UA121238U - METHOD OF DIAGNOSTICS OF ATHEROSCLEROSIS DEVELOPMENT - Google Patents

Abstract

A method of diagnosing the development of atherosclerosis includes clinical examination, studies of low and high density lipoprotein cholesterol levels, arteriography, determination of serum polymorphism of MTHFR C677T, eNOS T786C, thrombomodulin, folic acid, thrombomodulin, folic acid, polymorphism. When homozygous carrier 677-TT, 786-CC, thrombomodulin levels> 5 ng / ml, folic acid <6 ng / ml, oxyproline> 15 μmol / l, PSA> 6 mg / l, homocysteine> 20 μmol / l diagnose the development of atherosclerosis .

Description

The proposed method of diagnosing the development of atherosclerosis belongs to medicine, in particular to therapy and rheumatology. It is prescribed and can be used in the treatment and examination of patients.

Ways of diagnosing the development of atherosclerosis are known. These include determination of low- and high-density lipoprotein cholesterol levels, arteriography (Okorokov A.N.

Diagnosis of diseases of internal organs. - T. 6. - M.: Med. lit., 2003. - pp. 75-85).

However, the known method is not effective enough and does not allow diagnosing the development of atherosclerosis even at the onset of the disease. Accordingly, there is no possibility to prevent atherosclerosis.

The basis of a useful model is the task of developing a method that would allow diagnosing the onset of atherosclerosis at an early stage.

The task is solved by the fact that along with the study of low and high-density lipoprotein cholesterol levels, arteriography in the patient's blood serum determines the polymorphism of the methylenetetrahydrofolate reductase (MITNEK S677Т), nitric oxide synthase (EMOS T786С), content of thrombomodulin, folic acid, oxyproline, C-reactive protein (SRP), homocysteine. With homozygous carriers of 677-TT, 786-SS, levels of thrombomodulin 25 ng/ml, folic acid "6 ng/ml, oxyproline 215 μmol/l, SRP "6 mg/l, homocysteine 220 μmol/l, the development of atherosclerosis is diagnosed.

Application of the method. During hospitalization, the patient is examined, low- and high-density lipoprotein cholesterol levels are examined, and arteriography is performed. Polymorphism of MTNEK C677T, emMmo5 T7786C genes, thrombomodulin, folic acid, oxyproline, SRP, homocysteine content are determined in serum. With homozygous carrier 677-HT, 786-SS, levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml, oxyproline 215 μmol/l, SRP "b mg/l, homocysteine 220 μmol/l, the development of atherosclerosis is diagnosed.

A specific example of using the method

Patient L., 44 years old, was hospitalized with a diagnosis of rheumatoid arthritis. Inspected.

Low and high density lipoprotein cholesterol levels were studied. An arteriography of vessels was performed. There are no signs of atherosclerosis. Polymorphism of MTNEK genes was determined in blood serum

From S677tT and eMmoz T786S. The content of thrombomodulin, folic acid, oxyproline, SRP, homocysteine was determined by immunoenzymatic method. Homozygous carriers of 677-111 and 786-SS were established.

Levels of thrombomodulin - 11.2 ng/ml, folic acid - 4.2 ng/ml, oxyproline - 28 μmol/l, SRP - 18 mg/l, homocysteine - 26 μmol/l. The development of atherosclerosis was diagnosed. Arteriographic signs of the latter were detected only after 12 months.

Thus, the proposed method allows diagnosing atherosclerosis in the early stages.

Claims (1)

USEFUL MODEL FORMULA 40 The method of diagnosing the development of atherosclerosis, which includes a clinical examination, examination of low and high-density lipoprotein cholesterol levels, arteriography, determination of polymorphism of MTNEV C677T, eMmO5 T786C genes in blood serum, the content of thrombomodulin, folic acid, oxyproline, SRP, homocysteine, which differs in that that with homozygous carrier 677-HT, 786-SS, levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml, 45 oxyproline 215 μmol/l, SRP »b mg/l, homocysteine 220 μmol/l diagnose the development of atherosclerosis.