TWI897846B - 可誘導之嵌合細胞激素受體 - Google Patents

可誘導之嵌合細胞激素受體

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Publication number
TWI897846B
TWI897846B TW108107136A TW108107136A TWI897846B TW I897846 B TWI897846 B TW I897846B TW 108107136 A TW108107136 A TW 108107136A TW 108107136 A TW108107136 A TW 108107136A TW I897846 B TWI897846 B TW I897846B
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Taiwan
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domain
cells
cell
receptor
immune cell
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TW108107136A
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English (en)
Chinese (zh)
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TW201945402A (zh
Inventor
安德魯 羅斯 納格
史賓瑟 帕克
瑞格斯 嘉維爾 費南多 恰佩羅
君慧 林
布拉康 湯瑪士 約翰 凡
Original Assignee
美商異基因治療有限公司
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12Y502/00—Cis-trans-isomerases (5.2)
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    • C12Y502/01008—Peptidylprolyl isomerase (5.2.1.8), i.e. cyclophilin
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  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
TW108107136A 2018-03-02 2019-03-04 可誘導之嵌合細胞激素受體 TWI897846B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862637600P 2018-03-02 2018-03-02
US62/637,600 2018-03-02
PCT/US2019/020340 WO2019169290A1 (en) 2018-03-02 2019-03-01 Inducible chimeric cytokine receptors
WOPCT/US2019/020340 2019-03-01

Publications (2)

Publication Number Publication Date
TW201945402A TW201945402A (zh) 2019-12-01
TWI897846B true TWI897846B (zh) 2025-09-21

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TW108107136A TWI897846B (zh) 2018-03-02 2019-03-04 可誘導之嵌合細胞激素受體

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US (2) US12163169B2 (https=)
EP (1) EP3759132A1 (https=)
JP (2) JP7526101B2 (https=)
KR (2) KR20250123938A (https=)
CN (1) CN111819192A (https=)
AR (1) AR114273A1 (https=)
AU (2) AU2019227979B2 (https=)
BR (1) BR112020017734A2 (https=)
CA (1) CA3091681A1 (https=)
IL (2) IL276831B2 (https=)
MX (2) MX2020009051A (https=)
SG (1) SG11202007771VA (https=)
TW (1) TWI897846B (https=)
WO (1) WO2019169290A1 (https=)

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US12590321B2 (en) 2016-03-19 2026-03-31 Exuma Biotech Corp. Methods and compositions for genetically modifying and expanding lymphocytes and regulating the activity thereof
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AU2019219454A1 (en) 2018-02-09 2020-08-27 National University Of Singapore Activating chimeric receptors and uses thereof in natural killer cell immunotherapy
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EP3844186A4 (en) * 2018-08-29 2022-08-17 National University of Singapore METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS
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