UA121244U - METHOD OF DIAGNOSTICS OF ATHEROSCLEROSIS DEVELOPMENT - Google Patents

Abstract

A method of diagnosing the development of atherosclerosis includes clinical examination, studies of low and high density lipoprotein cholesterol levels, arteriography, determination of MTHFR C677T, eNOS T786C gene polymorphism, thrombomodulin content, folic acid, folic acid, thrombomodulin, folic acid content in serum. In the homozygous carrier 677-TT, 786-CC, thrombomodulin levels> 5 ng / ml, folic acid <6 ng / ml, oxyproline> 15 μmol / l, PSA> 6 mg / l, IL-6> 10 ng / l are diagnosed development of atherosclerosis.

Description

The proposed method of diagnosing the development of atherosclerosis belongs to medicine, in particular to therapy and rheumatology. It is prescribed and can be used in the treatment and examination of patients.

Ways of diagnosing the development of atherosclerosis are known. These include determination of low- and high-density lipoprotein cholesterol levels, arteriography (Okorokov A.N.

Diagnosis of diseases of internal organs. - T. 6. - M.: Med. lit., 2003. - pp. 75-85).

However, the known method is not effective enough and does not allow diagnosing the development of atherosclerosis even at the onset of the disease. Accordingly, there is no possibility to prevent atherosclerosis.

The basis of a useful model is the task of developing a method that would allow diagnosing the onset of atherosclerosis at an early stage.

The task is solved by the fact that along with the study of low and high-density lipoprotein cholesterol levels, arteriography in the patient's blood serum determines the polymorphism of the methylenetetrahydrofolate reductase (MITNEK S677Т), nitric oxide synthase (EMOS T786С), content of thrombomodulin, folic acid, oxyproline, C-reactive protein (SRP), interleukin b (IL-6). With homozygous carrier 677-117, 786-SS, levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml, oxyproline 215 μmol/l, SRP "b mg/l,

IL-6 210 ng/l diagnoses the development of atherosclerosis.

Application of the method. During hospitalization, the patient is examined, low- and high-density lipoprotein cholesterol levels are examined, and arteriography is performed. Polymorphism of MTNEK C677T, emo T786C genes, thrombomodulin, folic acid, oxyproline, SRP, IL-6 content are determined in serum. With homozygous carrier 677-1T, 786-SS, levels of thrombomodulin 25 ng/ml, folic acid "6 ng/ml, oxyproline 215 μmol/l,

SRP »6 mg/l, IL-6 »10 ng/l diagnose the development of atherosclerosis.

A specific example of using the method

Patient P., 42 years old, was hospitalized with a diagnosis of rheumatoid arthritis. Inspected.

Low and high density lipoprotein cholesterol levels were studied. An arteriography of vessels was performed. There are no signs of atherosclerosis. Polymorphism of MTNEK genes was determined in blood serum

C677T and emoz T786S. The content of thrombomodulin, folic acid, oxyproline, SRP, IL-6 was determined by immunoenzymatic method. Homozygous carrier of 677-GTT and 786-SS was established. Levels of thrombomodulin - 14 ng/ml, folic acid - 3.8 ng/ml, oxyproline - 30 μmol/l, SRP - 16 mg/l, IL-6-19 ng/l. The development of atherosclerosis was diagnosed. Arteriographic signs of the latter were detected only after 12 months.

Thus, the proposed method allows diagnosing atherosclerosis in the early stages.

Claims (1)

USEFUL MODEL FORMULA The method of diagnosing the development of atherosclerosis, which includes a clinical examination, level research 40 low- and high-density lipoprotein cholesterol, arteriography, determination of MTNEV C677T, eMmO5 T786C gene polymorphisms in blood serum, the content of thrombomodulin, folic acid, oxyproline, SRP, IL-6, which is distinguished by the fact that with homozygous carriers 67 7- TT, 786 -SS, levels of thrombomodulin "5 ng/ml, folic acid "b ng/ml, oxyproline 215 μmol/l, SRP 26 mg/l, IL-6 210 ng/l diagnose the development of atherosclerosis.