TWI904982B - 腫瘤治療用醫藥組成物 - Google Patents

腫瘤治療用醫藥組成物

Info

Publication number
TWI904982B
TWI904982B TW113150347A TW113150347A TWI904982B TW I904982 B TWI904982 B TW I904982B TW 113150347 A TW113150347 A TW 113150347A TW 113150347 A TW113150347 A TW 113150347A TW I904982 B TWI904982 B TW I904982B
Authority
TW
Taiwan
Prior art keywords
eribulin
cancer
liposome
antibody
administered
Prior art date
Application number
TW113150347A
Other languages
English (en)
Chinese (zh)
Other versions
TW202515533A (zh
Inventor
仙波太郎
船橋泰博
鈴木拓也
Original Assignee
日商衛材R&D企管股份有限公司
日商小野藥品工業股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 日商衛材R&D企管股份有限公司, 日商小野藥品工業股份有限公司 filed Critical 日商衛材R&D企管股份有限公司
Publication of TW202515533A publication Critical patent/TW202515533A/zh
Application granted granted Critical
Publication of TWI904982B publication Critical patent/TWI904982B/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
TW113150347A 2019-07-26 2020-07-24 腫瘤治療用醫藥組成物 TWI904982B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2019138041 2019-07-26
JP2019-138041 2019-07-26
US16/835,719 US11083705B2 (en) 2019-07-26 2020-03-31 Pharmaceutical composition for treating tumor
US16/835,719 2020-03-31

Publications (2)

Publication Number Publication Date
TW202515533A TW202515533A (zh) 2025-04-16
TWI904982B true TWI904982B (zh) 2025-11-11

Family

ID=74187564

Family Applications (4)

Application Number Title Priority Date Filing Date
TW113150347A TWI904982B (zh) 2019-07-26 2020-07-24 腫瘤治療用醫藥組成物
TW113150346A TWI904981B (zh) 2019-07-26 2020-07-24 腫瘤治療用醫藥組成物
TW109125099A TWI865566B (zh) 2019-07-26 2020-07-24 腫瘤治療用醫藥組成物
TW113150348A TWI904983B (zh) 2019-07-26 2020-07-24 腫瘤治療用醫藥組成物

Family Applications After (3)

Application Number Title Priority Date Filing Date
TW113150346A TWI904981B (zh) 2019-07-26 2020-07-24 腫瘤治療用醫藥組成物
TW109125099A TWI865566B (zh) 2019-07-26 2020-07-24 腫瘤治療用醫藥組成物
TW113150348A TWI904983B (zh) 2019-07-26 2020-07-24 腫瘤治療用醫藥組成物

Country Status (14)

Country Link
US (2) US11083705B2 (https=)
EP (1) EP3970745A4 (https=)
JP (1) JP7649742B2 (https=)
KR (1) KR20220041044A (https=)
CN (1) CN113993545A (https=)
BR (1) BR112021026170A2 (https=)
CA (1) CA3143486A1 (https=)
IL (1) IL289213A (https=)
MA (1) MA55982A (https=)
MX (1) MX2021016093A (https=)
PH (1) PH12021553177A1 (https=)
TW (4) TWI904982B (https=)
WO (1) WO2021020336A1 (https=)
ZA (1) ZA202110686B (https=)

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CN102369008B (zh) 2009-03-30 2014-10-29 卫材R&D管理有限公司 脂质体组合物
WO2017188350A1 (ja) 2016-04-28 2017-11-02 エーザイ・アール・アンド・ディー・マネジメント株式会社 腫瘍の成長を抑制する方法
US12036204B2 (en) 2019-07-26 2024-07-16 Eisai R&D Management Co., Ltd. Pharmaceutical composition for treating tumor
CN116407492B (zh) * 2021-12-29 2024-11-05 北京新领先医药科技发展有限公司 一种甲磺酸艾日布林注射液组合物及制备方法

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Also Published As

Publication number Publication date
EP3970745A1 (en) 2022-03-23
BR112021026170A2 (pt) 2022-02-15
AU2020323402A1 (en) 2022-01-27
TW202515533A (zh) 2025-04-16
JPWO2021020336A1 (https=) 2021-02-04
WO2021020336A1 (ja) 2021-02-04
KR20220041044A (ko) 2022-03-31
TW202515532A (zh) 2025-04-16
US20210023047A1 (en) 2021-01-28
TWI904981B (zh) 2025-11-11
TW202515534A (zh) 2025-04-16
ZA202110686B (en) 2022-09-28
IL289213A (en) 2022-02-01
CN113993545A (zh) 2022-01-28
CA3143486A1 (en) 2021-02-04
PH12021553177A1 (en) 2022-11-07
TWI865566B (zh) 2024-12-11
TW202118486A (zh) 2021-05-16
MX2021016093A (es) 2022-02-03
NZ783713A (en) 2025-06-27
MA55982A (fr) 2022-03-23
EP3970745A4 (en) 2023-07-19
US11083705B2 (en) 2021-08-10
JP7649742B2 (ja) 2025-03-21
US20210177802A1 (en) 2021-06-17
TWI904983B (zh) 2025-11-11

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