UA105508C2 - Спосіб одержання вакцини проти clostridium difficile - Google Patents
Спосіб одержання вакцини проти clostridium difficileInfo
- Publication number
- UA105508C2 UA105508C2 UAA201108284A UAA201108284A UA105508C2 UA 105508 C2 UA105508 C2 UA 105508C2 UA A201108284 A UAA201108284 A UA A201108284A UA A201108284 A UAA201108284 A UA A201108284A UA 105508 C2 UA105508 C2 UA 105508C2
- Authority
- UA
- Ukraine
- Prior art keywords
- toxin
- production
- vaccines
- clostridium
- cleaving
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
Abstract
Винахід стосується способу одержання вакцини проти Clostridium difficile, що продукують АВ-токсин, який полягає у тому, що (а) культивують Clostridium difficile в умовах, при яких продукується АВ-токсин, і збирають культуру; (б) розщеплюють АВ-токсин ферментативно in vitro з використанням інозитгексафосфату як кофактора, і (в) поєднують композицію, отриману на стадії (б), з фармацевтично прийнятним носієм.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08170591 | 2008-12-03 | ||
PCT/EP2009/066109 WO2010063693A1 (en) | 2008-12-03 | 2009-12-01 | Process for production of vaccines |
Publications (1)
Publication Number | Publication Date |
---|---|
UA105508C2 true UA105508C2 (uk) | 2014-05-26 |
Family
ID=42022135
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201108284A UA105508C2 (uk) | 2008-12-03 | 2009-12-01 | Спосіб одержання вакцини проти clostridium difficile |
Country Status (18)
Country | Link |
---|---|
US (1) | US20110243991A1 (uk) |
EP (1) | EP2373332A1 (uk) |
JP (1) | JP2012510497A (uk) |
KR (1) | KR20110100189A (uk) |
CN (1) | CN102238960B (uk) |
AR (1) | AR074455A1 (uk) |
AU (1) | AU2009324180A1 (uk) |
BR (1) | BRPI0922219A2 (uk) |
CA (1) | CA2737403A1 (uk) |
CL (1) | CL2011001284A1 (uk) |
CO (1) | CO6390040A2 (uk) |
MX (1) | MX2011005758A (uk) |
RU (1) | RU2011126602A (uk) |
SG (1) | SG171934A1 (uk) |
TW (1) | TW201026852A (uk) |
UA (1) | UA105508C2 (uk) |
WO (1) | WO2010063693A1 (uk) |
ZA (1) | ZA201101645B (uk) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2507553T3 (es) * | 2006-08-02 | 2014-10-15 | Johannes Gutenberg-Universität Mainz | Fármaco contra intoxicaciones por LCT |
CA2699435A1 (en) * | 2007-09-14 | 2009-03-19 | Sanofi Pasteur Biologics Co. | Pharmaceutical compositions containing clostridium difficile toxoids a and b |
BR122019017005B1 (pt) | 2011-04-22 | 2022-03-29 | Wyeth Llc | Composições que se relacionam a uma toxina de clostridium difficile mutante |
BR122016023101B1 (pt) | 2012-10-21 | 2022-03-22 | Pfizer Inc | Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile |
US8909605B1 (en) * | 2013-02-28 | 2014-12-09 | Emc Corporation | Method and system for accelerating data movement using change information concerning difference between current and previous data movements |
CN105451762A (zh) * | 2013-04-22 | 2016-03-30 | 俄克拉荷马州大学评议会 | 艰难梭菌疫苗及使用方法 |
CN109865135A (zh) * | 2019-03-18 | 2019-06-11 | 宁波大学 | 一种银鲳美人鱼发光杆菌和灿烂弧菌联合灭活疫苗 |
KR102376876B1 (ko) * | 2020-04-09 | 2022-03-21 | 대진대학교 산학협력단 | 무독성의 클로스트리디움 디피실 독소단백질-단편 및 이의 용도 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6967088B1 (en) * | 1995-03-16 | 2005-11-22 | Allergan, Inc. | Soluble recombinant botulinum toxin proteins |
JPH11510793A (ja) * | 1995-07-07 | 1999-09-21 | オラバックス インク. | 胃腸病に対する鼻腔内ワクチン接種 |
JP2002542169A (ja) * | 1999-04-09 | 2002-12-10 | テクラブ, インコーポレイテッド | Clostridiumdifficileに対する、組換え毒素A/毒素Bワクチン |
US7226597B2 (en) * | 2002-06-17 | 2007-06-05 | The Board Of Regents Of The University Of Oklahoma | Mutants of Clostridium difficile toxin B and methods of use |
WO2007146139A2 (en) * | 2006-06-08 | 2007-12-21 | Cornell Research Foundation, Inc. | Codon-optimized dna molecules encoding the receptor binding domains of clostridium difficile toxins a and b |
ES2507553T3 (es) * | 2006-08-02 | 2014-10-15 | Johannes Gutenberg-Universität Mainz | Fármaco contra intoxicaciones por LCT |
-
2009
- 2009-12-01 RU RU2011126602/10A patent/RU2011126602A/ru not_active Application Discontinuation
- 2009-12-01 BR BRPI0922219A patent/BRPI0922219A2/pt not_active IP Right Cessation
- 2009-12-01 EP EP09775142A patent/EP2373332A1/en not_active Withdrawn
- 2009-12-01 MX MX2011005758A patent/MX2011005758A/es not_active Application Discontinuation
- 2009-12-01 US US13/126,186 patent/US20110243991A1/en not_active Abandoned
- 2009-12-01 WO PCT/EP2009/066109 patent/WO2010063693A1/en active Application Filing
- 2009-12-01 UA UAA201108284A patent/UA105508C2/uk unknown
- 2009-12-01 CA CA2737403A patent/CA2737403A1/en not_active Abandoned
- 2009-12-01 CN CN200980148516.8A patent/CN102238960B/zh not_active Expired - Fee Related
- 2009-12-01 JP JP2011538987A patent/JP2012510497A/ja active Pending
- 2009-12-01 AU AU2009324180A patent/AU2009324180A1/en not_active Abandoned
- 2009-12-01 KR KR1020117008708A patent/KR20110100189A/ko not_active Application Discontinuation
- 2009-12-01 SG SG2011040409A patent/SG171934A1/en unknown
- 2009-12-02 TW TW098141177A patent/TW201026852A/zh unknown
- 2009-12-02 AR ARP090104651A patent/AR074455A1/es active Pending
-
2011
- 2011-03-03 ZA ZA2011/01645A patent/ZA201101645B/en unknown
- 2011-05-31 CL CL2011001284A patent/CL2011001284A1/es unknown
- 2011-06-02 CO CO11068894A patent/CO6390040A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN102238960A (zh) | 2011-11-09 |
TW201026852A (en) | 2010-07-16 |
WO2010063693A1 (en) | 2010-06-10 |
CA2737403A1 (en) | 2010-06-10 |
ZA201101645B (en) | 2011-11-30 |
US20110243991A1 (en) | 2011-10-06 |
CN102238960B (zh) | 2014-04-23 |
AU2009324180A1 (en) | 2010-06-10 |
RU2011126602A (ru) | 2013-01-10 |
CO6390040A2 (es) | 2012-02-29 |
CL2011001284A1 (es) | 2011-09-16 |
BRPI0922219A2 (pt) | 2018-10-23 |
KR20110100189A (ko) | 2011-09-09 |
MX2011005758A (es) | 2011-06-28 |
JP2012510497A (ja) | 2012-05-10 |
AR074455A1 (es) | 2011-01-19 |
EP2373332A1 (en) | 2011-10-12 |
SG171934A1 (en) | 2011-07-28 |
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