TWI878330B - 特異性結合mage-a的抗原結合蛋白 - Google Patents

特異性結合mage-a的抗原結合蛋白 Download PDF

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TWI878330B
TWI878330B TW109125935A TW109125935A TWI878330B TW I878330 B TWI878330 B TW I878330B TW 109125935 A TW109125935 A TW 109125935A TW 109125935 A TW109125935 A TW 109125935A TW I878330 B TWI878330 B TW I878330B
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amino acid
seq
acid sequence
antigen binding
antigen
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TW109125935A
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Chinese (zh)
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TW202120548A (zh
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麥克 胡特
菲立克斯 尤佛多本
賽巴斯汀 邦克
多明尼克 馬友若
馬丁 霍夫曼
加百列 佐拉
莎拉 尤瑟夫
克勞迪亞 瓦那
法蘭克 舒烏貝
海科 舒斯特
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德商英麥提克生物技術股份有限公司
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/44—Antibodies bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4267—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K40/4268—MAGE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P35/02—Antineoplastic agents specific for leukemia
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
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    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
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TW109125935A 2019-08-02 2020-07-31 特異性結合mage-a的抗原結合蛋白 TWI878330B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201962882131P 2019-08-02 2019-08-02
DE102019121007.0A DE102019121007A1 (de) 2019-08-02 2019-08-02 Antigenbindende Proteine, die spezifisch an MAGE-A binden
US62/882,131 2019-08-02
DE102019121007.0 2019-08-02
US201962905782P 2019-09-25 2019-09-25
US62/905,782 2019-09-25

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Publication Number Publication Date
TW202120548A TW202120548A (zh) 2021-06-01
TWI878330B true TWI878330B (zh) 2025-04-01

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US (4) US11840577B2 (enExample)
EP (1) EP4007776A1 (enExample)
JP (2) JP7476298B2 (enExample)
KR (1) KR20220041161A (enExample)
CN (2) CN115925958A (enExample)
AR (1) AR120585A1 (enExample)
AU (1) AU2020324515A1 (enExample)
BR (1) BR112022001923A2 (enExample)
CA (1) CA3148937A1 (enExample)
CL (2) CL2022000252A1 (enExample)
CO (1) CO2022002044A2 (enExample)
CR (1) CR20220086A (enExample)
DE (1) DE102019121007A1 (enExample)
IL (1) IL290268A (enExample)
MX (3) MX2022001422A (enExample)
PE (1) PE20221021A1 (enExample)
PH (1) PH12022550230A1 (enExample)
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ES2898210T3 (es) 2017-07-14 2022-03-04 Immatics Biotechnologies Gmbh Molécula de polipéptido con especificidad dual mejorada
DE102019121007A1 (de) 2019-08-02 2021-02-04 Immatics Biotechnologies Gmbh Antigenbindende Proteine, die spezifisch an MAGE-A binden
GB2615010A (en) * 2020-10-02 2023-07-26 Us Health HLA class II-restricted DQ T cell receptors against RAS with G13D mutation
US12435444B2 (en) 2021-03-09 2025-10-07 Cdr-Life Ag Rabbit-derived antigen binding protein nucleic acid libraries and methods of making the same
MX2023010541A (es) 2021-03-09 2023-11-24 Cdr Life Ag Proteinas de union al antigeno del peptido del mhc mage-a4.
EP4334361A1 (en) 2021-05-05 2024-03-13 Immatics Biotechnologies GmbH Antigen binding proteins specifically binding prame
EP4091627A1 (en) 2021-05-21 2022-11-23 Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft Tcr constructs specific for magea4-derived epitopes
WO2023099606A1 (en) 2021-12-01 2023-06-08 Immunocore Limited Treatment of mage-a4 positive cancer
WO2023148494A1 (en) * 2022-02-03 2023-08-10 University College Cardiff Consultants Limited Novel t-cell receptor
CN114457002B (zh) * 2022-02-23 2023-08-22 中山大学 一种分离细胞外囊泡亚群的方法及其应用
CN119487060A (zh) * 2022-05-02 2025-02-18 帝斯肯医疗公司 多重t细胞受体组合物、组合疗法以及其用途
EP4534554A1 (en) * 2022-06-01 2025-04-09 Corregene Biotechnology Co., Ltd. Mage-a1 specific tcr and use thereof
EP4543911A2 (en) * 2022-06-24 2025-04-30 Amgen Inc. Magea4 specific t cell receptors
WO2024035962A2 (en) * 2022-08-12 2024-02-15 Ingenious Targeting Laboratories Genetically modified non-human having humanized gamma and delta tcr variable genes
CA3264474A1 (en) 2022-09-14 2024-03-21 Cdr-Life Ag MAGE-A4 DOUBLE T LYMPHOCYTE ENGAGEMENT
EP4658678A1 (en) 2023-02-03 2025-12-10 Zelluna Immunotherapy AS Anti-mage-a4 t cell receptors
CN116519936B (zh) * 2023-02-28 2025-11-07 杭州凯保罗生物科技有限公司 用于前列腺癌早期检测的肿瘤自身抗原/抗体组合及应用
TW202506719A (zh) 2023-07-27 2025-02-16 德商艾瑪提克生物技術有限公司 針對mageb2之抗原結合蛋白
WO2025233431A1 (en) 2024-05-07 2025-11-13 Immatics Biotechnologies Gmbh Heteromeric proteins comprising three heteromerization improving substitution, production, combinations and applications thereof
WO2025233420A1 (en) 2024-05-07 2025-11-13 Immatics Biotechnologies Gmbh Use of anti-cancer molecules
GB2641580A (en) 2024-06-07 2025-12-10 T Therapeutics Ltd Tumour-transforming multispecific proteins
CN119529098B (zh) * 2025-01-22 2025-05-30 北京可瑞生物科技有限公司 对mage-a1具有特异性的结合分子和抗cd3的融合蛋白

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