IL281977B2 - Automatic calibration and automatic maintenance of raman spectroscopic models for real-time predictions - Google Patents

Automatic calibration and automatic maintenance of raman spectroscopic models for real-time predictions

Info

Publication number
IL281977B2
IL281977B2 IL281977A IL28197721A IL281977B2 IL 281977 B2 IL281977 B2 IL 281977B2 IL 281977 A IL281977 A IL 281977A IL 28197721 A IL28197721 A IL 28197721A IL 281977 B2 IL281977 B2 IL 281977B2
Authority
IL
Israel
Prior art keywords
biopharmaceutical
analytical measurement
query point
biopharmaceutical process
processors
Prior art date
Application number
IL281977A
Other languages
English (en)
Hebrew (he)
Other versions
IL281977B1 (en
IL281977A (en
Inventor
Aditya Tulsyan
Original Assignee
Rocky Research
Aditya Tulsyan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=70331744&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL281977(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rocky Research, Aditya Tulsyan filed Critical Rocky Research
Publication of IL281977A publication Critical patent/IL281977A/en
Publication of IL281977B1 publication Critical patent/IL281977B1/en
Publication of IL281977B2 publication Critical patent/IL281977B2/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N20/00—Machine learning
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N5/00—Computing arrangements using knowledge-based models
    • G06N5/04—Inference or reasoning models
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N2021/8411—Application to online plant, process monitoring
    • G01N2021/8416—Application to online plant, process monitoring and process controlling, not otherwise provided for
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/127—Calibration; base line adjustment; drift compensation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/129—Using chemometrical methods

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Software Systems (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Data Mining & Analysis (AREA)
  • Medical Informatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Artificial Intelligence (AREA)
  • Evolutionary Computation (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Computing Systems (AREA)
  • Mathematical Physics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Evolutionary Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Computational Linguistics (AREA)
  • Epidemiology (AREA)
  • Databases & Information Systems (AREA)
IL281977A 2018-10-23 2019-10-23 Automatic calibration and automatic maintenance of raman spectroscopic models for real-time predictions IL281977B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862749359P 2018-10-23 2018-10-23
US201962833044P 2019-04-12 2019-04-12
US201962864565P 2019-06-21 2019-06-21
PCT/US2019/057513 WO2020086635A1 (en) 2018-10-23 2019-10-23 Automatic calibration and automatic maintenance of raman spectroscopic models for real-time predictions

Publications (3)

Publication Number Publication Date
IL281977A IL281977A (en) 2021-05-31
IL281977B1 IL281977B1 (en) 2024-11-01
IL281977B2 true IL281977B2 (en) 2025-03-01

Family

ID=70331744

Family Applications (1)

Application Number Title Priority Date Filing Date
IL281977A IL281977B2 (en) 2018-10-23 2019-10-23 Automatic calibration and automatic maintenance of raman spectroscopic models for real-time predictions

Country Status (21)

Country Link
US (1) US20220128474A1 (enExample)
EP (1) EP3870957B1 (enExample)
JP (1) JP7601760B2 (enExample)
KR (1) KR20210078531A (enExample)
CN (1) CN112912716B (enExample)
AU (2) AU2019365102A1 (enExample)
CA (1) CA3115296A1 (enExample)
CL (1) CL2021001024A1 (enExample)
DK (1) DK3870957T3 (enExample)
ES (1) ES3041713T3 (enExample)
FI (1) FI3870957T3 (enExample)
HU (1) HUE072452T2 (enExample)
IL (1) IL281977B2 (enExample)
LT (1) LT3870957T (enExample)
MX (1) MX2021004510A (enExample)
PL (1) PL3870957T3 (enExample)
PT (1) PT3870957T (enExample)
SG (1) SG11202103232WA (enExample)
SI (1) SI3870957T1 (enExample)
TW (1) TWI844570B (enExample)
WO (1) WO2020086635A1 (enExample)

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CN117571684A (zh) * 2023-11-20 2024-02-20 无锡药明生物技术股份有限公司 细胞培养液代谢物浓度确定方法、装置、设备和介质
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Also Published As

Publication number Publication date
AU2019365102A1 (en) 2021-04-29
BR112021007611A2 (pt) 2021-07-27
CA3115296A1 (en) 2020-04-30
ES3041713T3 (en) 2025-11-13
MX2021004510A (es) 2021-06-08
LT3870957T (lt) 2025-10-10
CN112912716B (zh) 2025-04-11
WO2020086635A1 (en) 2020-04-30
FI3870957T3 (fi) 2025-09-30
IL281977B1 (en) 2024-11-01
DK3870957T3 (da) 2025-09-29
JP2022512775A (ja) 2022-02-07
CN112912716A (zh) 2021-06-04
US20220128474A1 (en) 2022-04-28
TW202033949A (zh) 2020-09-16
PT3870957T (pt) 2025-09-01
CL2021001024A1 (es) 2021-09-24
KR20210078531A (ko) 2021-06-28
SG11202103232WA (en) 2021-05-28
EP3870957A1 (en) 2021-09-01
EP3870957B1 (en) 2025-07-16
JP7601760B2 (ja) 2024-12-17
AU2025205401A1 (en) 2025-07-31
IL281977A (en) 2021-05-31
HUE072452T2 (hu) 2025-11-28
TWI844570B (zh) 2024-06-11
PL3870957T3 (pl) 2025-11-17
SI3870957T1 (sl) 2025-10-30

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