TWI848171B - 含有迪夸弗索(diquafosol)或其鹽、及聚乙烯吡咯烷酮之水性眼科用組合物 - Google Patents

含有迪夸弗索(diquafosol)或其鹽、及聚乙烯吡咯烷酮之水性眼科用組合物 Download PDF

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Publication number
TWI848171B
TWI848171B TW109128895A TW109128895A TWI848171B TW I848171 B TWI848171 B TW I848171B TW 109128895 A TW109128895 A TW 109128895A TW 109128895 A TW109128895 A TW 109128895A TW I848171 B TWI848171 B TW I848171B
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TW
Taiwan
Prior art keywords
ophthalmic composition
aqueous ophthalmic
eye
day
sodium
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TW109128895A
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English (en)
Chinese (zh)
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TW202122094A (zh
Inventor
森島健司
浅田博之
桃川雄介
神村明日香
遠藤健一
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日商參天製藥股份有限公司
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Publication of TW202122094A publication Critical patent/TW202122094A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
TW109128895A 2019-08-27 2020-08-25 含有迪夸弗索(diquafosol)或其鹽、及聚乙烯吡咯烷酮之水性眼科用組合物 TWI848171B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2019-154525 2019-08-27
JP2019154525 2019-08-27

Publications (2)

Publication Number Publication Date
TW202122094A TW202122094A (zh) 2021-06-16
TWI848171B true TWI848171B (zh) 2024-07-11

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Family Applications (1)

Application Number Title Priority Date Filing Date
TW109128895A TWI848171B (zh) 2019-08-27 2020-08-25 含有迪夸弗索(diquafosol)或其鹽、及聚乙烯吡咯烷酮之水性眼科用組合物

Country Status (7)

Country Link
JP (3) JP6966667B2 (enExample)
KR (2) KR20240049646A (enExample)
CN (2) CN117771172A (enExample)
MY (1) MY209059A (enExample)
PH (1) PH12022550474A1 (enExample)
TW (1) TWI848171B (enExample)
WO (1) WO2021039748A1 (enExample)

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Publication number Priority date Publication date Assignee Title
TWI833406B (zh) * 2018-02-28 2024-02-21 日商參天製藥股份有限公司 含有迪夸弗索（Ｄｉｑｕａｆｏｓｏｌ）及陽離子性聚合物之眼科用組合物
JP7175431B1 (ja) * 2021-03-30 2022-11-18 千寿製薬株式会社 ヘテロシクリデンアセトアミド誘導体含有懸濁液
CN114646705A (zh) * 2022-03-22 2022-06-21 武汉绿合医药科技有限公司 一种地夸磷索钠滴眼液有关物质含量检测方法
JP7245383B1 (ja) 2022-09-20 2023-03-23 参天製薬株式会社 ジクアホソルまたはその塩を含有する眼科用組成物のｐＨの低下を抑制する方法
KR20250160050A (ko) 2024-05-03 2025-11-11 삼천당제약주식회사 물리화학적 특성이 개선된 안구건조증 예방 또는 치료용 약학 조성물
CN119970633A (zh) * 2025-03-26 2025-05-13 苏州乐珠制药有限公司 一种地夸磷索钠滴眼液及其制备方法

Citations (1)

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Publication number Priority date Publication date Assignee Title
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CN103096929A (zh) * 2010-09-10 2013-05-08 参天制药株式会社 以组合p2y2受体激动剂和透明质酸或其盐为特征的干眼症治疗剂、干眼症的治疗方法、及干眼症治疗剂的应用
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TWI833406B (zh) * 2018-02-28 2024-02-21 日商參天製藥股份有限公司 含有迪夸弗索（Ｄｉｑｕａｆｏｓｏｌ）及陽離子性聚合物之眼科用組合物

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Also Published As

Publication number Publication date
KR20220052971A (ko) 2022-04-28
CN114286670B (zh) 2024-01-16
MY209059A (en) 2025-06-18
JP6966667B2 (ja) 2021-11-17
WO2021039748A1 (ja) 2021-03-04
KR102656181B1 (ko) 2024-04-08
JPWO2021039748A1 (ja) 2021-09-30
CN114286670A (zh) 2022-04-05
JP2022003099A (ja) 2022-01-11
CN117771172A (zh) 2024-03-29
TW202122094A (zh) 2021-06-16
JP2025031918A (ja) 2025-03-07
JP7614069B2 (ja) 2025-01-15
KR20240049646A (ko) 2024-04-16
PH12022550474A1 (en) 2023-03-06

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