WO2012016042A3 - Glatiramer acetate molecular weight markers - Google Patents

Glatiramer acetate molecular weight markers Download PDF

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Publication number
WO2012016042A3
WO2012016042A3 PCT/US2011/045724 US2011045724W WO2012016042A3 WO 2012016042 A3 WO2012016042 A3 WO 2012016042A3 US 2011045724 W US2011045724 W US 2011045724W WO 2012016042 A3 WO2012016042 A3 WO 2012016042A3
Authority
WO
WIPO (PCT)
Prior art keywords
molecular weight
glatiramer acetate
weight markers
acetate molecular
markers
Prior art date
Application number
PCT/US2011/045724
Other languages
French (fr)
Other versions
WO2012016042A2 (en
Inventor
Santhanakrishnan Srinivasan
Karthik Ramasamy
Chakravarthula Kalyan Narasimham Nallam
Yagna Kiran Kumar Komaravolu
Sudheer Reddy Kallam
Bala Harsha Vardhan Ganji
Ravindra Chary Bathoju
Basanthi Devi
Original Assignee
Dr. Reddy's Laboratories Ltd.
Dr. Reddy's Laboratories, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2013521976A priority Critical patent/JP2013535474A/en
Priority to RU2013108828/15A priority patent/RU2013108828A/en
Priority to CN201180041836.0A priority patent/CN103080747B/en
Priority to CA2806997A priority patent/CA2806997A1/en
Priority to NZ606723A priority patent/NZ606723A/en
Priority to EP11813184.6A priority patent/EP2598889A4/en
Priority to AU2011282635A priority patent/AU2011282635B2/en
Priority to BR112013002230A priority patent/BR112013002230A2/en
Application filed by Dr. Reddy's Laboratories Ltd., Dr. Reddy's Laboratories, Inc. filed Critical Dr. Reddy's Laboratories Ltd.
Priority to KR1020137003967A priority patent/KR20130043196A/en
Priority to MX2013001150A priority patent/MX2013001150A/en
Priority to US13/812,684 priority patent/US9109006B2/en
Publication of WO2012016042A2 publication Critical patent/WO2012016042A2/en
Publication of WO2012016042A3 publication Critical patent/WO2012016042A3/en
Priority to ZA2013/00980A priority patent/ZA201300980B/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/34—Size selective separation, e.g. size exclusion chromatography, gel filtration, permeation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/105831—Protein or peptide standard or control [e.g., hemoglobin, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

Aspects of the present application relate to molecular weight markers of glatiramer acetate for accurate determination of the average molecular weight of glatiramer acetate.
PCT/US2011/045724 2010-07-29 2011-07-28 Glatiramer acetate molecular weight markers WO2012016042A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
AU2011282635A AU2011282635B2 (en) 2010-07-29 2011-07-28 Glatiramer acetate molecular weight markers
CN201180041836.0A CN103080747B (en) 2010-07-29 2011-07-28 glatiramer acetate molecular weight marker
CA2806997A CA2806997A1 (en) 2010-07-29 2011-07-28 Glatiramer acetate molecular weight markers
NZ606723A NZ606723A (en) 2010-07-29 2011-07-28 Glatiramer acetate molecular weight markers
EP11813184.6A EP2598889A4 (en) 2010-07-29 2011-07-28 Glatiramer acetate molecular weight markers
JP2013521976A JP2013535474A (en) 2010-07-29 2011-07-28 Molecular weight marker for glatiramer acetate
BR112013002230A BR112013002230A2 (en) 2010-07-29 2011-07-28 glatiramer acetate molecular weight markers
RU2013108828/15A RU2013108828A (en) 2010-07-29 2011-07-28 MARKERS OF MOLECULAR MASS OF GLATIAMETER ACETATE
KR1020137003967A KR20130043196A (en) 2010-07-29 2011-07-28 Glatiramer acetate moleuclar weight markers
MX2013001150A MX2013001150A (en) 2010-07-29 2011-07-28 Glatiramer acetate molecular weight markers.
US13/812,684 US9109006B2 (en) 2010-07-29 2011-07-28 Glatiramer acetate molecular weight markers
ZA2013/00980A ZA201300980B (en) 2010-07-29 2013-02-06 Glatiramer acetate molecular weight markers

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN2146CH2010 2010-07-29
IN2146/CHE/2010 2010-07-29
US38936010P 2010-10-04 2010-10-04
US61/389,360 2010-10-04

Publications (2)

Publication Number Publication Date
WO2012016042A2 WO2012016042A2 (en) 2012-02-02
WO2012016042A3 true WO2012016042A3 (en) 2012-05-31

Family

ID=45530721

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/045724 WO2012016042A2 (en) 2010-07-29 2011-07-28 Glatiramer acetate molecular weight markers

Country Status (13)

Country Link
US (1) US9109006B2 (en)
EP (1) EP2598889A4 (en)
JP (1) JP2013535474A (en)
KR (1) KR20130043196A (en)
CN (1) CN103080747B (en)
AU (1) AU2011282635B2 (en)
BR (1) BR112013002230A2 (en)
CA (1) CA2806997A1 (en)
MX (1) MX2013001150A (en)
NZ (1) NZ606723A (en)
RU (1) RU2013108828A (en)
WO (1) WO2012016042A2 (en)
ZA (1) ZA201300980B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9029507B2 (en) 2011-02-14 2015-05-12 Usv Limited Copolymer-1, process for preparation and analytical methods thereof
CN104098655B (en) * 2013-04-09 2018-01-30 深圳翰宇药业股份有限公司 Target polypeptide in mass spectrum for synthesizing acetic acid copaxone
WO2016172855A1 (en) * 2015-04-28 2016-11-03 深圳翰宇药业股份有限公司 High performance liquid chromatography method for polypeptide mixtures
EP3147667B1 (en) * 2015-09-24 2019-06-12 CHEMI S.p.A. Analysis of the molecular weight distribution of complex polypeptide mixtures
EP3600553A4 (en) 2017-03-26 2020-09-02 Mapi Pharma Ltd. Glatiramer depot systems for treating progressive forms of multiple sclerosis
KR102438261B1 (en) * 2017-12-14 2022-08-30 엘지디스플레이 주식회사 Display Device
WO2021124565A1 (en) * 2019-12-20 2021-06-24 株式会社日立ハイテク Molecular weight marker for electrophoresis, nucleic acid fractionation method and nucleic acid size analysis method

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5800808A (en) * 1994-05-24 1998-09-01 Veda Research And Development Co., Ltd. Copolymer-1 improvements in compositions of copolymers
US20030157720A1 (en) * 2002-02-06 2003-08-21 Expression Technologies Inc. Protein standard for estimating size and mass
US20050256046A1 (en) * 1998-09-25 2005-11-17 Yeda Research And Development Co., Ltd. Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use
US20070059798A1 (en) * 2005-09-09 2007-03-15 Alexander Gad Polypeptides useful for molecular weight determinations
US20090111133A1 (en) * 2007-10-31 2009-04-30 Abbott Laboratories Gel Filtration Standard
WO2009070233A1 (en) * 2007-11-26 2009-06-04 Waters Technologies Corporation Internal standards and methods for use in quantitatively measuring analytes in a sample

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6514938B1 (en) * 1998-09-25 2003-02-04 Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use
EP1797109B1 (en) * 2004-09-09 2016-02-24 Yeda Research And Development Co., Ltd. Mixtures of polypeptides, compositions containing and processes for preparing same, and uses thereof
JP5297653B2 (en) * 2004-10-29 2013-09-25 サンド・アクチエンゲゼルシヤフト Manufacturing method of glatiramer
UA93669C2 (en) * 2005-02-02 2011-03-10 Тева Фармасьютикл Индастриз, Лтд. Process for producing polypeptide mixtures using hydrogenolysis
MX2012012489A (en) * 2010-04-27 2012-12-17 Reddys Lab Ltd Dr Preparation of polypeptides and salts thereof.
US9029507B2 (en) * 2011-02-14 2015-05-12 Usv Limited Copolymer-1, process for preparation and analytical methods thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5800808A (en) * 1994-05-24 1998-09-01 Veda Research And Development Co., Ltd. Copolymer-1 improvements in compositions of copolymers
US20050256046A1 (en) * 1998-09-25 2005-11-17 Yeda Research And Development Co., Ltd. Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use
US20030157720A1 (en) * 2002-02-06 2003-08-21 Expression Technologies Inc. Protein standard for estimating size and mass
US20070059798A1 (en) * 2005-09-09 2007-03-15 Alexander Gad Polypeptides useful for molecular weight determinations
US20090111133A1 (en) * 2007-10-31 2009-04-30 Abbott Laboratories Gel Filtration Standard
WO2009070233A1 (en) * 2007-11-26 2009-06-04 Waters Technologies Corporation Internal standards and methods for use in quantitatively measuring analytes in a sample

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2598889A4 *

Also Published As

Publication number Publication date
CA2806997A1 (en) 2012-02-02
AU2011282635B2 (en) 2015-05-28
EP2598889A4 (en) 2014-01-22
JP2013535474A (en) 2013-09-12
CN103080747A (en) 2013-05-01
EP2598889A2 (en) 2013-06-05
KR20130043196A (en) 2013-04-29
US9109006B2 (en) 2015-08-18
ZA201300980B (en) 2014-03-26
NZ606723A (en) 2015-11-27
US20130205877A1 (en) 2013-08-15
CN103080747B (en) 2016-04-27
RU2013108828A (en) 2014-09-10
AU2011282635A1 (en) 2013-02-28
BR112013002230A2 (en) 2016-05-24
MX2013001150A (en) 2013-05-30
WO2012016042A2 (en) 2012-02-02

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