BR112023018277A2 - SMALL MOLECULE INHIBITORS OF MAMMALIAN SLC6A19 FUNCTION - Google Patents
SMALL MOLECULE INHIBITORS OF MAMMALIAN SLC6A19 FUNCTIONInfo
- Publication number
- BR112023018277A2 BR112023018277A2 BR112023018277A BR112023018277A BR112023018277A2 BR 112023018277 A2 BR112023018277 A2 BR 112023018277A2 BR 112023018277 A BR112023018277 A BR 112023018277A BR 112023018277 A BR112023018277 A BR 112023018277A BR 112023018277 A2 BR112023018277 A2 BR 112023018277A2
- Authority
- BR
- Brazil
- Prior art keywords
- slc6a19
- mammalian
- function
- small molecule
- molecule inhibitors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000003384 small molecules Chemical class 0.000 title abstract 2
- 102000005025 SLC6A19 Human genes 0.000 title 1
- 108060007758 SLC6A19 Proteins 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
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- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
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Abstract
inibidores de pequenas moléculas da função de slc6a19 de mamíferos. a presente invenção refere-se a compostos, composições e métodos úteis para tratar ou prevenir uma doença ou distúrbio associado a níveis anormais de aminoácidos por modulação do transporte de slc6a19.small molecule inhibitors of mammalian slc6a19 function. The present invention relates to compounds, compositions and methods useful for treating or preventing a disease or disorder associated with abnormal amino acid levels by modulating slc6a19 transport.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
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US202163159271P | 2021-03-10 | 2021-03-10 | |
US202163226551P | 2021-07-28 | 2021-07-28 | |
US202163234487P | 2021-08-18 | 2021-08-18 | |
US202163292815P | 2021-12-22 | 2021-12-22 | |
US202263308790P | 2022-02-10 | 2022-02-10 | |
PCT/US2022/019513 WO2022192370A1 (en) | 2021-03-10 | 2022-03-09 | Small molecule inhibitors of mammalian slc6a19 function |
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BR112023018277A BR112023018277A2 (en) | 2021-03-10 | 2022-03-09 | SMALL MOLECULE INHIBITORS OF MAMMALIAN SLC6A19 FUNCTION |
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CL (1) | CL2023002581A1 (en) |
CO (1) | CO2023013218A2 (en) |
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TW (1) | TW202302575A (en) |
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WO2023122267A2 (en) * | 2021-12-22 | 2023-06-29 | Jnana Therapeutics Inc. | Small molecule inhibitors of mammalian slc6a19 function |
WO2024058926A1 (en) * | 2022-09-14 | 2024-03-21 | Jnana Therapeutics Inc. | Dosing regimen for treating pku with a piperidine inhibitor of slc6a19 function |
WO2024112830A1 (en) * | 2022-11-22 | 2024-05-30 | Maze Therapeutics, Inc. | Inhibitors of solute carrier family 6a member 19 (slc6a19) and methods of use thereof |
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WO2019040106A2 (en) * | 2017-08-21 | 2019-02-28 | Acadia Pharmaceuticals Inc. | Compounds, salts thereof and methods for treatment of diseases |
WO2019046303A1 (en) * | 2017-08-28 | 2019-03-07 | The Trustees Of Columbia University In The City Of New York | A method for predicting a subject's response to slc modulator therapy |
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ECSP23075523A (en) | 2024-01-31 |
JP2024509818A (en) | 2024-03-05 |
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WO2022192370A1 (en) | 2022-09-15 |
DOP2023000178A (en) | 2023-12-29 |
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CO2023013218A2 (en) | 2024-02-05 |
PE20231987A1 (en) | 2023-12-12 |
CA3209914A1 (en) | 2022-09-15 |
IL305262A (en) | 2023-10-01 |
MX2023010467A (en) | 2023-11-22 |
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EP4304586A1 (en) | 2024-01-17 |
CR20230467A (en) | 2024-02-20 |
KR20230162935A (en) | 2023-11-29 |
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