TWI841523B - 治療及/或預防光化性角化症之方法 - Google Patents

治療及/或預防光化性角化症之方法 Download PDF

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Publication number
TWI841523B
TWI841523B TW107108242A TW107108242A TWI841523B TW I841523 B TWI841523 B TW I841523B TW 107108242 A TW107108242 A TW 107108242A TW 107108242 A TW107108242 A TW 107108242A TW I841523 B TWI841523 B TW I841523B
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TW107108242A
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TW201842913A (zh
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魯道夫 關
耀南 劉
伊道格拉斯 克拉莫
大衛 卡勒
榮生 方
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美商Atnx特殊目的實體公司
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW107108242A 2017-03-10 2018-03-12 治療及/或預防光化性角化症之方法 TWI841523B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762469889P 2017-03-10 2017-03-10
US62/469,889 2017-03-10

Publications (2)

Publication Number Publication Date
TW201842913A TW201842913A (zh) 2018-12-16
TWI841523B true TWI841523B (zh) 2024-05-11

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ID=63446658

Family Applications (1)

Application Number Title Priority Date Filing Date
TW107108242A TWI841523B (zh) 2017-03-10 2018-03-12 治療及/或預防光化性角化症之方法

Country Status (13)

Country Link
US (3) US10617693B2 (enExample)
EP (2) EP4659740A2 (enExample)
JP (3) JP7502863B2 (enExample)
KR (2) KR20190141661A (enExample)
CN (1) CN110891575A (enExample)
AU (2) AU2018231144B2 (enExample)
BR (1) BR112019018687A2 (enExample)
CA (1) CA3055938A1 (enExample)
IL (1) IL269182B2 (enExample)
MX (2) MX387658B (enExample)
TW (1) TWI841523B (enExample)
WO (1) WO2018165647A1 (enExample)
ZA (1) ZA202100106B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7968574B2 (en) * 2004-12-28 2011-06-28 Kinex Pharmaceuticals, Llc Biaryl compositions and methods for modulating a kinase cascade
CN110891575A (zh) * 2017-03-10 2020-03-17 雅培克公司 治疗和/或预防光化性角化病的方法
KR102691700B1 (ko) 2017-09-07 2024-08-02 아테넥스 에이치케이 이노베이티브 리미티드 2-(5-(4-(2-모르폴리노에톡시)페닐)피리딘-2-일)-n-벤질아세트아미드의 고체 형태
EP3761988A4 (en) * 2018-03-07 2021-12-29 Athenex HK Innovative Limited Compositions and methods for treating hyperproliferative skin disorders
WO2019188918A1 (ja) * 2018-03-28 2019-10-03 テルモ株式会社 医療デバイスおよび処置用法
AU2020288640A1 (en) * 2019-06-05 2021-12-23 Atnx Spv, Llc Methods of treating and/or preventing psoriasis
JP2024506240A (ja) * 2021-01-21 2024-02-13 サーナオミクス インコーポレイテッド 皮膚がんの治療のための組成物および方法
WO2025077886A1 (zh) * 2023-10-13 2025-04-17 恩康药业科技(广州)有限公司 治疗和/或预防日光性角化病的化合物及方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7968574B2 (en) 2004-12-28 2011-06-28 Kinex Pharmaceuticals, Llc Biaryl compositions and methods for modulating a kinase cascade
CN101184734B (zh) 2004-12-28 2013-05-29 金克斯医药品有限公司 治疗细胞增殖紊乱的化合物和方法
EP2041071B1 (en) 2006-06-29 2014-06-18 Kinex Pharmaceuticals, LLC Biaryl compositions and methods for modulating a kinase cascade
WO2008030892A2 (en) 2006-09-05 2008-03-13 Bipar Sciences, Inc. Drug design for tubulin inhibitors, compositions, and methods of treatment thereof
TWI457336B (zh) 2006-12-28 2014-10-21 Kinex Pharmaceuticals Llc 調節激酶級聯之組成物及方法
US7939529B2 (en) 2007-05-17 2011-05-10 Kinex Pharmaceuticals, Llc Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof
US7935697B2 (en) 2006-12-28 2011-05-03 Kinex Pharmaceuticals, Llc Compositions for modulating a kinase cascade and methods of use thereof
CN101687798B (zh) 2007-05-17 2012-08-15 金克斯医药品有限公司 制备用于调节激酶级联的组合物的过程及其使用方法
EP2143421A1 (en) 2008-07-07 2010-01-13 Almirall Hermal GmbH Topical composition for the treatment of actinic keratosis
AU2009335943A1 (en) * 2008-12-19 2013-10-24 Medicis Pharmaceutical Corporation Lower dosage strength imiquimod formulations and short dosing regimens for treating actinic keratosis
US8741857B1 (en) 2012-01-30 2014-06-03 Lawrence Moy Treatments for actinic keratoses
NZ606177A (en) 2012-01-30 2014-03-28 Dolorgiet Gmbh & Co Kg Compositions for the treatment of actinic keratosis
BR112014032346A2 (pt) 2012-06-26 2017-06-27 Del Mar Pharmaceuticals métodos para tratamento de malignidades resistentes ao inibidor de tirosina-quinase em pacientes com polimorfismos genéticos ou desregulações de ahi1 mutações empregando dianidrogalactitol, diacetildianidrogalactitol, dibromodulcitol, ou análogos ou derivados destes
CN110891575A (zh) * 2017-03-10 2020-03-17 雅培克公司 治疗和/或预防光化性角化病的方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
期刊 BUFFALO, N.Y Kinex Pharmaceuticals Announces Allowance of the Investigational New Drug (IND) application for KX2-391 Ointment by the United States Food and Drug Administration (FDA) Kinex Pharmaceuticals VOL1 July 2014 1-2

Also Published As

Publication number Publication date
EP3592355B1 (en) 2025-12-10
JP2023015269A (ja) 2023-01-31
KR20190141661A (ko) 2019-12-24
WO2018165647A1 (en) 2018-09-13
MX387658B (es) 2025-03-18
IL269182B1 (en) 2023-07-01
TW201842913A (zh) 2018-12-16
US20230172942A1 (en) 2023-06-08
US20180256589A1 (en) 2018-09-13
EP3592355A1 (en) 2020-01-15
AU2018231144A1 (en) 2019-10-03
MX2019010707A (es) 2020-01-15
JP2020510042A (ja) 2020-04-02
AU2024201828A1 (en) 2024-05-02
IL269182B2 (en) 2023-11-01
EP4659740A2 (en) 2025-12-10
MX2021013354A (es) 2021-11-18
US20200197405A1 (en) 2020-06-25
EP3592355A4 (en) 2021-01-06
US11497750B2 (en) 2022-11-15
BR112019018687A2 (pt) 2020-04-07
JP7502863B2 (ja) 2024-06-19
IL269182A (en) 2019-11-28
JP2025029010A (ja) 2025-03-05
AU2018231144B2 (en) 2023-12-21
KR20240090837A (ko) 2024-06-21
ZA202100106B (en) 2022-08-31
CA3055938A1 (en) 2018-09-13
US10617693B2 (en) 2020-04-14
RU2019131757A (ru) 2021-04-12
RU2019131757A3 (enExample) 2021-05-31
CN110891575A (zh) 2020-03-17

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