AU2019392680B2 - Neuroactive steroids and their methods of use - Google Patents

Neuroactive steroids and their methods of use Download PDF

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Publication number
AU2019392680B2
AU2019392680B2 AU2019392680A AU2019392680A AU2019392680B2 AU 2019392680 B2 AU2019392680 B2 AU 2019392680B2 AU 2019392680 A AU2019392680 A AU 2019392680A AU 2019392680 A AU2019392680 A AU 2019392680A AU 2019392680 B2 AU2019392680 B2 AU 2019392680B2
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AU
Australia
Prior art keywords
methods
neuroactive steroids
neuroactive
steroids
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2019392680A
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English (en)
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AU2019392680A1 (en
Inventor
Maria Jesus Blanco-Pillado
Marshall Lee Morningstar
Francesco G. Salituro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sage Therapeutics LLC
Original Assignee
Sage Therapeutics LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sage Therapeutics LLC filed Critical Sage Therapeutics LLC
Publication of AU2019392680A1 publication Critical patent/AU2019392680A1/en
Priority to AU2025203487A priority Critical patent/AU2025203487A1/en
Priority to AU2025203485A priority patent/AU2025203485A1/en
Application granted granted Critical
Publication of AU2019392680B2 publication Critical patent/AU2019392680B2/en
Assigned to Sage Therapeutics, LLC reassignment Sage Therapeutics, LLC Request to Amend Deed and Register Assignors: SAGE THERAPEUTICS, INC.
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0044—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an estrane or gonane skeleton, including 18-substituted derivatives and derivatives where position 17-beta is substituted by a carbon atom not directly bonded to another carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2019392680A 2018-12-05 2019-12-05 Neuroactive steroids and their methods of use Active AU2019392680B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2025203487A AU2025203487A1 (en) 2018-12-05 2025-05-14 Neuroactive steroids and their methods of use
AU2025203485A AU2025203485A1 (en) 2018-12-05 2025-05-14 Neuroactive steroids and their methods of use

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862775470P 2018-12-05 2018-12-05
US62/775,470 2018-12-05
PCT/US2019/064692 WO2020118060A1 (en) 2018-12-05 2019-12-05 Neuroactive steroids and their methods of use

Related Child Applications (2)

Application Number Title Priority Date Filing Date
AU2025203487A Division AU2025203487A1 (en) 2018-12-05 2025-05-14 Neuroactive steroids and their methods of use
AU2025203485A Division AU2025203485A1 (en) 2018-12-05 2025-05-14 Neuroactive steroids and their methods of use

Publications (2)

Publication Number Publication Date
AU2019392680A1 AU2019392680A1 (en) 2021-06-10
AU2019392680B2 true AU2019392680B2 (en) 2025-07-10

Family

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Family Applications (3)

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AU2019392680A Active AU2019392680B2 (en) 2018-12-05 2019-12-05 Neuroactive steroids and their methods of use
AU2025203487A Pending AU2025203487A1 (en) 2018-12-05 2025-05-14 Neuroactive steroids and their methods of use
AU2025203485A Pending AU2025203485A1 (en) 2018-12-05 2025-05-14 Neuroactive steroids and their methods of use

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AU2025203487A Pending AU2025203487A1 (en) 2018-12-05 2025-05-14 Neuroactive steroids and their methods of use
AU2025203485A Pending AU2025203485A1 (en) 2018-12-05 2025-05-14 Neuroactive steroids and their methods of use

Country Status (14)

Country Link
US (8) US20230322846A9 (enExample)
EP (1) EP3902818A1 (enExample)
JP (3) JP7539378B2 (enExample)
KR (2) KR20250174100A (enExample)
CN (1) CN113383004A (enExample)
AR (1) AR117264A1 (enExample)
AU (3) AU2019392680B2 (enExample)
BR (1) BR112021010996A2 (enExample)
CA (1) CA3120872A1 (enExample)
IL (3) IL312610B1 (enExample)
MA (1) MA54594A (enExample)
MX (4) MX2021006618A (enExample)
TW (2) TWI874337B (enExample)
WO (1) WO2020118060A1 (enExample)

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EP2806877B2 (en) 2012-01-23 2025-01-29 Sage Therapeutics, Inc. Neuroactive steroid formulations comprising a complex of allopregnanolone and sulfobutyl ether beta-cyclodextrin
CA2882708A1 (en) 2012-08-21 2014-02-27 Sage Therapeutics, Inc. Methods of treating epilepsy or status epilepticus
KR102396328B1 (ko) 2013-04-17 2022-05-10 세이지 테라퓨틱스, 인크. 19-노르 c3,3-이치환된 c21-n-피라졸릴 스테로이드 및 그의 사용 방법
US10246482B2 (en) 2014-06-18 2019-04-02 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
JOP20200195A1 (ar) 2014-09-08 2017-06-16 Sage Therapeutics Inc سترويدات وتركيبات نشطة عصبياً، واستخداماتها
WO2016082789A1 (en) 2014-11-27 2016-06-02 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
EP3504189A1 (en) 2016-08-23 2019-07-03 Sage Therapeutics, Inc. A crystalline 19-nor c3, 3-disubstituted c21-n-pyrazolyl steroid
MA51046A (fr) 2017-12-08 2021-03-17 Sage Therapeutics Inc Dérivés de 21-[4-cyano-pyrazol-1-yl]-19-nor-pregan-3. alpha-ol-20-one deutérés pour le traitement de troubles du snc
MX2020006599A (es) * 2017-12-22 2020-11-06 Sage Therapeutics Inc Composiciones y metodos para el tratamiento de trastornos en el sistema nervioso central.
TW201930269A (zh) 2018-01-12 2019-08-01 美商賽吉醫療公司 用於治療cns病症之組合物及方法
WO2020132504A1 (en) * 2018-12-21 2020-06-25 Sage Therapeutics, Inc. 3.alpha.-hydroxy-17.beta.-amide neuroactive steroids and compositions thereof
SG11202112391UA (en) 2019-05-31 2021-12-30 Sage Therapeutics Inc Neuroactive steroids and compositions thereof
CN114729000A (zh) * 2019-06-27 2022-07-08 萨奇治疗股份有限公司 用于治疗cns病症的化合物
CA3143509A1 (en) * 2019-06-27 2020-12-30 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
WO2021188778A2 (en) * 2020-03-18 2021-09-23 Sage Therapeutics, Inc. Neuroactive steroids and their methods of use
CN112679571A (zh) * 2020-12-24 2021-04-20 广西壮族自治区中国科学院广西植物研究所 一种罗汉果醇衍生物单体、其制备方法及应用
JP2024532273A (ja) * 2021-08-25 2024-09-05 セージ セラピューティクス， インコーポレイテッド ポジティブｎｍｄａモジュレート化合物及びその使用方法
CN115974950A (zh) * 2022-12-23 2023-04-18 上海彩迩文生化科技有限公司 一种3-烷基化的甾体中间体及其制备和应用
JP2026509303A (ja) 2023-03-14 2026-03-17 キュリア、スペイン、エセ、ア、ウ ３アルファ－ヒドロキシ－３ベータ－アルキルステロイドを調製するための方法および中間体
WO2024197317A2 (en) * 2023-03-23 2024-09-26 Emory University Neurosteroids and prodrugs thereof
CN119529013B (zh) * 2024-11-25 2025-11-07 湖南新合新生物医药有限公司 一种祖拉诺龙中间体的合成方法

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WO2017049044A1 (en) * 2015-09-16 2017-03-23 Bartolucci Giampiero Ursodeoxycholic acid and brain disorders

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WO1996016076A1 (en) * 1994-11-23 1996-05-30 Cocensys, Inc. Androstane and pregnane series for allosteric modulation of gaba receptor
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WO2017049044A1 (en) * 2015-09-16 2017-03-23 Bartolucci Giampiero Ursodeoxycholic acid and brain disorders

Also Published As

Publication number Publication date
IL283629B2 (en) 2026-03-01
US20240309042A1 (en) 2024-09-19
US11970514B2 (en) 2024-04-30
JP2024105504A (ja) 2024-08-06
AU2025203487A1 (en) 2025-05-29
JP2022510683A (ja) 2022-01-27
TW202521129A (zh) 2025-06-01
KR20250174100A (ko) 2025-12-11
MX2021006618A (es) 2021-09-23
US11999765B2 (en) 2024-06-04
US11912738B2 (en) 2024-02-27
IL312611A (en) 2024-07-01
KR102892974B1 (ko) 2025-11-28
US20240343756A1 (en) 2024-10-17
WO2020118060A1 (en) 2020-06-11
BR112021010996A2 (pt) 2021-08-31
MX2024004789A (es) 2024-05-09
US20230322849A1 (en) 2023-10-12
US20250154194A1 (en) 2025-05-15
JP7539378B2 (ja) 2024-08-23
US20230322847A1 (en) 2023-10-12
US20230322846A9 (en) 2023-10-12
CA3120872A1 (en) 2020-06-11
AU2019392680A1 (en) 2021-06-10
TW202039528A (zh) 2020-11-01
US12410210B2 (en) 2025-09-09
JP2025134803A (ja) 2025-09-17
IL312610A (en) 2024-07-01
KR20210112318A (ko) 2021-09-14
MA54594A (fr) 2022-04-06
US20230046825A1 (en) 2023-02-16
JP7720948B2 (ja) 2025-08-08
IL312611B1 (en) 2025-05-01
IL283629B1 (en) 2025-11-01
TWI874337B (zh) 2025-03-01
IL312611B2 (en) 2025-09-01
MX2024004788A (es) 2024-05-09
US20230322848A1 (en) 2023-10-12
EP3902818A1 (en) 2021-11-03
MX2024004790A (es) 2024-05-09
IL283629A (en) 2021-07-29
AU2025203485A1 (en) 2025-05-29
CN113383004A (zh) 2021-09-10
US20240336648A1 (en) 2024-10-10
AR117264A1 (es) 2021-07-21
US12252509B2 (en) 2025-03-18
US12264177B2 (en) 2025-04-01
IL312610B1 (en) 2026-01-01
TW202521127A (zh) 2025-06-01

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