TWI912331B - 抗tau抗體 - Google Patents

抗tau抗體

Info

Publication number
TWI912331B
TWI912331B TW110125334A TW110125334A TWI912331B TW I912331 B TWI912331 B TW I912331B TW 110125334 A TW110125334 A TW 110125334A TW 110125334 A TW110125334 A TW 110125334A TW I912331 B TWI912331 B TW I912331B
Authority
TW
Taiwan
Prior art keywords
seq
specific binding
sequence shown
amino acid
binding molecule
Prior art date
Application number
TW110125334A
Other languages
English (en)
Chinese (zh)
Other versions
TW202214686A (zh
Inventor
索曼 蘇木亞 巴利易爾
安德魯 賈斯汀 雷德克里夫 波爾特
查理斯 羅伯特 哈靈頓
克勞蒂 米歇爾 威斯奇克
穆罕默德 爾拉史杜
路易斯 克爾克 潘妮
理查 洛夫特豪斯
Original Assignee
英商Ｇｔ創新公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 英商Ｇｔ創新公司 filed Critical 英商Ｇｔ創新公司
Publication of TW202214686A publication Critical patent/TW202214686A/zh
Application granted granted Critical
Publication of TWI912331B publication Critical patent/TWI912331B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Psychiatry (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
TW110125334A 2020-07-10 2021-07-09 抗tau抗體 TWI912331B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB2010652.2A GB202010652D0 (en) 2020-07-10 2020-07-10 Anti-tau antibodies
GBGB2010652.2 2020-07-10

Publications (2)

Publication Number Publication Date
TW202214686A TW202214686A (zh) 2022-04-16
TWI912331B true TWI912331B (zh) 2026-01-21

Family

ID=72140057

Family Applications (1)

Application Number Title Priority Date Filing Date
TW110125334A TWI912331B (zh) 2020-07-10 2021-07-09 抗tau抗體

Country Status (10)

Country Link
US (1) US20230257452A1 (https=)
EP (1) EP4178980A1 (https=)
JP (1) JP7796719B2 (https=)
KR (1) KR20230038721A (https=)
CN (1) CN116194479A (https=)
AU (1) AU2021306653A1 (https=)
CA (1) CA3185175A1 (https=)
GB (1) GB202010652D0 (https=)
TW (1) TWI912331B (https=)
WO (1) WO2022008719A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20250147051A1 (en) * 2022-01-12 2025-05-08 Gtinvent Limited Method for detecting a tau protein in a saliva sample
KR20240134175A (ko) * 2022-01-12 2024-09-06 지틴벤트 리미티드 샘플에서 타우(tau) 단백질 단편을 검출하기 위한 방법

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015004163A1 (en) * 2013-07-08 2015-01-15 Adx Neurosciences Anti-tau monoclonal antibodies
CN105324394A (zh) * 2012-12-21 2016-02-10 比奥根Ma公司 人抗-tau抗体
CN105899230A (zh) * 2013-11-27 2016-08-24 伊皮埃里安股份有限公司 治疗tau病变的方法
TW201821438A (zh) * 2016-12-07 2018-06-16 美商建南德克公司 抗-ｔａｕ抗體及使用方法
TW201836640A (zh) * 2017-03-28 2018-10-16 美商建南德克公司 治療神經退化性疾病之方法
CN109562167A (zh) * 2016-08-09 2019-04-02 伊莱利利公司 联合治疗

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9506197D0 (en) 1995-03-27 1995-05-17 Hoffmann La Roche Inhibition of tau-tau association.
GB0106953D0 (en) 2001-03-20 2001-05-09 Univ Aberdeen Neufofibrillary labels
US20140303041A1 (en) * 2004-04-15 2014-10-09 University Of Florida Research Foundation Inc. In vitro diagnostic devices for nervous system injury and other neural disorders
ES2349322T7 (es) 2006-03-29 2019-10-17 Wista Lab Ltd Sales de 3,7-diamino-10H-fenotiazina y su utilización
WO2007110630A1 (en) 2006-03-29 2007-10-04 Wista Laboratories Ltd. Thioninium compounds and their use
JP5898701B2 (ja) 2011-02-11 2016-04-13 ウィスタ ラボラトリーズ リミテッド フェノチアジンジアミニウム塩およびそれらの使用
US20250147051A1 (en) * 2022-01-12 2025-05-08 Gtinvent Limited Method for detecting a tau protein in a saliva sample

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105324394A (zh) * 2012-12-21 2016-02-10 比奥根Ma公司 人抗-tau抗体
WO2015004163A1 (en) * 2013-07-08 2015-01-15 Adx Neurosciences Anti-tau monoclonal antibodies
CN105899230A (zh) * 2013-11-27 2016-08-24 伊皮埃里安股份有限公司 治疗tau病变的方法
CN109562167A (zh) * 2016-08-09 2019-04-02 伊莱利利公司 联合治疗
TW201821438A (zh) * 2016-12-07 2018-06-16 美商建南德克公司 抗-ｔａｕ抗體及使用方法
TW201836640A (zh) * 2017-03-28 2018-10-16 美商建南德克公司 治療神經退化性疾病之方法

Also Published As

Publication number Publication date
AU2021306653A1 (en) 2023-03-02
US20230257452A1 (en) 2023-08-17
TW202214686A (zh) 2022-04-16
JP2023533768A (ja) 2023-08-04
EP4178980A1 (en) 2023-05-17
GB202010652D0 (en) 2020-08-26
KR20230038721A (ko) 2023-03-21
JP7796719B2 (ja) 2026-01-09
CA3185175A1 (en) 2022-01-13
WO2022008719A1 (en) 2022-01-13
CN116194479A (zh) 2023-05-30

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