TWI921490B - 哺乳動物ｓｌｃ６ａ１９功能之小分子抑制劑 - Google Patents

哺乳動物ｓｌｃ６ａ１９功能之小分子抑制劑

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Publication number
TWI921490B
TWI921490B TW111108813A TW111108813A TWI921490B TW I921490 B TWI921490 B TW I921490B TW 111108813 A TW111108813 A TW 111108813A TW 111108813 A TW111108813 A TW 111108813A TW I921490 B TWI921490 B TW I921490B
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TW
Taiwan
Prior art keywords
methyl
mhz
nmr
hexahydropyridin
urea
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TW111108813A
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English (en)
Chinese (zh)
Other versions
TW202302575A (zh
Inventor
狄恩 Ｇ 布朗
價瑟琳 Ｌ 韓德森
爵雅凡妮 幕斯品托
約書亞 Ｅ 維格
隆 Ｖ 阮
尼可拉斯 波琳
米切爾 Ｔ 安塔萊克
萊恩 Ａ 霍利博
Original Assignee
美商杰那醫療公司
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Publication of TW202302575A publication Critical patent/TW202302575A/zh
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Publication of TWI921490B publication Critical patent/TWI921490B/zh

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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL305262A (en) 2021-03-10 2023-10-01 Jnana Therapeutics Inc Small molecule inhibitors of mammalian SLC6A19 function
HUE070709T2 (hu) 2021-08-18 2025-06-28 Nurix Therapeutics Inc Interleukin-1 receptorhoz kapcsolódó kinázok kétfunkciós lebontói és terápiás alkalmazásuk
US20250084054A1 (en) * 2021-12-22 2025-03-13 Janna Therapeutics Inc Small molecule inhibitors of mammalian slc6a19 function
KR20240154642A (ko) 2022-02-28 2024-10-25 아지오스 파마슈티컬스 아이엔씨. 페닐알라닌 하이드록실라아제 돌연변이의 안정화에 유용한 화합물 및 방법
EP4554584A4 (en) * 2022-07-14 2026-07-15 Jnana Therapeutics Inc SMALL MOLECULES THAT INHIBIT SLC6A19 FUNCTION IN A MAMMAL
CA3267536A1 (en) * 2022-09-14 2024-03-21 Jnana Therapeutics Inc. DOSING REGIMEN FOR THE TREATMENT OF PKU WITH A PIPERIDINE INHIBITOR OF THE SLC6A19 FUNCTION
EP4622960A1 (en) * 2022-11-22 2025-10-01 Maze Therapeutics, Inc. Inhibitors of solute carrier family 6a member 19 (slc6a19) and methods of use thereof
EP4626420A1 (en) * 2022-11-30 2025-10-08 Jnana Therapeutics Inc. Crystalline forms of a piperidine inhibitor of slc6a19 function
CN121487736A (zh) * 2023-06-14 2026-02-06 杰那医疗公司 Slc6a19功能的哌啶抑制剂
CN121399098A (zh) 2023-06-30 2026-01-23 赛诺菲 取代的环状化合物以及治疗苯丙酮尿症和其他氨基酸尿症的方法
KR20260049549A (ko) * 2023-08-11 2026-04-14 제이나나 테라퓨틱스 인코포레이티드 Slc6a19 기능의 바이사이클릭 헤테로아릴 함유 피페리딘 억제제
TW202515556A (zh) * 2023-08-17 2025-04-16 美商杰那醫療公司 Ｓｌｃ６ａ１９功能之含萘基哌啶抑制劑
WO2025049658A1 (en) * 2023-08-30 2025-03-06 Agios Pharmaceuticals, Inc. 4-pyrazolo[1,5-a]pyridin-2-yl-4,5,6,7-tetrahydro-1 h-imidazo[4,5-c]pyridine derivatives as mutant pah protein stabilizers for the treatment of phenylketonuria
WO2025214397A1 (zh) * 2024-04-10 2025-10-16 长春金赛药业有限责任公司 Slc6a19抑制剂化合物、药物组合物及其制备方法和应用
US20250346567A1 (en) * 2024-05-13 2025-11-13 Pfizer Inc. Substituted pyridine and phenyl compounds
US12630562B2 (en) 2024-08-07 2026-05-19 Arcus Biosciences, Inc. Piperidylurea compounds and methods of use thereof
WO2026038155A1 (en) * 2024-08-16 2026-02-19 Pfizer Inc. Substituted pyridine compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019046303A1 (en) * 2017-08-28 2019-03-07 The Trustees Of Columbia University In The City Of New York METHOD FOR PREDICTING PATIENT RESPONSE TO SLC MODULATOR PROCESSING

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6750348B1 (en) 1999-03-24 2004-06-15 Anormed, Inc. Chemokine receptor binding heterocyclic compounds
FR2793248B1 (fr) 1999-05-03 2001-06-29 Adir Nouveaux derives de 2,3-methano-aminoacides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6500844B1 (en) 1999-06-11 2002-12-31 Merck & Co., Inc. Cyclopentyl modulators of chemokine receptor activity
MXPA03002263A (es) * 2000-09-14 2003-06-24 Schering Corp Antagonistas de receptor de neuropeptido y y5 de urea sustituidos.
US6894063B2 (en) * 2000-09-14 2005-05-17 Schering Corporation Substituted urea neuropeptide Y Y5 Receptor antagonists
US20050043545A1 (en) 2001-11-02 2005-02-24 Gianpalol Bravi 4-(5-Membered)-heteroaryl acyl pyrrolidine derivatives as hcv inhibitors
WO2003093436A2 (en) 2002-04-30 2003-11-13 University Of Florida Treatment for phenylketonuria
BRPI0506662B8 (pt) * 2004-01-06 2021-05-25 Novo Nordisk As compostos ativadores de glucoquinase
JP2009507855A (ja) * 2005-09-08 2009-02-26 スミスクライン・ビーチャム・コーポレイション 非環式１，４−ジアミンおよびその使用
WO2007115232A2 (en) 2006-03-30 2007-10-11 Chemocentryx, Inc. Cxcr4 modulators
US8329159B2 (en) 2006-08-11 2012-12-11 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
JP2010521456A (ja) 2007-03-13 2010-06-24 アレテ セラピューティクス， インコーポレイテッド 可溶性エポキシドヒドロラーゼ阻害剤
JP2010180177A (ja) * 2009-02-06 2010-08-19 Dainippon Sumitomo Pharma Co Ltd 環状アミノピラゾールアミド誘導体
FR2944206B1 (fr) 2009-04-09 2012-12-28 Sanofi Aventis Applications therapeutiques dans le domaine cardiovasculaire de derives de quinazolinedione
WO2011060396A1 (en) 2009-11-16 2011-05-19 Schering Corporation Aliphatic amines based heterocycles useful as hiv entry blockers
WO2011060397A1 (en) 2009-11-16 2011-05-19 Schering Corporation Substituted amino heterocycles useful as hiv antagonists
WO2012113103A1 (en) 2011-02-25 2012-08-30 Helsinn Healthcare S.A. Asymmetric ureas and medical uses thereof
IN2014DN10328A (enExample) 2012-06-20 2015-08-07 Sandoz Ag
BR112015023922A2 (pt) * 2013-03-15 2017-07-18 Als Mountain Llc composição farmacêutica compreendendo um ativador de ampk e um agente serotonérgico e métodos de uso destes
AU2014287209B2 (en) * 2013-07-09 2019-01-24 Dana-Farber Cancer Institute, Inc. Kinase inhibitors for the treatment of disease
TWI690512B (zh) 2014-03-07 2020-04-11 瑞士商赫爾辛保健股份有限公司 對位取代的不對稱脲及其醫療用途
WO2016095089A1 (en) 2014-12-15 2016-06-23 Merck Sharp & Dohme Corp. Erk inhibitors
TWI698436B (zh) 2014-12-30 2020-07-11 美商佛瑪治療公司 作為泛素特異性蛋白酶７抑制劑之吡咯并及吡唑并嘧啶
WO2018112136A1 (en) * 2016-12-15 2018-06-21 Ariad Pharmaceuticals, Inc. Aminothiazole compounds as c-kit inhibitors
WO2019040106A2 (en) * 2017-08-21 2019-02-28 Acadia Pharmaceuticals Inc. COMPOUNDS, RELATED SALTS AND METHODS FOR THE TREATMENT OF DISEASES
TWI834637B (zh) 2018-03-01 2024-03-11 日商武田藥品工業有限公司 六氫吡啶基-3-(芳氧基)丙醯胺及丙酸酯
GB201809050D0 (en) 2018-06-01 2018-07-18 E Therapeutics Plc Modulators of tryptophan catabolism
US12698259B2 (en) 2018-10-15 2026-08-04 Dana-Farber Cancer Institute, Inc. Transcriptional enhanced associate domain (TEAD) transcription factor inhibitors and uses thereof
CN111978311B (zh) 2019-05-21 2024-05-31 中国科学院上海有机化学研究所 一类细胞程序性坏死抑制剂及其制备方法和用途
CN114269719A (zh) 2019-06-28 2022-04-01 Rti国际 作为cb1变构调节剂的脲衍生物
BR112022010895A2 (pt) 2019-12-04 2022-09-06 Omeros Corp Composto, composição farmacêutica, e, método para tratar uma doença ou distúrbio associado à serina protease-2 associada à lectina de ligação ao manan
AU2022212469B2 (en) 2021-01-27 2026-04-30 Intervet International B.V. Antiparasitic compounds
IL305752A (en) 2021-03-10 2023-11-01 Dice Molecules Sv Inc INTEGRIN INHIBITORS OF ALPHA V BETA 6 AND ALPHA V BETA 1 AND THEIR USES
IL305262A (en) * 2021-03-10 2023-10-01 Jnana Therapeutics Inc Small molecule inhibitors of mammalian SLC6A19 function
TW202309022A (zh) 2021-04-13 2023-03-01 美商努法倫特公司 用於治療具egfr突變之癌症之胺基取代雜環
WO2023283213A1 (en) 2021-07-07 2023-01-12 Incyte Corporation Tricyclic compounds as inhibitors of kras
KR20240041987A (ko) 2021-07-28 2024-04-01 누라 바이오, 인크. Sarm1 억제제로서 치환된 피리딘 유도체
TW202321229A (zh) 2021-08-18 2023-06-01 美商富曼西公司 殺真菌的取代的雜環化合物
HUE070709T2 (hu) 2021-08-18 2025-06-28 Nurix Therapeutics Inc Interleukin-1 receptorhoz kapcsolódó kinázok kétfunkciós lebontói és terápiás alkalmazásuk
IL310368A (en) 2021-08-18 2024-03-01 Chemocentryx Inc Arylsulfonyl(hydroxy)piperidines as CCR6 inhibitors
TW202325288A (zh) 2021-11-05 2023-07-01 英商喜翠克斯治療有限公司 新穎化合物
CA3241713A1 (en) 2021-12-22 2023-06-29 Irene BASSANETTI Triazolone derivative salt as neutrophil elastase inhibitor
AU2022418385A1 (en) 2021-12-22 2024-05-30 Sitryx Therapeutics Limited Phthalazine derivatives as pyruvate kinase modulators
WO2023122140A1 (en) 2021-12-22 2023-06-29 Synnovation Therapeutics, Inc. Parp1 inhibitors
CR20240297A (es) 2021-12-22 2024-09-18 Incyte Corp Sales y formas sólidas de un inhibidor de fgfr y procesos para su preparación
US20250084054A1 (en) 2021-12-22 2025-03-13 Janna Therapeutics Inc Small molecule inhibitors of mammalian slc6a19 function
US12030866B2 (en) 2021-12-23 2024-07-09 Springworks Therapeutics, Inc. 2-pyrazole anilines and related analogs for inhibiting YAP/TAZ-TEAD
CN120076801A (zh) 2022-07-14 2025-05-30 杰那医疗公司 哺乳动物slc6a19功能的小分子抑制剂
EP4554584A4 (en) 2022-07-14 2026-07-15 Jnana Therapeutics Inc SMALL MOLECULES THAT INHIBIT SLC6A19 FUNCTION IN A MAMMAL
JP2025531154A (ja) 2022-09-14 2025-09-19 ジュニャーナ セラピューティクス インコーポレイテッド 哺乳類ｓｌｃ６ａ１９機能のコレクターを用いるｐｋｕの処置
EP4587022A1 (en) 2022-09-14 2025-07-23 Jnana Therapeutics Inc. Treating pku with spiro-substituted and other piperidine inhibitors of slc6a19 function
CA3267536A1 (en) 2022-09-14 2024-03-21 Jnana Therapeutics Inc. DOSING REGIMEN FOR THE TREATMENT OF PKU WITH A PIPERIDINE INHIBITOR OF THE SLC6A19 FUNCTION
EP4622960A1 (en) 2022-11-22 2025-10-01 Maze Therapeutics, Inc. Inhibitors of solute carrier family 6a member 19 (slc6a19) and methods of use thereof
EP4626420A1 (en) 2022-11-30 2025-10-08 Jnana Therapeutics Inc. Crystalline forms of a piperidine inhibitor of slc6a19 function
CN121487736A (zh) 2023-06-14 2026-02-06 杰那医疗公司 Slc6a19功能的哌啶抑制剂
KR20260049549A (ko) 2023-08-11 2026-04-14 제이나나 테라퓨틱스 인코포레이티드 Slc6a19 기능의 바이사이클릭 헤테로아릴 함유 피페리딘 억제제
TW202515556A (zh) 2023-08-17 2025-04-16 美商杰那醫療公司 Ｓｌｃ６ａ１９功能之含萘基哌啶抑制劑

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019046303A1 (en) * 2017-08-28 2019-03-07 The Trustees Of Columbia University In The City Of New York METHOD FOR PREDICTING PATIENT RESPONSE TO SLC MODULATOR PROCESSING

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