TWI844570B - 用於即時預測的拉曼光譜模型之自動校準及自動維護 - Google Patents
用於即時預測的拉曼光譜模型之自動校準及自動維護 Download PDFInfo
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- TWI844570B TWI844570B TW108138146A TW108138146A TWI844570B TW I844570 B TWI844570 B TW I844570B TW 108138146 A TW108138146 A TW 108138146A TW 108138146 A TW108138146 A TW 108138146A TW I844570 B TWI844570 B TW I844570B
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/48—Automatic or computerized control
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- G—PHYSICS
- G06—COMPUTING OR CALCULATING; COUNTING
- G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
- G06N20/00—Machine learning
-
- G—PHYSICS
- G06—COMPUTING OR CALCULATING; COUNTING
- G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
- G06N5/00—Computing arrangements using knowledge-based models
- G06N5/04—Inference or reasoning models
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/20—Supervised data analysis
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N2021/8411—Application to online plant, process monitoring
- G01N2021/8416—Application to online plant, process monitoring and process controlling, not otherwise provided for
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/12—Circuits of general importance; Signal processing
- G01N2201/127—Calibration; base line adjustment; drift compensation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/12—Circuits of general importance; Signal processing
- G01N2201/129—Using chemometrical methods
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- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Theoretical Computer Science (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Software Systems (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Data Mining & Analysis (AREA)
- Medical Informatics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Artificial Intelligence (AREA)
- Evolutionary Computation (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Computing Systems (AREA)
- Mathematical Physics (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Evolutionary Biology (AREA)
- Biophysics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Computational Linguistics (AREA)
- Epidemiology (AREA)
- Databases & Information Systems (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862749359P | 2018-10-23 | 2018-10-23 | |
| US62/749,359 | 2018-10-23 | ||
| US201962833044P | 2019-04-12 | 2019-04-12 | |
| US62/833,044 | 2019-04-12 | ||
| US201962864565P | 2019-06-21 | 2019-06-21 | |
| US62/864,565 | 2019-06-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW202033949A TW202033949A (zh) | 2020-09-16 |
| TWI844570B true TWI844570B (zh) | 2024-06-11 |
Family
ID=70331744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW108138146A TWI844570B (zh) | 2018-10-23 | 2019-10-23 | 用於即時預測的拉曼光譜模型之自動校準及自動維護 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20220128474A1 (enExample) |
| EP (1) | EP3870957B1 (enExample) |
| JP (1) | JP7601760B2 (enExample) |
| KR (1) | KR20210078531A (enExample) |
| CN (1) | CN112912716B (enExample) |
| AU (2) | AU2019365102A1 (enExample) |
| CA (1) | CA3115296A1 (enExample) |
| CL (1) | CL2021001024A1 (enExample) |
| DK (1) | DK3870957T3 (enExample) |
| ES (1) | ES3041713T3 (enExample) |
| FI (1) | FI3870957T3 (enExample) |
| HU (1) | HUE072452T2 (enExample) |
| IL (1) | IL281977B2 (enExample) |
| LT (1) | LT3870957T (enExample) |
| MX (1) | MX2021004510A (enExample) |
| PL (1) | PL3870957T3 (enExample) |
| PT (1) | PT3870957T (enExample) |
| SG (1) | SG11202103232WA (enExample) |
| SI (1) | SI3870957T1 (enExample) |
| TW (1) | TWI844570B (enExample) |
| WO (1) | WO2020086635A1 (enExample) |
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| MY204234A (en) | 2018-08-27 | 2024-08-16 | Regeneron Pharma | Use of raman spectroscopy in downstream purification |
| WO2020251997A2 (en) * | 2019-06-10 | 2020-12-17 | Waters Technologies Corporation | Techniques for analytical instrument performance diagnostics |
| CN114730402A (zh) * | 2019-11-26 | 2022-07-08 | 萨默费尼根有限公司 | 分析设备的远程监控、故障排除和服务调度 |
| AU2021355381A1 (en) * | 2020-10-01 | 2023-05-04 | Amgen Inc. | Predictive modeling and control of cell culture |
| US20220138557A1 (en) * | 2020-11-04 | 2022-05-05 | Adobe Inc. | Deep Hybrid Graph-Based Forecasting Systems |
| US20210117841A1 (en) * | 2020-12-23 | 2021-04-22 | Intel Corporation | Methods, apparatus, and articles of manufacture to improve automated machine learning |
| DE102021100531B3 (de) * | 2021-01-13 | 2022-03-31 | BioThera Institut GmbH | Apparatur zum Steuern eines Prozesses sowie zugehöriges Steuerungsverfahren |
| CA3222382A1 (en) * | 2021-06-09 | 2022-12-15 | Amgen Inc. | Assessing packed cell volume for cell cultures |
| WO2022269464A1 (en) * | 2021-06-20 | 2022-12-29 | The State Of Israel, Ministry Of Agriculture & Rural Development Agricultural Research Organization (Aro) | Raman spectroscopy method and system for monitoring invasive species in algal bioreactors |
| JPWO2023053585A1 (enExample) * | 2021-09-30 | 2023-04-06 | ||
| WO2023076318A1 (en) | 2021-10-27 | 2023-05-04 | Amgen Inc. | Deep learning-based prediction for monitoring of pharmaceuticals using spectroscopy |
| JPWO2023090015A1 (enExample) * | 2021-11-22 | 2023-05-25 | ||
| JP7783091B2 (ja) * | 2022-02-25 | 2025-12-09 | 株式会社日立製作所 | 評価システム及び評価方法 |
| US12590283B2 (en) * | 2022-03-01 | 2026-03-31 | Amgen Inc. | Hybrid predictive modeling for control of cell culture |
| CN115308102B (zh) * | 2022-05-19 | 2025-07-01 | 芬欧汇川(中国)有限公司 | 纸张透气度测量方法以及纸张透气度测量系统 |
| US20240044801A1 (en) * | 2022-07-26 | 2024-02-08 | Thermo Scientific Portable Analytical Instruments Inc. | Autochemometric scientific instrument support systems |
| US20260064907A1 (en) * | 2022-08-29 | 2026-03-05 | Büchi Labortechnik AG | Methods for providing a predictive model for spectroscopy and calibrating a spectroscopic device |
| CN119790302A (zh) * | 2022-08-29 | 2025-04-08 | 美国安进公司 | 用于评估处理时间影响的预测模型 |
| CN119866430A (zh) | 2022-09-14 | 2025-04-22 | 美国安进公司 | 用变分自动编码器进行细胞培养过程监测和/或控制的即时学习 |
| JPWO2024079840A1 (enExample) * | 2022-10-13 | 2024-04-18 | ||
| JP2026502096A (ja) * | 2022-12-12 | 2026-01-21 | ジェネンテック， インコーポレイテッド | 限外濾過／透析濾過（ｕｆ／ｄｆ）コンディショニングおよび希釈プロセスのリアルタイム自動モニタリングと制御 |
| WO2024188962A1 (en) * | 2023-03-14 | 2024-09-19 | Katholieke Universiteit Leuven | Spectrum prediction methods for chemical processes |
| EP4672128A4 (en) | 2023-03-31 | 2026-05-20 | Fujifilm Corp | QUALITY MONITORING DEVICE, METHOD FOR OPERATION OF A QUALITY MONITORING DEVICE, AND PROGRAM FOR OPERATION OF A QUALITY MONITORING DEVICE |
| KR20250023079A (ko) | 2023-08-09 | 2025-02-18 | 주식회사 엘지화학 | 발효공정의 생성량 예측 시스템 및 방법 |
| CN117571684A (zh) * | 2023-11-20 | 2024-02-20 | 无锡药明生物技术股份有限公司 | 细胞培养液代谢物浓度确定方法、装置、设备和介质 |
| WO2025114830A1 (en) * | 2023-11-27 | 2025-06-05 | Avant Meats Company Limited | Control system and method for a perpetual automated bioprocessing system |
| CN122396912A (zh) | 2023-12-21 | 2026-07-14 | 勃林格殷格翰国际有限公司 | 用于分析流体样品的测量布置和方法 |
| CN118820281B (zh) * | 2024-09-19 | 2024-12-31 | 之江实验室 | 光谱数据库查询模型构建方法以及光谱数据库查询方法 |
| CN118819056B (zh) * | 2024-09-19 | 2024-12-31 | 天津医学高等专科学校(天津市护士学校) | 一种黄芩细胞悬浮培养优化控制系统 |
| EP4715492A1 (en) * | 2024-09-20 | 2026-03-25 | Sartorius Stedim Data Analytics AB | Monitoring and/or controlling a chemical and/or biological process |
| CN119223939B (zh) * | 2024-11-28 | 2025-04-01 | 合肥金星智控科技股份有限公司 | 基于libs的物料检测模型的自适应校准方法及装置 |
| WO2026136608A1 (en) * | 2024-12-18 | 2026-06-25 | Arranta Bio Holdings, Llc | Methods and arrangments for process analytical technology management and operation |
| CN121934525B (zh) * | 2026-03-30 | 2026-06-26 | 杭州市拱墅区边缘智能创新研究院 | 基于工业大模型的多智能体协同生产调度算法及系统 |
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| US20180238805A1 (en) * | 2015-07-22 | 2018-08-23 | The Board Of Regents Of The University Of Texas System | Label-free detection of sialic acid using surface-enhanced raman scattering microscopy |
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2019
- 2019-10-23 DK DK19848831.4T patent/DK3870957T3/da active
- 2019-10-23 ES ES19848831T patent/ES3041713T3/es active Active
- 2019-10-23 US US17/284,551 patent/US20220128474A1/en active Pending
- 2019-10-23 JP JP2021521530A patent/JP7601760B2/ja active Active
- 2019-10-23 HU HUE19848831A patent/HUE072452T2/hu unknown
- 2019-10-23 AU AU2019365102A patent/AU2019365102A1/en not_active Abandoned
- 2019-10-23 CN CN201980068986.7A patent/CN112912716B/zh active Active
- 2019-10-23 TW TW108138146A patent/TWI844570B/zh active
- 2019-10-23 FI FIEP19848831.4T patent/FI3870957T3/fi active
- 2019-10-23 PL PL19848831.4T patent/PL3870957T3/pl unknown
- 2019-10-23 CA CA3115296A patent/CA3115296A1/en active Pending
- 2019-10-23 EP EP19848831.4A patent/EP3870957B1/en active Active
- 2019-10-23 KR KR1020217015045A patent/KR20210078531A/ko active Pending
- 2019-10-23 LT LTEPPCT/US2019/057513T patent/LT3870957T/lt unknown
- 2019-10-23 PT PT198488314T patent/PT3870957T/pt unknown
- 2019-10-23 SI SI201930957T patent/SI3870957T1/sl unknown
- 2019-10-23 IL IL281977A patent/IL281977B2/en unknown
- 2019-10-23 SG SG11202103232WA patent/SG11202103232WA/en unknown
- 2019-10-23 WO PCT/US2019/057513 patent/WO2020086635A1/en not_active Ceased
- 2019-10-23 MX MX2021004510A patent/MX2021004510A/es unknown
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2021
- 2021-04-22 CL CL2021001024A patent/CL2021001024A1/es unknown
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2025
- 2025-07-11 AU AU2025205401A patent/AU2025205401A1/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102527307A (zh) * | 2002-10-28 | 2012-07-04 | 伊内奥斯美国公司 | 采用在线仪器数据转换的化学制造工艺和方法 |
| CN104541153A (zh) * | 2012-07-02 | 2015-04-22 | 新加坡国立大学 | 涉及利用光纤拉曼光谱的内窥镜进行实时癌症诊断的方法 |
| CN104541153B (zh) | 2012-07-02 | 2017-12-05 | 新加坡国立大学 | 涉及利用光纤拉曼光谱的内窥镜进行实时癌症诊断的方法 |
| US20180291329A1 (en) * | 2015-05-29 | 2018-10-11 | Biogen Ma Inc. | Cell culture methods and systems |
| US20180238805A1 (en) * | 2015-07-22 | 2018-08-23 | The Board Of Regents Of The University Of Texas System | Label-free detection of sialic acid using surface-enhanced raman scattering microscopy |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2019365102A1 (en) | 2021-04-29 |
| BR112021007611A2 (pt) | 2021-07-27 |
| CA3115296A1 (en) | 2020-04-30 |
| ES3041713T3 (en) | 2025-11-13 |
| MX2021004510A (es) | 2021-06-08 |
| LT3870957T (lt) | 2025-10-10 |
| CN112912716B (zh) | 2025-04-11 |
| WO2020086635A1 (en) | 2020-04-30 |
| FI3870957T3 (fi) | 2025-09-30 |
| IL281977B1 (en) | 2024-11-01 |
| DK3870957T3 (da) | 2025-09-29 |
| JP2022512775A (ja) | 2022-02-07 |
| CN112912716A (zh) | 2021-06-04 |
| US20220128474A1 (en) | 2022-04-28 |
| TW202033949A (zh) | 2020-09-16 |
| PT3870957T (pt) | 2025-09-01 |
| CL2021001024A1 (es) | 2021-09-24 |
| KR20210078531A (ko) | 2021-06-28 |
| SG11202103232WA (en) | 2021-05-28 |
| EP3870957A1 (en) | 2021-09-01 |
| IL281977B2 (en) | 2025-03-01 |
| EP3870957B1 (en) | 2025-07-16 |
| JP7601760B2 (ja) | 2024-12-17 |
| AU2025205401A1 (en) | 2025-07-31 |
| IL281977A (en) | 2021-05-31 |
| HUE072452T2 (hu) | 2025-11-28 |
| PL3870957T3 (pl) | 2025-11-17 |
| SI3870957T1 (sl) | 2025-10-30 |
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