TWI841209B - 用抗tim-3抗體治療癌症之方法 - Google Patents

用抗tim-3抗體治療癌症之方法 Download PDF

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Publication number
TWI841209B
TWI841209B TW112102836A TW112102836A TWI841209B TW I841209 B TWI841209 B TW I841209B TW 112102836 A TW112102836 A TW 112102836A TW 112102836 A TW112102836 A TW 112102836A TW I841209 B TWI841209 B TW I841209B
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cancer
specific example
tim
inhibitor
antibody
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TW112102836A
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Chinese (zh)
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TW202319068A (zh
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狄米崔 包黎夫
安德魯 R 佛格森
克莉絲汀 安妮 麥伊恆
王晶
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美商提薩羅有限公司
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507Comprising a combination of two or more separate antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/53Hinge
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW112102836A 2017-01-09 2018-01-09 用抗tim-3抗體治療癌症之方法 TWI841209B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762444354P 2017-01-09 2017-01-09
US62/444,354 2017-01-09
US201762582272P 2017-11-06 2017-11-06
US62/582,272 2017-11-06

Publications (2)

Publication Number Publication Date
TW202319068A TW202319068A (zh) 2023-05-16
TWI841209B true TWI841209B (zh) 2024-05-01

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TW112102836A TWI841209B (zh) 2017-01-09 2018-01-09 用抗tim-3抗體治療癌症之方法
TW107100821A TWI793094B (zh) 2017-01-09 2018-01-09 用抗tim-3抗體治療癌症之方法

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US (2) US11926665B2 (enExample)
EP (1) EP3565594A1 (enExample)
JP (2) JP7118073B2 (enExample)
KR (1) KR102671283B1 (enExample)
CN (1) CN110382000A (enExample)
AU (1) AU2018205401B2 (enExample)
BR (1) BR112019014169A2 (enExample)
CA (1) CA3049536A1 (enExample)
IL (1) IL267803A (enExample)
MA (1) MA47206A (enExample)
MX (1) MX2019008208A (enExample)
SG (1) SG10201913083SA (enExample)
TW (2) TWI841209B (enExample)
WO (1) WO2018129553A1 (enExample)

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Publication number Publication date
JP2020503364A (ja) 2020-01-30
SG10201913083SA (en) 2020-03-30
KR102671283B1 (ko) 2024-06-03
JP7118073B2 (ja) 2022-08-15
TW202319068A (zh) 2023-05-16
JP7472190B2 (ja) 2024-04-22
CN110382000A (zh) 2019-10-25
BR112019014169A2 (pt) 2020-02-11
TW201831196A (zh) 2018-09-01
JP2022087185A (ja) 2022-06-09
IL267803A (en) 2019-09-26
MX2019008208A (es) 2019-12-11
TWI793094B (zh) 2023-02-21
AU2018205401B2 (en) 2025-01-02
CA3049536A1 (en) 2018-07-12
KR20190098263A (ko) 2019-08-21
EP3565594A1 (en) 2019-11-13
US11926665B2 (en) 2024-03-12
US20240301057A1 (en) 2024-09-12
US20190322746A1 (en) 2019-10-24
AU2018205401A1 (en) 2019-07-25
MA47206A (fr) 2019-11-13
WO2018129553A1 (en) 2018-07-12

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