UA110776C2 - Мікросфера гідролізованого крохмалю з ендогенним зарядженим лігандом - Google Patents

Мікросфера гідролізованого крохмалю з ендогенним зарядженим лігандом

Info

Publication number
UA110776C2
UA110776C2 UAA201205891A UAA201205891A UA110776C2 UA 110776 C2 UA110776 C2 UA 110776C2 UA A201205891 A UAA201205891 A UA A201205891A UA A201205891 A UAA201205891 A UA A201205891A UA 110776 C2 UA110776 C2 UA 110776C2
Authority
UA
Ukraine
Prior art keywords
hydrolyzed starch
endogenous ligand
starch microspheres
nitrocarbon
ligand charged
Prior art date
Application number
UAA201205891A
Other languages
English (en)
Inventor
Малін Мальмсйо
Едді Тордарсон
Стен Пітер Арелл
Пітер Фюр
Original Assignee
Маґле Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Маґле Аб filed Critical Маґле Аб
Publication of UA110776C2 publication Critical patent/UA110776C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B31/00—Preparation of derivatives of starch
    • C08B31/003—Crosslinking of starch
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/718—Starch or degraded starch, e.g. amylose, amylopectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B31/00—Preparation of derivatives of starch
    • C08B31/02—Esters
    • C08B31/04—Esters of organic acids, e.g. alkenyl-succinated starch
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/36—Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Surgery (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Винахід стосується біологічно розкладальної мікросфери з діаметром 10-2000 мкм, яка містить перехресно-зв'язаний гідролізований крохмаль, на котрому принаймні один тип ліганду з молекулярною масою меншою 1000 Да, який є амінокислотою, органічною кислотою, що містить нітроген, дикарбоновою кислотою, сполучено через зв'язок естеру карбонової кислоти, у середньому 0,05-1,5 лігандів сполучено з кожним залишком глюкози в гідролізованому крохмалі.
UAA201205891A 2009-12-04 2010-11-17 Мікросфера гідролізованого крохмалю з ендогенним зарядженим лігандом UA110776C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0901521 2009-12-04
PCT/SE2010/051268 WO2011068455A1 (en) 2009-12-04 2010-11-17 Microspheres of hydrolysed starch with endogenous, charged ligands

Publications (1)

Publication Number Publication Date
UA110776C2 true UA110776C2 (uk) 2016-02-25

Family

ID=44115153

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201205891A UA110776C2 (uk) 2009-12-04 2010-11-17 Мікросфера гідролізованого крохмалю з ендогенним зарядженим лігандом

Country Status (21)

Country Link
US (2) US9708416B2 (uk)
EP (1) EP2506859B1 (uk)
JP (1) JP5767239B2 (uk)
KR (1) KR20120130166A (uk)
CN (1) CN102740862B (uk)
AU (1) AU2010327380B2 (uk)
BR (1) BR112012012997B8 (uk)
CA (1) CA2781593C (uk)
ES (1) ES2584319T3 (uk)
HK (1) HK1172268A1 (uk)
HR (1) HRP20160835T1 (uk)
HU (1) HUE030071T2 (uk)
IL (1) IL220069A (uk)
LT (1) LT2506859T (uk)
PL (1) PL2506859T3 (uk)
PT (1) PT2506859T (uk)
RU (2) RU2725890C2 (uk)
SI (1) SI2506859T1 (uk)
UA (1) UA110776C2 (uk)
WO (1) WO2011068455A1 (uk)
ZA (1) ZA201203497B (uk)

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KR101745748B1 (ko) 2009-10-26 2017-06-12 마이크로벤션, 인코포레이티드 팽창성 중합체로부터 제작된 색전술 장치
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Also Published As

Publication number Publication date
ZA201203497B (en) 2013-08-28
CA2781593C (en) 2018-01-23
BR112012012997A2 (pt) 2017-03-01
RU2016122487A3 (uk) 2019-11-29
ES2584319T3 (es) 2016-09-27
HK1172268A1 (en) 2013-04-19
EP2506859A1 (en) 2012-10-10
JP2013512895A (ja) 2013-04-18
BR112012012997B1 (pt) 2020-12-01
CN102740862A (zh) 2012-10-17
CN102740862B (zh) 2014-12-24
WO2011068455A1 (en) 2011-06-09
US9708416B2 (en) 2017-07-18
RU2016122487A (ru) 2018-11-29
IL220069A (en) 2017-02-28
JP5767239B2 (ja) 2015-08-19
RU2725890C2 (ru) 2020-07-07
AU2010327380A1 (en) 2012-05-31
CA2781593A1 (en) 2011-06-09
SI2506859T1 (sl) 2016-10-28
EP2506859B1 (en) 2016-05-04
US20120244198A1 (en) 2012-09-27
PT2506859T (pt) 2016-08-12
RU2012125200A (ru) 2014-01-20
HRP20160835T1 (hr) 2016-09-23
KR20120130166A (ko) 2012-11-29
BR112012012997B8 (pt) 2021-05-25
US20180022833A1 (en) 2018-01-25
HUE030071T2 (en) 2017-04-28
EP2506859A4 (en) 2013-10-23
AU2010327380B2 (en) 2014-11-27
LT2506859T (lt) 2016-09-26
PL2506859T3 (pl) 2016-11-30

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