JP7601760B2 - リアルタイム予測のためのラマン分光モデルの自動校正及び自動保守 - Google Patents

リアルタイム予測のためのラマン分光モデルの自動校正及び自動保守 Download PDF

Info

Publication number
JP7601760B2
JP7601760B2 JP2021521530A JP2021521530A JP7601760B2 JP 7601760 B2 JP7601760 B2 JP 7601760B2 JP 2021521530 A JP2021521530 A JP 2021521530A JP 2021521530 A JP2021521530 A JP 2021521530A JP 7601760 B2 JP7601760 B2 JP 7601760B2
Authority
JP
Japan
Prior art keywords
biopharmaceutical process
biopharmaceutical
analytical
query
observational
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2021521530A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022512775A (ja
JP2022512775A5 (enExample
Inventor
トゥルシャン,アディティア
Original Assignee
アムジエン・インコーポレーテツド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=70331744&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP7601760(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by アムジエン・インコーポレーテツド filed Critical アムジエン・インコーポレーテツド
Publication of JP2022512775A publication Critical patent/JP2022512775A/ja
Publication of JP2022512775A5 publication Critical patent/JP2022512775A5/ja
Application granted granted Critical
Publication of JP7601760B2 publication Critical patent/JP7601760B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N20/00—Machine learning
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N5/00—Computing arrangements using knowledge-based models
    • G06N5/04—Inference or reasoning models
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N2021/8411—Application to online plant, process monitoring
    • G01N2021/8416—Application to online plant, process monitoring and process controlling, not otherwise provided for
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/127—Calibration; base line adjustment; drift compensation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/129—Using chemometrical methods

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Software Systems (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Data Mining & Analysis (AREA)
  • Medical Informatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Artificial Intelligence (AREA)
  • Evolutionary Computation (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Computing Systems (AREA)
  • Mathematical Physics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Evolutionary Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Computational Linguistics (AREA)
  • Epidemiology (AREA)
  • Databases & Information Systems (AREA)
JP2021521530A 2018-10-23 2019-10-23 リアルタイム予測のためのラマン分光モデルの自動校正及び自動保守 Active JP7601760B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862749359P 2018-10-23 2018-10-23
US62/749,359 2018-10-23
US201962833044P 2019-04-12 2019-04-12
US62/833,044 2019-04-12
US201962864565P 2019-06-21 2019-06-21
US62/864,565 2019-06-21
PCT/US2019/057513 WO2020086635A1 (en) 2018-10-23 2019-10-23 Automatic calibration and automatic maintenance of raman spectroscopic models for real-time predictions

Publications (3)

Publication Number Publication Date
JP2022512775A JP2022512775A (ja) 2022-02-07
JP2022512775A5 JP2022512775A5 (enExample) 2022-10-26
JP7601760B2 true JP7601760B2 (ja) 2024-12-17

Family

ID=70331744

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021521530A Active JP7601760B2 (ja) 2018-10-23 2019-10-23 リアルタイム予測のためのラマン分光モデルの自動校正及び自動保守

Country Status (21)

Country Link
US (1) US20220128474A1 (enExample)
EP (1) EP3870957B1 (enExample)
JP (1) JP7601760B2 (enExample)
KR (1) KR20210078531A (enExample)
CN (1) CN112912716B (enExample)
AU (2) AU2019365102A1 (enExample)
CA (1) CA3115296A1 (enExample)
CL (1) CL2021001024A1 (enExample)
DK (1) DK3870957T3 (enExample)
ES (1) ES3041713T3 (enExample)
FI (1) FI3870957T3 (enExample)
HU (1) HUE072452T2 (enExample)
IL (1) IL281977B2 (enExample)
LT (1) LT3870957T (enExample)
MX (1) MX2021004510A (enExample)
PL (1) PL3870957T3 (enExample)
PT (1) PT3870957T (enExample)
SG (1) SG11202103232WA (enExample)
SI (1) SI3870957T1 (enExample)
TW (1) TWI844570B (enExample)
WO (1) WO2020086635A1 (enExample)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY204234A (en) 2018-08-27 2024-08-16 Regeneron Pharma Use of raman spectroscopy in downstream purification
WO2020251997A2 (en) * 2019-06-10 2020-12-17 Waters Technologies Corporation Techniques for analytical instrument performance diagnostics
CN114730402A (zh) * 2019-11-26 2022-07-08 萨默费尼根有限公司 分析设备的远程监控、故障排除和服务调度
AU2021355381A1 (en) * 2020-10-01 2023-05-04 Amgen Inc. Predictive modeling and control of cell culture
US20220138557A1 (en) * 2020-11-04 2022-05-05 Adobe Inc. Deep Hybrid Graph-Based Forecasting Systems
US20210117841A1 (en) * 2020-12-23 2021-04-22 Intel Corporation Methods, apparatus, and articles of manufacture to improve automated machine learning
DE102021100531B3 (de) * 2021-01-13 2022-03-31 BioThera Institut GmbH Apparatur zum Steuern eines Prozesses sowie zugehöriges Steuerungsverfahren
CA3222382A1 (en) * 2021-06-09 2022-12-15 Amgen Inc. Assessing packed cell volume for cell cultures
WO2022269464A1 (en) * 2021-06-20 2022-12-29 The State Of Israel, Ministry Of Agriculture & Rural Development Agricultural Research Organization (Aro) Raman spectroscopy method and system for monitoring invasive species in algal bioreactors
JPWO2023053585A1 (enExample) * 2021-09-30 2023-04-06
WO2023076318A1 (en) 2021-10-27 2023-05-04 Amgen Inc. Deep learning-based prediction for monitoring of pharmaceuticals using spectroscopy
JPWO2023090015A1 (enExample) * 2021-11-22 2023-05-25
JP7783091B2 (ja) * 2022-02-25 2025-12-09 株式会社日立製作所 評価システム及び評価方法
US12590283B2 (en) * 2022-03-01 2026-03-31 Amgen Inc. Hybrid predictive modeling for control of cell culture
CN115308102B (zh) * 2022-05-19 2025-07-01 芬欧汇川(中国)有限公司 纸张透气度测量方法以及纸张透气度测量系统
US20240044801A1 (en) * 2022-07-26 2024-02-08 Thermo Scientific Portable Analytical Instruments Inc. Autochemometric scientific instrument support systems
US20260064907A1 (en) * 2022-08-29 2026-03-05 Büchi Labortechnik AG Methods for providing a predictive model for spectroscopy and calibrating a spectroscopic device
CN119790302A (zh) * 2022-08-29 2025-04-08 美国安进公司 用于评估处理时间影响的预测模型
CN119866430A (zh) 2022-09-14 2025-04-22 美国安进公司 用变分自动编码器进行细胞培养过程监测和/或控制的即时学习
JPWO2024079840A1 (enExample) * 2022-10-13 2024-04-18
JP2026502096A (ja) * 2022-12-12 2026-01-21 ジェネンテック, インコーポレイテッド 限外濾過/透析濾過(uf/df)コンディショニングおよび希釈プロセスのリアルタイム自動モニタリングと制御
WO2024188962A1 (en) * 2023-03-14 2024-09-19 Katholieke Universiteit Leuven Spectrum prediction methods for chemical processes
EP4672128A4 (en) 2023-03-31 2026-05-20 Fujifilm Corp QUALITY MONITORING DEVICE, METHOD FOR OPERATION OF A QUALITY MONITORING DEVICE, AND PROGRAM FOR OPERATION OF A QUALITY MONITORING DEVICE
KR20250023079A (ko) 2023-08-09 2025-02-18 주식회사 엘지화학 발효공정의 생성량 예측 시스템 및 방법
CN117571684A (zh) * 2023-11-20 2024-02-20 无锡药明生物技术股份有限公司 细胞培养液代谢物浓度确定方法、装置、设备和介质
WO2025114830A1 (en) * 2023-11-27 2025-06-05 Avant Meats Company Limited Control system and method for a perpetual automated bioprocessing system
CN122396912A (zh) 2023-12-21 2026-07-14 勃林格殷格翰国际有限公司 用于分析流体样品的测量布置和方法
CN118820281B (zh) * 2024-09-19 2024-12-31 之江实验室 光谱数据库查询模型构建方法以及光谱数据库查询方法
CN118819056B (zh) * 2024-09-19 2024-12-31 天津医学高等专科学校(天津市护士学校) 一种黄芩细胞悬浮培养优化控制系统
EP4715492A1 (en) * 2024-09-20 2026-03-25 Sartorius Stedim Data Analytics AB Monitoring and/or controlling a chemical and/or biological process
CN119223939B (zh) * 2024-11-28 2025-04-01 合肥金星智控科技股份有限公司 基于libs的物料检测模型的自适应校准方法及装置
WO2026136608A1 (en) * 2024-12-18 2026-06-25 Arranta Bio Holdings, Llc Methods and arrangments for process analytical technology management and operation
CN121934525B (zh) * 2026-03-30 2026-06-26 杭州市拱墅区边缘智能创新研究院 基于工业大模型的多智能体协同生产调度算法及系统

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080244251A1 (en) 2007-03-29 2008-10-02 Khipu Systems Limited Predictive model implementation system and methodology
US20090119244A1 (en) 2007-10-30 2009-05-07 Chimenti Robert J Bootstrap method for oil property prediction
US20120072122A1 (en) 2005-06-09 2012-03-22 Chemimage Corporation Forensic Integrated Search Technology
US20130311136A1 (en) 2012-05-18 2013-11-21 Mustard Tree Instruments, Llc Rule-Based Sample Verification and Chemical Monitoring Methodology
US20140046641A1 (en) 2007-11-02 2014-02-13 Ceres, Inc. Materials and Methods for Use in Biomass Processing
JP2015522249A (ja) 2012-04-04 2015-08-06 ベーイーオー・メリュー 分光分析および構造化分類による微生物の同定

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6319494B1 (en) 1990-12-14 2001-11-20 Cell Genesys, Inc. Chimeric chains for receptor-associated signal transduction pathways
IL104570A0 (en) 1992-03-18 1993-05-13 Yeda Res & Dev Chimeric genes and cells transformed therewith
US5862060A (en) * 1996-11-22 1999-01-19 Uop Llc Maintenance of process control by statistical analysis of product optical spectrum
CA2326389C (en) 1998-04-21 2007-01-23 Micromet Gesellschaft Fur Biomedizinische Forschung Mbh Novel cd19xcd3 specific polypeptides and uses thereof
US7398119B2 (en) * 1998-07-13 2008-07-08 Childrens Hospital Los Angeles Assessing blood brain barrier dynamics or identifying or measuring selected substances, including ethanol or toxins, in a subject by analyzing Raman spectrum signals
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
US7138370B2 (en) 2001-10-11 2006-11-21 Amgen Inc. Specific binding agents of human angiopoietin-2
WO2004040283A2 (en) * 2002-10-28 2004-05-13 Bp Corporation North America Inc. Control of a polymerization process
AU2003301195B2 (en) 2002-12-20 2010-01-07 Amgen Inc. Binding agents which inhibit myostatin
JP4745959B2 (ja) * 2003-05-12 2011-08-10 リバー・ダイアグノスティクス・ビー.・ブイ. 微生物の自動特徴づけおよび分類
US8076459B2 (en) 2003-10-16 2011-12-13 Micromet Ag Multispecfic deimmunized CD3-binders
WO2008119567A2 (en) 2007-04-03 2008-10-09 Micromet Ag Cross-species-specific cd3-epsilon binding domain
US7961312B2 (en) * 2007-08-13 2011-06-14 C8 Medisensors Inc. Calibrated analyte concentration measurements in mixtures
US8725667B2 (en) * 2008-03-08 2014-05-13 Tokyo Electron Limited Method and system for detection of tool performance degradation and mismatch
GB2466442A (en) * 2008-12-18 2010-06-23 Dublin Inst Of Technology A system to analyze a sample on a slide using Raman spectroscopy on an identified area of interest
CN101825567A (zh) * 2010-04-02 2010-09-08 南开大学 一种近红外光谱和拉曼光谱波长的筛选方法
JP6407726B2 (ja) 2012-03-01 2018-10-24 アムゲン リサーチ (ミュンヘン) ゲーエムベーハーAMGEN Research(Munich)GmbH 長寿命ポリペプチド結合分子
GB2513343A (en) * 2013-04-23 2014-10-29 Univ Singapore Methods related to instrument-independent measurements for quantitative analysis of fiber-optic Raman spectroscopy
US20140114676A1 (en) * 2012-10-23 2014-04-24 Theranos, Inc. Drug Monitoring and Regulation Systems and Methods
UY35484A (es) 2013-03-15 2014-10-31 Amgen Res Munich Gmbh Molécula de unión de cadena simple que comprenden ABP de extremo N
WO2014151910A1 (en) 2013-03-15 2014-09-25 Amgen Inc. Heterodimeric bispecific antibodies
US20140302037A1 (en) 2013-03-15 2014-10-09 Amgen Inc. BISPECIFIC-Fc MOLECULES
US20140308285A1 (en) 2013-03-15 2014-10-16 Amgen Inc. Heterodimeric bispecific antibodies
CN104215623B (zh) * 2013-05-31 2018-09-25 欧普图斯(苏州)光学纳米科技有限公司 面向多行业检测的激光拉曼光谱智能化辨识方法及系统
WO2015048272A1 (en) 2013-09-25 2015-04-02 Amgen Inc. V-c-fc-v-c antibody
EP3164481A4 (en) * 2014-07-02 2018-03-21 Biogen MA Inc. Cross-scale modeling of bioreactor cultures using raman spectroscopy
US20180291329A1 (en) * 2015-05-29 2018-10-11 Biogen Ma Inc. Cell culture methods and systems
MX393857B (es) * 2015-07-22 2025-03-24 Univ Autonoma De San Luis Potosi Detección cuantitativa del ácido siálico utilizando el efecto raman realzado por superficies.
EA039859B1 (ru) 2015-07-31 2022-03-21 Эмджен Рисерч (Мюник) Гмбх Биспецифические конструкты антител, связывающие egfrviii и cd3
WO2017083593A1 (en) * 2015-11-10 2017-05-18 Massachusetts Institute Of Technology Systems and methods for sampling calibration of non-invasive analyte measurements
DK3291038T3 (da) 2016-08-31 2021-10-18 Sartorius Stedim Biotech Gmbh Kontrol og overvågning af en proces til fremstilling af et kemisk, farmaceutisk eller bioteknologisk produkt
IL272472B2 (en) * 2017-10-16 2026-05-01 Regeneron Pharma In-situ Raman spectroscopy systems and methods for controlling process variables in cell cultures
US10810408B2 (en) * 2018-01-26 2020-10-20 Viavi Solutions Inc. Reduced false positive identification for spectroscopic classification

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120072122A1 (en) 2005-06-09 2012-03-22 Chemimage Corporation Forensic Integrated Search Technology
US20080244251A1 (en) 2007-03-29 2008-10-02 Khipu Systems Limited Predictive model implementation system and methodology
US20090119244A1 (en) 2007-10-30 2009-05-07 Chimenti Robert J Bootstrap method for oil property prediction
US20140046641A1 (en) 2007-11-02 2014-02-13 Ceres, Inc. Materials and Methods for Use in Biomass Processing
JP2015522249A (ja) 2012-04-04 2015-08-06 ベーイーオー・メリュー 分光分析および構造化分類による微生物の同定
US20130311136A1 (en) 2012-05-18 2013-11-21 Mustard Tree Instruments, Llc Rule-Based Sample Verification and Chemical Monitoring Methodology

Also Published As

Publication number Publication date
AU2019365102A1 (en) 2021-04-29
BR112021007611A2 (pt) 2021-07-27
CA3115296A1 (en) 2020-04-30
ES3041713T3 (en) 2025-11-13
MX2021004510A (es) 2021-06-08
LT3870957T (lt) 2025-10-10
CN112912716B (zh) 2025-04-11
WO2020086635A1 (en) 2020-04-30
FI3870957T3 (fi) 2025-09-30
IL281977B1 (en) 2024-11-01
DK3870957T3 (da) 2025-09-29
JP2022512775A (ja) 2022-02-07
CN112912716A (zh) 2021-06-04
US20220128474A1 (en) 2022-04-28
TW202033949A (zh) 2020-09-16
PT3870957T (pt) 2025-09-01
CL2021001024A1 (es) 2021-09-24
KR20210078531A (ko) 2021-06-28
SG11202103232WA (en) 2021-05-28
EP3870957A1 (en) 2021-09-01
IL281977B2 (en) 2025-03-01
EP3870957B1 (en) 2025-07-16
AU2025205401A1 (en) 2025-07-31
IL281977A (en) 2021-05-31
HUE072452T2 (hu) 2025-11-28
TWI844570B (zh) 2024-06-11
PL3870957T3 (pl) 2025-11-17
SI3870957T1 (sl) 2025-10-30

Similar Documents

Publication Publication Date Title
TWI844570B (zh) 用於即時預測的拉曼光譜模型之自動校準及自動維護
JP2025500732A (ja) 分光法を使用して薬剤を監視するための深層学習ベースの予測
AU2026201984A1 (en) Microchip capillary electrophoresis assays and reagents
Yang et al. Multi‐criteria manufacturability indices for ranking high‐concentration monoclonal antibody formulations
CN114008713A (zh) 信息处理系统、信息处理方法、程序、以及制备抗原结合分子或蛋白质的方法
KR20220084321A (ko) 라만 분광법에 기반한 생물학적 제제의 식별을 위한 구성가능한 휴대용 생물학적 분석기
Schiel et al. Monoclonal antibody therapeutics: the need for biopharmaceutical reference materials
EP4439053A1 (en) Information processing device, method for operating information processing device, operation program for information processing device, method for generating calibrated state prediction model, and calibrated state prediction model
HK40053280B (en) Automatic calibration and automatic maintenance of spectroscopic models for real-time predictions
HK40053280A (en) Automatic calibration and automatic maintenance of spectroscopic models for real-time predictions
BR112021007611B1 (pt) Método implementado por computador, sistema de espectroscopia, mídia legível por computador não transitória e sistema de biorreator para calibração automática e manutenção automática de modelos espectroscópicos raman para previsões em tempo real
EA043314B1 (ru) Автоматическая калибровка и автоматическое обслуживание рамановских спектроскопических моделей для предсказаний в реальном времени
CN121605481A (zh) 信息处理系统、信息处理方法、程序和用于制造分子化合物的方法
TW202016125A (zh) 用於定量及調節蛋白質黏度之系統與方法
CN121464336A (zh) 用于使用人工智能基于拉曼光谱法鉴定生物产品的可配置手持式生物分析仪
US20230071627A1 (en) Multivariate Bracketing Approach for Sterile Filter Validation
US11566347B2 (en) Antibody variants
Aubrey et al. Antibody fragments humanization: Beginning with the end in mind
Abidi et al. Process Analytical Technologies (PAT) for Accurate Quantification of Monoclonal Antibodies (mAbs)
WO2024263980A1 (en) Methods and systems for determining an impact of attributes
HK40063830A (en) Information processing system, information processing method, program, and method for producing antigen-binding molecule or protein
Joshi The development of next-generation small volume biophysical screening for the early assessment of monoclonal antibody manufacturability
JP2025534958A (ja) 細胞培養プロセスの監視及び/又は制御のための変分オートエンコーダによるジャストインタイムラーニング
Fang Crystal ball planning for analytics implementation in Singapore
EA052158B1 (ru) Применение рамановской спектроскопии для последующей очистки

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20221018

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20221018

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20240109

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20240403

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240415

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20240709

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240904

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20241112

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20241205

R150 Certificate of patent or registration of utility model

Ref document number: 7601760

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150