TWI865451B - 單特異性及多特異性抗ｔｍｅｆｆ２抗體及其用途 - Google Patents

單特異性及多特異性抗ｔｍｅｆｆ２抗體及其用途 Download PDF

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TWI865451B
TWI865451B TW108117613A TW108117613A TWI865451B TW I865451 B TWI865451 B TW I865451B TW 108117613 A TW108117613 A TW 108117613A TW 108117613 A TW108117613 A TW 108117613A TW I865451 B TWI865451 B TW I865451B
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Taiwan
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seq
antibody
tmeff2
antigen
binding fragment
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TW108117613A
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Chinese (zh)
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TW202003584A (zh
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飛利浦 古柏
羅賓 恩斯特
拉庫瑪 甘尼申
柯林 凱恩
麥可 羅素
桑加亞 辛格
莎菲亞迪維 維加塔拉瑪尼
勝君 吳
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美商健生生物科技公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW108117613A 2018-05-24 2019-05-22 單特異性及多特異性抗ｔｍｅｆｆ２抗體及其用途 TWI865451B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862675957P 2018-05-24 2018-05-24
US62/675,957 2018-05-24

Publications (2)

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TW202003584A TW202003584A (zh) 2020-01-16
TWI865451B true TWI865451B (zh) 2024-12-11

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Country Status (25)

Country Link
US (1) US11866499B2 (https=)
EP (1) EP3802607A2 (https=)
JP (2) JP2021524255A (https=)
KR (1) KR20210011999A (https=)
CN (1) CN112703203B (https=)
AR (1) AR115419A1 (https=)
AU (1) AU2019274652B2 (https=)
BR (1) BR112020023416A2 (https=)
CA (1) CA3101304A1 (https=)
CL (1) CL2020003032A1 (https=)
CO (1) CO2020014515A2 (https=)
CR (1) CR20200564A (https=)
EA (1) EA202092849A1 (https=)
EC (1) ECSP20075234A (https=)
IL (1) IL278862A (https=)
JO (1) JOP20200295A1 (https=)
MA (1) MA52772A (https=)
MX (1) MX2020012589A (https=)
NI (1) NI202000087A (https=)
PE (1) PE20210634A1 (https=)
PH (1) PH12020551948A1 (https=)
SG (1) SG11202011268VA (https=)
TW (1) TWI865451B (https=)
UY (1) UY38243A (https=)
WO (1) WO2019224713A2 (https=)

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US11603405B2 (en) 2018-05-24 2023-03-14 Janssen Biotech, Inc. Anti-CD3 antibodies and uses thereof
CA3164972A1 (en) * 2019-12-18 2021-06-24 Janssen Biotech, Inc. Materials and methods for in vivo biological targeting
CN116249714A (zh) 2020-05-27 2023-06-09 詹森生物科技公司 包含cd3抗原结合结构域的蛋白质及其用途
US20230374140A1 (en) * 2020-10-09 2023-11-23 Memorial Sloan Kettering Cancer Center Compositions targeting ndc80/mhc complexes and uses thereof
TW202231292A (zh) 2020-10-13 2022-08-16 美商健生生物科技公司 用於調節分化簇ｉｖ及／或ｖｉｉｉ的經生物工程改造之ｔ細胞介導之免疫力、材料、及其他方法
CN119110809A (zh) 2022-02-23 2024-12-10 Xencor股份有限公司 抗CD28 x抗PSMA抗体
CA3266816A1 (en) * 2022-09-09 2024-03-14 Janssen Biotech, Inc. CANCER TREATMENT METHOD WITH AN ANTI-TMEFF2XCD3 BISPECIFIC ANTIBODY

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JP2021524255A (ja) 2021-09-13
KR20210011999A (ko) 2021-02-02
US11866499B2 (en) 2024-01-09
CR20200564A (es) 2021-06-21
JOP20200295A1 (ar) 2020-11-22
WO2019224713A2 (en) 2019-11-28
EP3802607A2 (en) 2021-04-14
US20190359711A1 (en) 2019-11-28
AR115419A1 (es) 2021-01-13
BR112020023416A2 (pt) 2021-02-17
UY38243A (es) 2019-11-29
JP2024105476A (ja) 2024-08-06
TW202003584A (zh) 2020-01-16
ECSP20075234A (es) 2020-12-31
CN112703203A (zh) 2021-04-23
WO2019224713A3 (en) 2020-01-02
PH12020551948A1 (en) 2021-08-16
CA3101304A1 (en) 2019-11-28
AU2019274652B2 (en) 2026-03-26
CL2020003032A1 (es) 2021-04-16
EA202092849A1 (ru) 2021-03-16
NI202000087A (es) 2021-03-23
MX2020012589A (es) 2021-01-29
CO2020014515A2 (es) 2020-12-10
MA52772A (fr) 2021-04-14
IL278862A (en) 2021-01-31
PE20210634A1 (es) 2021-03-23
AU2019274652A1 (en) 2020-11-26
CN112703203B (zh) 2025-02-25
SG11202011268VA (en) 2020-12-30

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