomodulin levels> 5 ng / ml, folic acid <6 ng / ml, CICP <102 ng / ml, IL-6> 10 ng / l, homocysteine> 20 μmol / l diagnose the development of atherosclerosis.

Description

The proposed method of diagnosing the development of atherosclerosis belongs to medicine, in particular to therapy and rheumatology. It is prescribed and can be used in the treatment and examination of patients.

Ways of diagnosing the development of atherosclerosis are known. These include determination of low- and high-density lipoprotein cholesterol levels, arteriography (Okorokov A.N.

Diagnosis of diseases of internal organs. - T. 6. - M.: Med. lit., 2003. - pp. 75-85).

However, the known method is not effective enough and does not allow diagnosing the development of atherosclerosis even at the onset of the disease. Accordingly, there is no possibility to prevent atherosclerosis.

The basis of a useful model is the task of developing a method that would allow diagnosing the onset of atherosclerosis at an early stage.

The task is solved by the fact that along with the study of low and high density lipoprotein cholesterol levels, arteriography in the patient's blood serum determines the polymorphism of the nitric oxide synthase gene (eMmo5 T786C), the content of thrombomodulin, folic acid,

C-terminal propeptide of collagen | type (SISR), interleukin b (IL-6), homocysteine. With homozygous carrier 786-SS, levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml,

SISR "102 ng/ml, IL-6 510 ng/l, homocysteine 220 μmol/l diagnose the development of atherosclerosis.

Application of the method. During hospitalization, the patient is examined, low- and high-density lipoprotein cholesterol levels are examined, and arteriography is performed. In the blood serum of the patient, the polymorphism of the eMmo5 T786C gene is determined, the content of thrombomodulin, folic acid, SISR, IL-b6, and homocysteine is determined by the immunoenzymatic method. At homozygous carrier 786-SS, levels of thrombomodulin "5 ng/ml, folic acid "b ng/ml, SISR "102 ng/ml, IL-b "10 ng/l., homocysteine 220 μmol/l diagnose the development of atherosclerosis.

A specific example of using the method

Patient M., 38 years old, was hospitalized with a diagnosis of rheumatoid arthritis. Inspected.

Low and high density lipoprotein cholesterol levels were studied. Arteriography was performed.

There are no signs of atherosclerosis. The emo gene polymorphism 7T786C was determined in blood serum.

The immunoenzymatic method determined the content of thrombomodulin, folic acid, SISR, IL-b,

From homocysteine. Homozygous carrier 786-SS was established. Levels of thrombomodulin - 10 ng/ml, folic acid - 2.9 ng/ml, SICP - 70 ng/ml, IL-6-19 ng/l, homocysteine - 30 μmol/l.

The development of atherosclerosis was diagnosed. Arteriographic signs of the process were revealed only after 12 months.

Thus, the proposed method of diagnosis allows establishing a diagnosis at the early stages of the development of the process.

Claims (1)

USEFUL MODEL FORMULA The method of diagnosing the development of atherosclerosis, which includes a clinical examination, level research 40 low- and high-density lipoprotein cholesterol, arteriography, determination of the eMOo5 1786C gene polymorphism in blood serum, the content of thrombomodulin, folic acid, SSRI, IL-b, homocysteine, which is distinguished by the fact that with homozygous carrier 786-SS, thrombomodulin levels »5 ng /ml, folic acid "6 ng/ml, SISR "102 ng/ml, IL-b "10 ng/l, homocysteine 20 μmol/l diagnose the development of atherosclerosis.