BR112023018277A2 - Inibidores de pequenas moléculas da função de slc6a19 de mamíferos - Google Patents

Inibidores de pequenas moléculas da função de slc6a19 de mamíferos

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Publication number
BR112023018277A2
BR112023018277A2 BR112023018277A BR112023018277A BR112023018277A2 BR 112023018277 A2 BR112023018277 A2 BR 112023018277A2 BR 112023018277 A BR112023018277 A BR 112023018277A BR 112023018277 A BR112023018277 A BR 112023018277A BR 112023018277 A2 BR112023018277 A2 BR 112023018277A2
Authority
BR
Brazil
Prior art keywords
slc6a19
mammalian
function
small molecule
molecule inhibitors
Prior art date
Application number
BR112023018277A
Other languages
English (en)
Inventor
g brown Dean
Giovanni Muncipinto
L Henderson Jaclyn
E Zweig Joshua
V Nguyen Long
T Antalek Mitchell
Nicholas Pullen
A Hollibaugh Ryan
Original Assignee
Jnana Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jnana Therapeutics Inc filed Critical Jnana Therapeutics Inc
Publication of BR112023018277A2 publication Critical patent/BR112023018277A2/pt

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A—HUMAN NECESSITIES
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    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
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Abstract

inibidores de pequenas moléculas da função de slc6a19 de mamíferos. a presente invenção refere-se a compostos, composições e métodos úteis para tratar ou prevenir uma doença ou distúrbio associado a níveis anormais de aminoácidos por modulação do transporte de slc6a19.
BR112023018277A 2021-03-10 2022-03-09 Inibidores de pequenas moléculas da função de slc6a19 de mamíferos BR112023018277A2 (pt)

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US202263308790P 2022-02-10 2022-02-10
PCT/US2022/019513 WO2022192370A1 (en) 2021-03-10 2022-03-09 Small molecule inhibitors of mammalian slc6a19 function

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WO2023122267A2 (en) * 2021-12-22 2023-06-29 Jnana Therapeutics Inc. Small molecule inhibitors of mammalian slc6a19 function
WO2024058926A1 (en) * 2022-09-14 2024-03-21 Jnana Therapeutics Inc. Dosing regimen for treating pku with a piperidine inhibitor of slc6a19 function
WO2024112830A1 (en) * 2022-11-22 2024-05-30 Maze Therapeutics, Inc. Inhibitors of solute carrier family 6a member 19 (slc6a19) and methods of use thereof
WO2024118721A1 (en) * 2022-11-30 2024-06-06 Jnana Therapeutics Inc. Crystalline forms of a piperidine inhibitor of slc6a19 function

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WO2019040106A2 (en) * 2017-08-21 2019-02-28 Acadia Pharmaceuticals Inc. COMPOUNDS, RELATED SALTS AND METHODS FOR THE TREATMENT OF DISEASES
WO2019046303A1 (en) * 2017-08-28 2019-03-07 The Trustees Of Columbia University In The City Of New York METHOD FOR PREDICTING PATIENT RESPONSE TO SLC MODULATOR PROCESSING

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US20240208923A1 (en) 2024-06-27
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DOP2023000178A (es) 2023-12-29
UY39667A (es) 2022-10-31
PE20231987A1 (es) 2023-12-12
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CA3209914A1 (en) 2022-09-15
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