KR20220035022A - 유기 화합물의 결정질 및 염 형태 및 그의 제약 조성물 - Google Patents

유기 화합물의 결정질 및 염 형태 및 그의 제약 조성물 Download PDF

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Publication number
KR20220035022A
KR20220035022A KR1020217022945A KR20217022945A KR20220035022A KR 20220035022 A KR20220035022 A KR 20220035022A KR 1020217022945 A KR1020217022945 A KR 1020217022945A KR 20217022945 A KR20217022945 A KR 20217022945A KR 20220035022 A KR20220035022 A KR 20220035022A
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South Korea
Prior art keywords
crystalline form
cancer
pharmaceutical composition
compound
tris
Prior art date
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Ceased
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KR1020217022945A
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English (en)
Korean (ko)
Inventor
시예드 알타프
아비라 라마크리시난
제이콥 시즈모어
시지에 장
Original Assignee
르 라보레또레 쎄르비에르
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Publication of KR20220035022A publication Critical patent/KR20220035022A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020217022945A 2018-12-21 2019-12-20 유기 화합물의 결정질 및 염 형태 및 그의 제약 조성물 Ceased KR20220035022A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862784083P 2018-12-21 2018-12-21
US62/784,083 2018-12-21
US201962791571P 2019-01-11 2019-01-11
US62/791,571 2019-01-11
US201962882712P 2019-08-05 2019-08-05
US62/882,712 2019-08-05
PCT/US2019/067897 WO2020132471A1 (en) 2018-12-21 2019-12-20 Crystalline and salt forms of an organic compound and pharmaceutical compositions thereof

Publications (1)

Publication Number Publication Date
KR20220035022A true KR20220035022A (ko) 2022-03-21

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KR1020217022945A Ceased KR20220035022A (ko) 2018-12-21 2019-12-20 유기 화합물의 결정질 및 염 형태 및 그의 제약 조성물

Country Status (23)

Country Link
US (2) US12297179B2 (enExample)
EP (1) EP3898597A1 (enExample)
JP (3) JP2022515239A (enExample)
KR (1) KR20220035022A (enExample)
CN (1) CN113508108B (enExample)
AU (1) AU2019403396B2 (enExample)
BR (1) BR112021012305A2 (enExample)
CA (1) CA3124401A1 (enExample)
CL (1) CL2021001640A1 (enExample)
CO (1) CO2021009309A2 (enExample)
CR (1) CR20210394A (enExample)
GE (2) GEAP202415700A (enExample)
IL (1) IL284218B1 (enExample)
JO (1) JOP20210147A1 (enExample)
MA (1) MA54541A (enExample)
MX (1) MX2021007536A (enExample)
NI (1) NI202100055A (enExample)
PE (2) PE20212197A1 (enExample)
PH (1) PH12021551495A1 (enExample)
SG (1) SG11202106526UA (enExample)
TW (1) TWI875727B (enExample)
UA (1) UA130491C2 (enExample)
WO (1) WO2020132471A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20211462T1 (hr) 2017-04-24 2021-12-24 Aurigene Discovery Technologies Limited Postupci uporabe za trisupstituirane derivate benzotriazola kao inhibitora dihidroorotatne oksigenaze
TWI818954B (zh) 2018-02-20 2023-10-21 法商施維雅藥廠 三取代之苯并三唑衍生物的使用方法
ES3063941T3 (en) * 2020-08-27 2026-04-21 Servier Lab Combinations of a dhodh inhibitor and r-chop therapy for the treatment of diffuse large b-cell lymphoma, mantle cell lymphoma and burkitt lymphoma
WO2025227007A1 (en) * 2024-04-26 2025-10-30 Ohio State Innovation Foundation Methods and compositions for inhibition of dihydroorotate dehydrogenase

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001024785A2 (en) 1999-10-01 2001-04-12 Institute Of Molecular And Cell Biology Dihydroorotate dehydrogenase inhibitors for the treatment of viral-mediated diseases
JP2007015952A (ja) 2005-07-06 2007-01-25 Shionogi & Co Ltd ナフタレン誘導体
EP2276763A1 (en) 2008-03-19 2011-01-26 OSI Pharmaceuticals, Inc. Mtor inhibitor salt forms
EP2230232A1 (en) 2009-03-13 2010-09-22 Almirall, S.A. Addition salts of tromethamine with azabiphenylaminobenzoic acid derivatives as DHODH inhibitors
EP2228367A1 (en) * 2009-03-13 2010-09-15 Almirall, S.A. Addition salts of amines containing hydroxyl and/or carboxylic groups with amino nicotinic acid derivatives as DHODH inhibitors
US9012464B2 (en) * 2010-11-25 2015-04-21 Ratiopharm Gmbh Salts and polymorphic forms of Afatinib
TW201733984A (zh) 2011-04-13 2017-10-01 雅酶股份有限公司 經取代之苯化合物
US9360932B1 (en) 2012-08-29 2016-06-07 Intellect Motion Llc. Systems and methods for virtually displaying real movements of objects in a 3D-space by means of 2D-video capture
CN103965133B (zh) * 2013-01-31 2018-11-30 华东理工大学 一种具有dhodh抑制活性的含n、s杂环化合物及其制备和用途
RS57962B1 (sr) 2013-02-25 2019-01-31 Aurigene Discovery Tech Ltd Derivati trisupstituisanog benzotriazola kao inhibitori dihidroorotat oksigenaze
JP6961879B2 (ja) 2015-12-30 2021-11-05 レ ラボラトワール セルヴィエ ソシエテ・パール・アクシオンス・サンプリフィエ 変異体イソクエン酸デヒドロゲナーゼを包含する腫瘍の処置
JOP20190094A1 (ar) 2016-10-27 2019-04-25 Broad Inst Inc مركبات 1، 2، 4-تريازولون تحمل ثلاثة بدائل عند المواقع 2، 4، 5 مفيدة كمثبطات لديهيدروجيناز ثنائي هيدرو أوروتات (dhodh)
US20180369206A1 (en) 2017-04-24 2018-12-27 Aurigene Discovery Technologies Limited Methods of Use for Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors
TWI818954B (zh) * 2018-02-20 2023-10-21 法商施維雅藥廠 三取代之苯并三唑衍生物的使用方法
CA3184024A1 (en) * 2020-06-24 2021-12-30 Les Laboratoires Servier Use of a dhodh inhibitor compound in combination cancer therapy
ES3063941T3 (en) * 2020-08-27 2026-04-21 Servier Lab Combinations of a dhodh inhibitor and r-chop therapy for the treatment of diffuse large b-cell lymphoma, mantle cell lymphoma and burkitt lymphoma

Also Published As

Publication number Publication date
NI202100055A (es) 2021-12-01
MX2021007536A (es) 2021-09-23
BR112021012305A2 (pt) 2021-10-05
GEAP202415700A (en) 2024-05-13
JP7749080B2 (ja) 2025-10-03
TWI875727B (zh) 2025-03-11
CA3124401A1 (en) 2020-06-25
CN113508108B (zh) 2024-12-24
AU2019403396A1 (en) 2021-07-08
CL2021001640A1 (es) 2022-06-03
CN113508108A (zh) 2021-10-15
JOP20210147A1 (ar) 2023-01-30
US12297179B2 (en) 2025-05-13
IL284218A (en) 2021-08-31
WO2020132471A1 (en) 2020-06-25
US20250270175A1 (en) 2025-08-28
PH12021551495A1 (en) 2022-03-07
JP2026001058A (ja) 2026-01-06
SG11202106526UA (en) 2021-07-29
UA130491C2 (uk) 2026-03-04
CO2021009309A2 (es) 2021-10-29
WO2020132471A8 (en) 2020-08-06
PE20212197A1 (es) 2021-11-16
PE20260309A1 (es) 2026-02-11
AU2019403396B2 (en) 2024-12-12
GEP20247683B (en) 2024-10-28
EP3898597A1 (en) 2021-10-27
MA54541A (fr) 2022-03-09
JP2024161431A (ja) 2024-11-19
US20220055995A1 (en) 2022-02-24
TW202039448A (zh) 2020-11-01
JP2022515239A (ja) 2022-02-17
IL284218B1 (en) 2026-01-01
CR20210394A (es) 2021-12-13

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