TWI874337B - 神經活性類固醇及其使用方法 - Google Patents

神經活性類固醇及其使用方法 Download PDF

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Publication number
TWI874337B
TWI874337B TW108144589A TW108144589A TWI874337B TW I874337 B TWI874337 B TW I874337B TW 108144589 A TW108144589 A TW 108144589A TW 108144589 A TW108144589 A TW 108144589A TW I874337 B TWI874337 B TW I874337B
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Taiwan
Prior art keywords
compound
substituted
unsubstituted
group
pharmaceutically acceptable
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TW108144589A
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English (en)
Chinese (zh)
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TW202039528A (zh
Inventor
佩拉杜 馬利亞 耶稣 巴蘭可
法藍西司科 G 薩突羅
馬歇爾 理 莫寧斯塔爾
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美商賽吉醫療公司
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Publication of TW202039528A publication Critical patent/TW202039528A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0044—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an estrane or gonane skeleton, including 18-substituted derivatives and derivatives where position 17-beta is substituted by a carbon atom not directly bonded to another carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW108144589A 2018-12-05 2019-12-05 神經活性類固醇及其使用方法 TWI874337B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862775470P 2018-12-05 2018-12-05
US62/775,470 2018-12-05

Publications (2)

Publication Number Publication Date
TW202039528A TW202039528A (zh) 2020-11-01
TWI874337B true TWI874337B (zh) 2025-03-01

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
TW108144589A TWI874337B (zh) 2018-12-05 2019-12-05 神經活性類固醇及其使用方法
TW114104450A TW202521127A (zh) 2018-12-05 2019-12-05 神經活性類固醇及其使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
TW114104450A TW202521127A (zh) 2018-12-05 2019-12-05 神經活性類固醇及其使用方法

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Country Link
US (8) US20230322846A9 (enExample)
EP (1) EP3902818A1 (enExample)
JP (3) JP7539378B2 (enExample)
KR (2) KR20250174100A (enExample)
CN (1) CN113383004A (enExample)
AR (1) AR117264A1 (enExample)
AU (3) AU2019392680B2 (enExample)
BR (1) BR112021010996A2 (enExample)
CA (1) CA3120872A1 (enExample)
IL (3) IL312610B1 (enExample)
MA (1) MA54594A (enExample)
MX (4) MX2021006618A (enExample)
TW (2) TWI874337B (enExample)
WO (1) WO2020118060A1 (enExample)

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US10246482B2 (en) 2014-06-18 2019-04-02 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
JOP20200195A1 (ar) 2014-09-08 2017-06-16 Sage Therapeutics Inc سترويدات وتركيبات نشطة عصبياً، واستخداماتها
WO2016082789A1 (en) 2014-11-27 2016-06-02 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
EP3504189A1 (en) 2016-08-23 2019-07-03 Sage Therapeutics, Inc. A crystalline 19-nor c3, 3-disubstituted c21-n-pyrazolyl steroid
MA51046A (fr) 2017-12-08 2021-03-17 Sage Therapeutics Inc Dérivés de 21-[4-cyano-pyrazol-1-yl]-19-nor-pregan-3. alpha-ol-20-one deutérés pour le traitement de troubles du snc
MX2020006599A (es) * 2017-12-22 2020-11-06 Sage Therapeutics Inc Composiciones y metodos para el tratamiento de trastornos en el sistema nervioso central.
TW201930269A (zh) 2018-01-12 2019-08-01 美商賽吉醫療公司 用於治療cns病症之組合物及方法
WO2020132504A1 (en) * 2018-12-21 2020-06-25 Sage Therapeutics, Inc. 3.alpha.-hydroxy-17.beta.-amide neuroactive steroids and compositions thereof
SG11202112391UA (en) 2019-05-31 2021-12-30 Sage Therapeutics Inc Neuroactive steroids and compositions thereof
CN114729000A (zh) * 2019-06-27 2022-07-08 萨奇治疗股份有限公司 用于治疗cns病症的化合物
CA3143509A1 (en) * 2019-06-27 2020-12-30 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
WO2021188778A2 (en) * 2020-03-18 2021-09-23 Sage Therapeutics, Inc. Neuroactive steroids and their methods of use
CN112679571A (zh) * 2020-12-24 2021-04-20 广西壮族自治区中国科学院广西植物研究所 一种罗汉果醇衍生物单体、其制备方法及应用
JP2024532273A (ja) * 2021-08-25 2024-09-05 セージ セラピューティクス， インコーポレイテッド ポジティブｎｍｄａモジュレート化合物及びその使用方法
CN115974950A (zh) * 2022-12-23 2023-04-18 上海彩迩文生化科技有限公司 一种3-烷基化的甾体中间体及其制备和应用
JP2026509303A (ja) 2023-03-14 2026-03-17 キュリア、スペイン、エセ、ア、ウ ３アルファ－ヒドロキシ－３ベータ－アルキルステロイドを調製するための方法および中間体
WO2024197317A2 (en) * 2023-03-23 2024-09-26 Emory University Neurosteroids and prodrugs thereof
CN119529013B (zh) * 2024-11-25 2025-11-07 湖南新合新生物医药有限公司 一种祖拉诺龙中间体的合成方法

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IL283629B2 (en) 2026-03-01
US20240309042A1 (en) 2024-09-19
AU2019392680B2 (en) 2025-07-10
US11970514B2 (en) 2024-04-30
JP2024105504A (ja) 2024-08-06
AU2025203487A1 (en) 2025-05-29
JP2022510683A (ja) 2022-01-27
TW202521129A (zh) 2025-06-01
KR20250174100A (ko) 2025-12-11
MX2021006618A (es) 2021-09-23
US11999765B2 (en) 2024-06-04
US11912738B2 (en) 2024-02-27
IL312611A (en) 2024-07-01
KR102892974B1 (ko) 2025-11-28
US20240343756A1 (en) 2024-10-17
WO2020118060A1 (en) 2020-06-11
BR112021010996A2 (pt) 2021-08-31
MX2024004789A (es) 2024-05-09
US20230322849A1 (en) 2023-10-12
US20250154194A1 (en) 2025-05-15
JP7539378B2 (ja) 2024-08-23
US20230322847A1 (en) 2023-10-12
US20230322846A9 (en) 2023-10-12
CA3120872A1 (en) 2020-06-11
AU2019392680A1 (en) 2021-06-10
TW202039528A (zh) 2020-11-01
US12410210B2 (en) 2025-09-09
JP2025134803A (ja) 2025-09-17
IL312610A (en) 2024-07-01
KR20210112318A (ko) 2021-09-14
MA54594A (fr) 2022-04-06
US20230046825A1 (en) 2023-02-16
JP7720948B2 (ja) 2025-08-08
IL312611B1 (en) 2025-05-01
IL283629B1 (en) 2025-11-01
IL312611B2 (en) 2025-09-01
MX2024004788A (es) 2024-05-09
US20230322848A1 (en) 2023-10-12
EP3902818A1 (en) 2021-11-03
MX2024004790A (es) 2024-05-09
IL283629A (en) 2021-07-29
AU2025203485A1 (en) 2025-05-29
CN113383004A (zh) 2021-09-10
US20240336648A1 (en) 2024-10-10
AR117264A1 (es) 2021-07-21
US12252509B2 (en) 2025-03-18
US12264177B2 (en) 2025-04-01
IL312610B1 (en) 2026-01-01
TW202521127A (zh) 2025-06-01

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