TWI875727B - 有機化合物之結晶形及鹽型及其醫藥組合物 - Google Patents
有機化合物之結晶形及鹽型及其醫藥組合物 Download PDFInfo
- Publication number
- TWI875727B TWI875727B TW108147117A TW108147117A TWI875727B TW I875727 B TWI875727 B TW I875727B TW 108147117 A TW108147117 A TW 108147117A TW 108147117 A TW108147117 A TW 108147117A TW I875727 B TWI875727 B TW I875727B
- Authority
- TW
- Taiwan
- Prior art keywords
- compound
- pharmaceutical composition
- salt
- cancer
- crystalline
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862784083P | 2018-12-21 | 2018-12-21 | |
| US62/784,083 | 2018-12-21 | ||
| US201962791571P | 2019-01-11 | 2019-01-11 | |
| US62/791,571 | 2019-01-11 | ||
| US201962882712P | 2019-08-05 | 2019-08-05 | |
| US62/882,712 | 2019-08-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW202039448A TW202039448A (zh) | 2020-11-01 |
| TWI875727B true TWI875727B (zh) | 2025-03-11 |
Family
ID=69185721
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW108147117A TWI875727B (zh) | 2018-12-21 | 2019-12-20 | 有機化合物之結晶形及鹽型及其醫藥組合物 |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US12297179B2 (enExample) |
| EP (1) | EP3898597A1 (enExample) |
| JP (3) | JP2022515239A (enExample) |
| KR (1) | KR20220035022A (enExample) |
| CN (1) | CN113508108B (enExample) |
| AU (1) | AU2019403396B2 (enExample) |
| BR (1) | BR112021012305A2 (enExample) |
| CA (1) | CA3124401A1 (enExample) |
| CL (1) | CL2021001640A1 (enExample) |
| CO (1) | CO2021009309A2 (enExample) |
| CR (1) | CR20210394A (enExample) |
| GE (2) | GEAP202415700A (enExample) |
| IL (1) | IL284218B1 (enExample) |
| JO (1) | JOP20210147A1 (enExample) |
| MA (1) | MA54541A (enExample) |
| MX (1) | MX2021007536A (enExample) |
| NI (1) | NI202100055A (enExample) |
| PE (2) | PE20212197A1 (enExample) |
| PH (1) | PH12021551495A1 (enExample) |
| SG (1) | SG11202106526UA (enExample) |
| TW (1) | TWI875727B (enExample) |
| UA (1) | UA130491C2 (enExample) |
| WO (1) | WO2020132471A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20211462T1 (hr) | 2017-04-24 | 2021-12-24 | Aurigene Discovery Technologies Limited | Postupci uporabe za trisupstituirane derivate benzotriazola kao inhibitora dihidroorotatne oksigenaze |
| TWI818954B (zh) | 2018-02-20 | 2023-10-21 | 法商施維雅藥廠 | 三取代之苯并三唑衍生物的使用方法 |
| ES3063941T3 (en) * | 2020-08-27 | 2026-04-21 | Servier Lab | Combinations of a dhodh inhibitor and r-chop therapy for the treatment of diffuse large b-cell lymphoma, mantle cell lymphoma and burkitt lymphoma |
| WO2025227007A1 (en) * | 2024-04-26 | 2025-10-30 | Ohio State Innovation Foundation | Methods and compositions for inhibition of dihydroorotate dehydrogenase |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103476770A (zh) * | 2010-11-25 | 2013-12-25 | 拉蒂欧制药有限责任公司 | 新的阿法替尼盐和多晶型物 |
| WO2014128669A2 (en) * | 2013-02-25 | 2014-08-28 | Aurigene Discovery Technologies Limited | Trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors |
| WO2018197997A1 (en) * | 2017-04-24 | 2018-11-01 | Aurigene Discovery Technologies Limited | Methods of use for trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001024785A2 (en) | 1999-10-01 | 2001-04-12 | Institute Of Molecular And Cell Biology | Dihydroorotate dehydrogenase inhibitors for the treatment of viral-mediated diseases |
| JP2007015952A (ja) | 2005-07-06 | 2007-01-25 | Shionogi & Co Ltd | ナフタレン誘導体 |
| EP2276763A1 (en) | 2008-03-19 | 2011-01-26 | OSI Pharmaceuticals, Inc. | Mtor inhibitor salt forms |
| EP2230232A1 (en) | 2009-03-13 | 2010-09-22 | Almirall, S.A. | Addition salts of tromethamine with azabiphenylaminobenzoic acid derivatives as DHODH inhibitors |
| EP2228367A1 (en) * | 2009-03-13 | 2010-09-15 | Almirall, S.A. | Addition salts of amines containing hydroxyl and/or carboxylic groups with amino nicotinic acid derivatives as DHODH inhibitors |
| TW201733984A (zh) | 2011-04-13 | 2017-10-01 | 雅酶股份有限公司 | 經取代之苯化合物 |
| US9360932B1 (en) | 2012-08-29 | 2016-06-07 | Intellect Motion Llc. | Systems and methods for virtually displaying real movements of objects in a 3D-space by means of 2D-video capture |
| CN103965133B (zh) * | 2013-01-31 | 2018-11-30 | 华东理工大学 | 一种具有dhodh抑制活性的含n、s杂环化合物及其制备和用途 |
| JP6961879B2 (ja) | 2015-12-30 | 2021-11-05 | レ ラボラトワール セルヴィエ ソシエテ・パール・アクシオンス・サンプリフィエ | 変異体イソクエン酸デヒドロゲナーゼを包含する腫瘍の処置 |
| JOP20190094A1 (ar) | 2016-10-27 | 2019-04-25 | Broad Inst Inc | مركبات 1، 2، 4-تريازولون تحمل ثلاثة بدائل عند المواقع 2، 4، 5 مفيدة كمثبطات لديهيدروجيناز ثنائي هيدرو أوروتات (dhodh) |
| TWI818954B (zh) * | 2018-02-20 | 2023-10-21 | 法商施維雅藥廠 | 三取代之苯并三唑衍生物的使用方法 |
| CA3184024A1 (en) * | 2020-06-24 | 2021-12-30 | Les Laboratoires Servier | Use of a dhodh inhibitor compound in combination cancer therapy |
| ES3063941T3 (en) * | 2020-08-27 | 2026-04-21 | Servier Lab | Combinations of a dhodh inhibitor and r-chop therapy for the treatment of diffuse large b-cell lymphoma, mantle cell lymphoma and burkitt lymphoma |
-
2019
- 2019-12-20 JO JOP/2021/0147A patent/JOP20210147A1/ar unknown
- 2019-12-20 US US17/416,910 patent/US12297179B2/en active Active
- 2019-12-20 UA UAA202104251A patent/UA130491C2/uk unknown
- 2019-12-20 AU AU2019403396A patent/AU2019403396B2/en active Active
- 2019-12-20 PE PE2021001052A patent/PE20212197A1/es unknown
- 2019-12-20 EP EP19839747.3A patent/EP3898597A1/en active Pending
- 2019-12-20 GE GEAP202415700A patent/GEAP202415700A/en unknown
- 2019-12-20 CN CN201980091991.XA patent/CN113508108B/zh active Active
- 2019-12-20 WO PCT/US2019/067897 patent/WO2020132471A1/en not_active Ceased
- 2019-12-20 TW TW108147117A patent/TWI875727B/zh active
- 2019-12-20 KR KR1020217022945A patent/KR20220035022A/ko not_active Ceased
- 2019-12-20 GE GEAP201915700A patent/GEP20247683B/en unknown
- 2019-12-20 BR BR112021012305-9A patent/BR112021012305A2/pt unknown
- 2019-12-20 PE PE2025003120A patent/PE20260309A1/es unknown
- 2019-12-20 CR CR20210394A patent/CR20210394A/es unknown
- 2019-12-20 JP JP2021536323A patent/JP2022515239A/ja active Pending
- 2019-12-20 MA MA054541A patent/MA54541A/fr unknown
- 2019-12-20 MX MX2021007536A patent/MX2021007536A/es unknown
- 2019-12-20 CA CA3124401A patent/CA3124401A1/en active Pending
- 2019-12-20 SG SG11202106526UA patent/SG11202106526UA/en unknown
-
2020
- 2020-01-09 PH PH1/2021/551495A patent/PH12021551495A1/en unknown
-
2021
- 2021-06-18 CL CL2021001640A patent/CL2021001640A1/es unknown
- 2021-06-20 IL IL284218A patent/IL284218B1/en unknown
- 2021-06-21 NI NI202100055A patent/NI202100055A/es unknown
- 2021-07-15 CO CONC2021/0009309A patent/CO2021009309A2/es unknown
-
2024
- 2024-08-07 JP JP2024131002A patent/JP7749080B2/ja active Active
-
2025
- 2025-05-07 US US19/201,581 patent/US20250270175A1/en active Pending
- 2025-09-22 JP JP2025156833A patent/JP2026001058A/ja active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103476770A (zh) * | 2010-11-25 | 2013-12-25 | 拉蒂欧制药有限责任公司 | 新的阿法替尼盐和多晶型物 |
| WO2014128669A2 (en) * | 2013-02-25 | 2014-08-28 | Aurigene Discovery Technologies Limited | Trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors |
| WO2018197997A1 (en) * | 2017-04-24 | 2018-11-01 | Aurigene Discovery Technologies Limited | Methods of use for trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors |
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