TWI886314B - 抑制ｌｐａ表現之組合物及方法 - Google Patents

抑制ｌｐａ表現之組合物及方法 Download PDF

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TWI886314B
TWI886314B TW110128888A TW110128888A TWI886314B TW I886314 B TWI886314 B TW I886314B TW 110128888 A TW110128888 A TW 110128888A TW 110128888 A TW110128888 A TW 110128888A TW I886314 B TWI886314 B TW I886314B
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lpa
oligonucleotide
galnac
nucleotides
seq
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TW110128888A
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Chinese (zh)
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TW202220673A (zh
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馬克 艾布蘭
包柏 戴爾 布朗
亨立克 Ｔ 杜迪克
韓雯
安東 杜拉諾
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美商戴瑟納製藥股份有限公司
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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TW110128888A 2020-08-05 2021-08-05 抑制ｌｐａ表現之組合物及方法 TWI886314B (zh)

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US202063061676P 2020-08-05 2020-08-05
US63/061,676 2020-08-05
US202063074779P 2020-09-04 2020-09-04
US63/074,779 2020-09-04

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TW202220673A TW202220673A (zh) 2022-06-01
TWI886314B true TWI886314B (zh) 2025-06-11

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TW110128888A TWI886314B (zh) 2020-08-05 2021-08-05 抑制ｌｐａ表現之組合物及方法
TW114118397A TW202535432A (zh) 2020-08-05 2021-08-05 抑制lpa表現之組合物及方法

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US (3) US12435336B2 (https=)
EP (1) EP4192954A1 (https=)
JP (2) JP7476422B2 (https=)
KR (2) KR102812602B1 (https=)
CN (1) CN116323943A (https=)
AU (2) AU2021320550B2 (https=)
BR (1) BR112023001957A2 (https=)
CA (1) CA3185348A1 (https=)
IL (1) IL300338A (https=)
MX (1) MX2023001538A (https=)
TW (2) TWI886314B (https=)
WO (1) WO2022032288A1 (https=)

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CN118685405A (zh) * 2023-06-20 2024-09-24 施能康医药科技(苏州)有限公司 靶向脂蛋白a的核酸及其用途
WO2025064821A2 (en) 2023-09-21 2025-03-27 Ionis Pharmaceuticals, Inc. Compounds and methods for inhibiting lpa
WO2025082058A1 (zh) * 2023-10-16 2025-04-24 润佳(上海)医药技术有限公司 一种抑制LPA基因表达的dsRNA及其用途
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US12435336B2 (en) 2025-10-07
BR112023001957A2 (pt) 2023-04-25
MX2023001538A (es) 2023-03-08
IL300338A (en) 2023-04-01
AU2021320550B2 (en) 2025-11-06
KR20250077604A (ko) 2025-05-30
JP2024081668A (ja) 2024-06-18
US12252691B2 (en) 2025-03-18
KR102812602B1 (ko) 2025-05-28
US20260071219A1 (en) 2026-03-12
EP4192954A1 (en) 2023-06-14
AU2021320550A1 (en) 2023-02-16
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TW202535432A (zh) 2025-09-16
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