UA112420C2 - Інгібітори апоптозу та їх застосування - Google Patents
Інгібітори апоптозу та їх застосуванняInfo
- Publication number
- UA112420C2 UA112420C2 UAA201306150A UAA201306150A UA112420C2 UA 112420 C2 UA112420 C2 UA 112420C2 UA A201306150 A UAA201306150 A UA A201306150A UA A201306150 A UAA201306150 A UA A201306150A UA 112420 C2 UA112420 C2 UA 112420C2
- Authority
- UA
- Ukraine
- Prior art keywords
- fragments
- applications
- apoptosis inhibitors
- derivatives
- apoptosis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4747—Apoptosis related proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Marine Sciences & Fisheries (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Винахід стосується фрагментів DAXX протеїнів, які інгібують клітинний апоптоз, зокрема клітинний апоптоз, опосередкований Fas рецептором. Винахід, крім того, стосується похідних зазначених антиапоптозних фрагментів, кон'югатів, які містять зазначені фрагменти, фармацевтичних композицій, які містять зазначені фрагменти, та медичних застосувань зазначених фрагментів, похідних, кон'югатів та їх фармацевтичних композицій в лікуванні або попередженні захворювань або станів, пов'язаних з апоптозом.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IB2010/003158 WO2012066376A1 (en) | 2010-11-18 | 2010-11-18 | Inhibitors of apoptosis and uses thereof |
PCT/EP2011/070404 WO2012066103A2 (en) | 2010-11-18 | 2011-11-17 | Inhibitors of apoptosis and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
UA112420C2 true UA112420C2 (uk) | 2016-09-12 |
Family
ID=43880951
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201306150A UA112420C2 (uk) | 2010-11-18 | 2011-11-17 | Інгібітори апоптозу та їх застосування |
Country Status (36)
Country | Link |
---|---|
US (1) | US9814758B2 (uk) |
EP (2) | EP2982685B1 (uk) |
JP (1) | JP6204828B2 (uk) |
KR (2) | KR102017645B1 (uk) |
CN (2) | CN103403023B (uk) |
AU (1) | AU2011331103B2 (uk) |
BR (1) | BR112013012362A2 (uk) |
CA (2) | CA3078178C (uk) |
CL (1) | CL2013001411A1 (uk) |
CO (1) | CO6700879A2 (uk) |
CR (1) | CR20130190A (uk) |
CY (1) | CY1118022T1 (uk) |
DK (1) | DK2640739T3 (uk) |
EA (1) | EA027336B1 (uk) |
ES (2) | ES2553770T3 (uk) |
GE (1) | GEP201606514B (uk) |
GT (1) | GT201300117A (uk) |
HK (1) | HK1184791A1 (uk) |
HR (1) | HRP20151165T1 (uk) |
HU (1) | HUE026150T2 (uk) |
IL (2) | IL226005B (uk) |
MA (1) | MA34670B1 (uk) |
ME (1) | ME02291B (uk) |
MX (1) | MX345594B (uk) |
MY (1) | MY170604A (uk) |
NI (1) | NI201300045A (uk) |
NZ (1) | NZ610620A (uk) |
PL (1) | PL2640739T3 (uk) |
PT (1) | PT2640739E (uk) |
RS (1) | RS54422B1 (uk) |
RU (1) | RU2582247C2 (uk) |
SG (1) | SG190681A1 (uk) |
SI (1) | SI2640739T1 (uk) |
UA (1) | UA112420C2 (uk) |
WO (2) | WO2012066376A1 (uk) |
ZA (1) | ZA201303042B (uk) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10632237B2 (en) | 2006-10-09 | 2020-04-28 | Minnetronix, Inc. | Tangential flow filter system for the filtration of materials from biologic fluids |
WO2012066376A1 (en) * | 2010-11-18 | 2012-05-24 | Centre National De La Recherche Scientifique - Cnrs - | Inhibitors of apoptosis and uses thereof |
GB201314610D0 (en) * | 2013-08-15 | 2013-10-02 | Blueberry Therapeutics Ltd | Compounds and their uses |
CN103585618B (zh) * | 2013-10-31 | 2016-04-06 | 中山大学 | 端粒结合蛋白daxx在制备肿瘤细胞调控剂中的应用 |
WO2017082707A1 (ko) * | 2015-11-13 | 2017-05-18 | 한양대학교 산학협력단 | 비강 투여를 통한 뇌졸중 치료용 조성물 |
WO2019195693A1 (en) * | 2018-04-05 | 2019-10-10 | University Of Florida Research Foundation | Polypeptide inhibitor of de novo lipogenesis in cancer cells |
CN108753820A (zh) * | 2018-06-07 | 2018-11-06 | 嘉兴学院 | Daxx蛋白通过激活erk信号通路促进卵巢癌腹水细胞增殖和转移 |
CN112679595B (zh) * | 2020-04-10 | 2022-11-01 | 南京市儿童医院 | 脑源肽或融合肽在新生儿缺氧缺血性脑损伤药物中的应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6159731A (en) * | 1997-02-12 | 2000-12-12 | Massachusetts Institute Of Technology | Daxx, a Fas-binding protein that activates JNK and apoptosis |
MXPA03007358A (es) * | 2001-02-16 | 2004-12-13 | Cellgate Inc | Transportadores que contienen porciones de arginina separadas. |
RU2328273C2 (ru) * | 2001-12-19 | 2008-07-10 | Рисерч Дивелопмент Фаундейшн | Липосомальная доставка соединений, основанных на витамине е |
KR100597615B1 (ko) * | 2004-05-07 | 2006-07-10 | 주식회사 동부한농 | 인간 NHE1 이온채널 단백질 결합제로서의 인간Daxx 단백질 및 그의 단편 |
WO2010006177A2 (en) * | 2008-07-10 | 2010-01-14 | Dana-Farber Cancer Institute, Inc. | Muc1, caspase-8,and ded-containing proteins |
WO2012066376A1 (en) * | 2010-11-18 | 2012-05-24 | Centre National De La Recherche Scientifique - Cnrs - | Inhibitors of apoptosis and uses thereof |
-
2010
- 2010-11-18 WO PCT/IB2010/003158 patent/WO2012066376A1/en active Application Filing
-
2011
- 2011-11-17 AU AU2011331103A patent/AU2011331103B2/en not_active Ceased
- 2011-11-17 HU HUE11785011A patent/HUE026150T2/en unknown
- 2011-11-17 CA CA3078178A patent/CA3078178C/en active Active
- 2011-11-17 ES ES11785011.5T patent/ES2553770T3/es active Active
- 2011-11-17 KR KR1020187030658A patent/KR102017645B1/ko active IP Right Grant
- 2011-11-17 UA UAA201306150A patent/UA112420C2/uk unknown
- 2011-11-17 CA CA2816827A patent/CA2816827C/en active Active
- 2011-11-17 GE GEAP201113091A patent/GEP201606514B/en unknown
- 2011-11-17 EA EA201300592A patent/EA027336B1/ru not_active IP Right Cessation
- 2011-11-17 ME MEP-2015-184A patent/ME02291B/me unknown
- 2011-11-17 PT PT117850115T patent/PT2640739E/pt unknown
- 2011-11-17 KR KR1020137015652A patent/KR101913285B1/ko active IP Right Grant
- 2011-11-17 US US13/885,956 patent/US9814758B2/en active Active
- 2011-11-17 ES ES15182520.5T patent/ES2653734T3/es active Active
- 2011-11-17 RS RS20150753A patent/RS54422B1/en unknown
- 2011-11-17 BR BR112013012362A patent/BR112013012362A2/pt not_active Application Discontinuation
- 2011-11-17 CN CN201180055357.4A patent/CN103403023B/zh active Active
- 2011-11-17 EP EP15182520.5A patent/EP2982685B1/en active Active
- 2011-11-17 DK DK11785011.5T patent/DK2640739T3/en active
- 2011-11-17 NZ NZ610620A patent/NZ610620A/en not_active IP Right Cessation
- 2011-11-17 MY MYPI2013001678A patent/MY170604A/en unknown
- 2011-11-17 WO PCT/EP2011/070404 patent/WO2012066103A2/en active Application Filing
- 2011-11-17 CN CN201610579046.2A patent/CN106188271B/zh active Active
- 2011-11-17 EP EP11785011.5A patent/EP2640739B1/en active Active
- 2011-11-17 JP JP2013539274A patent/JP6204828B2/ja active Active
- 2011-11-17 PL PL11785011T patent/PL2640739T3/pl unknown
- 2011-11-17 SG SG2013034939A patent/SG190681A1/en unknown
- 2011-11-17 SI SI201130663T patent/SI2640739T1/sl unknown
- 2011-11-17 RU RU2013127565/10A patent/RU2582247C2/ru not_active IP Right Cessation
- 2011-11-17 MX MX2013005587A patent/MX345594B/es active IP Right Grant
-
2013
- 2013-04-25 ZA ZA2013/03042A patent/ZA201303042B/en unknown
- 2013-04-28 IL IL226005A patent/IL226005B/en active IP Right Grant
- 2013-05-02 CR CR20130190A patent/CR20130190A/es unknown
- 2013-05-08 GT GT201300117A patent/GT201300117A/es unknown
- 2013-05-14 NI NI201300045A patent/NI201300045A/es unknown
- 2013-05-15 MA MA35909A patent/MA34670B1/fr unknown
- 2013-05-16 CO CO13121197A patent/CO6700879A2/es unknown
- 2013-05-17 CL CL2013001411A patent/CL2013001411A1/es unknown
- 2013-10-25 HK HK13112062.3A patent/HK1184791A1/zh not_active IP Right Cessation
-
2015
- 2015-11-02 HR HRP20151165TT patent/HRP20151165T1/hr unknown
- 2015-11-17 CY CY20151101030T patent/CY1118022T1/el unknown
-
2018
- 2018-01-22 IL IL257069A patent/IL257069B/en active IP Right Grant
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