TWI832945B - 血糖值上昇抑制用、血中三酸甘油酯上昇抑制用組成物 - Google Patents
血糖值上昇抑制用、血中三酸甘油酯上昇抑制用組成物 Download PDFInfo
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- TWI832945B TWI832945B TW108147413A TW108147413A TWI832945B TW I832945 B TWI832945 B TW I832945B TW 108147413 A TW108147413 A TW 108147413A TW 108147413 A TW108147413 A TW 108147413A TW I832945 B TWI832945 B TW I832945B
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Abstract
本發明之課題係提供一種新穎之餐後血糖值上昇抑制用及/或餐後血中三酸甘油酯上昇抑制用組成物。本發明解決上述課題之方案係一種餐後血糖值上昇抑制用及/或餐後血中三酸甘油酯上昇抑制用組成物,其含有茶花萃取物、桑葉萃取物、聚葡萄胺糖作為有效成分。
Description
本發明係有關一種餐後血糖值上昇抑制用及/或血中三酸甘油酯上昇抑制用組成物,其含有茶花萃取物、桑葉萃取物、聚葡萄胺糖作為有效成分。
肥胖多在中年以後,根據統計結果,40至70多歲的男性中有30%以上的人為肥胖,而女性中則有20至30%的人為肥胖。肥胖已被認定為會提高包括癌症、心臟病、腦血管疾病之所謂3大死因的該等疾病之風險。肥胖係被認為是由於碳水化合物的過量攝取以及油膩甜食、甜飲料的攝取量增加所致。以改善如此飲食生活之目的而製定了「飲食生活指南」及「飲食平衡指南」等,惟卻難以改變飲食習慣。
因此,減肥用補充劑係被廣泛地利用於作為保健食品。關於減肥用補充劑中所調配的有效成分,可列舉如:以抑制餐後血糖上昇為目的之具有
抑制葡萄糖吸收作用的聚葡萄胺糖、以及抑制澱粉等醣類分解之桑樹萃取物等。
專利文獻1記載一種減肥用食品,其含有桑葉萃取物與聚葡萄胺糖作為有用成分。桑葉萃取物係藉由阻礙消化道中的α-葡萄糖苷酶並抑制澱粉分解為葡萄糖來抑制血中葡萄糖的上昇。已知聚葡萄胺糖係藉由黏附在消化道內黏膜而抑制醣的吸收,並且亦具有α-葡萄糖苷酶抑制作用及α-澱粉酶抑制作用。
近年來,就減肥的有用成分而言,茶花萃取物之作用係受到注目。茶花萃取物中含有茶花所特有的類黃酮苷(flavonoid glycoside),可改善脂肪代謝(專利文獻2)。
專利文獻3記載一種從茶花中萃取茶皂苷(tea saponin)的技術。此外,已知茶花中所含有的皂苷具有抗過敏活性(專利文獻4)、抑制中性脂肪吸收、保護胃黏膜、抑制糖吸收(專利文獻5)、腸蠕動亢進作用、預防或改善腸阻塞或便秘之作用、胰脂肪酶活性抑制作用、游離脂肪酸產生抑制作用(專利文獻6)及胃排空功能抑制作用(專利文獻7)等各種的藥理作用。
[先前技術文獻]
[專利文獻]
專利文獻1:日本特開2004-194635號公報
專利文獻2:日本特開2011-051950號公報
專利文獻3:日本特開2015-166326號公報
專利文獻4:日本特開2008-024654號公報
專利文獻5:日本特開2006-070018號公報
專利文獻6:日本特開2009-057365號公報
專利文獻7:日本特開2009-249374號公報
本發明者等發現含有桑葉萃取物、聚葡萄胺糖、茶花萃取物之3種成分的組成物係具有前所未有之強烈的餐後血糖值上昇抑制作用與血中三酸甘油酯上昇抑制作用,遂而完成本發明。
亦即,本發明之課題係提供一種新穎之餐後血糖值上昇抑制用組成物及血中三酸甘油酯上昇抑制用組成物。
本發明之主要構成係如下所述。
(1)一種餐後血糖值上昇抑制用及/或餐後血中三酸甘油酯上昇抑制用組成物,其含有茶花萃取物、桑葉萃取物及聚葡萄胺糖作為有效成分。
(2)如(1)所述之組成物,其中,相對於每1質量份之茶花萃取物乾燥物,含有2至4質量份之桑葉萃取物乾燥物、及1至2質量份之聚葡萄胺糖。
(3)如(1)或(2)所述之組成物,其係用於在即將攝取膳食之前飲用。
(4)一種餐後血糖值上昇抑制用及/或餐後血中三酸甘油酯上昇抑制用組成物,其含有25至500mg之茶花萃取物乾燥物、50至1000mg之桑葉萃取物乾燥物、及25至1000mg之聚葡萄胺糖。
依據本發明,提供一種新穎之餐後血糖值上昇抑制用組成物及含有該組成物的錠劑及飲食品。本發明之組成物發揮使餐後上昇之血糖值降低的作用效果。此外,對於人類亦抑制餐後的血中甘油三酸酯的上昇。因此,可用於減肥用補充劑等中。
第1圖係呈示動物試驗中的試驗動物的血中葡萄糖濃度的經時變化之曲線圖。
第2圖係呈示動物試驗中的試驗動物的血中葡萄糖濃度的△經時變化之曲線圖。
第3圖係呈示動物試驗中的試驗動物的血中葡萄糖濃度的AUC之曲線圖。
第4圖係呈示動物試驗中的試驗動物的血中葡萄糖濃度的△AUC之曲線圖。
第5圖係呈示人類臨床試驗(1)中的血糖值的經時變化之曲線圖。
第6圖係呈示人類臨床試驗(1)中的血中胰島素值的經時變化之曲線圖。
第7圖係呈示人類臨床試驗(2)中的血中三酸甘油酯(TG)值的經時變化之曲線圖。
本發明係含有茶花萃取物、桑葉萃取物及聚葡萄胺糖作為有效成分的餐後血糖值上昇抑制用組成物,以及含有該組成物之餐後血糖值上昇抑制用錠劑及飲食品的發明。
本發明中,所使用之茶花係指屬於山茶科(Theaceae)植物山茶屬(Camellia L.)之茶樹(Camellia sinensis,別名Thea sinensis)的花部,亦即,包含雌蕊、雄蕊、花瓣、花萼、苞片、花軸、花梗等所謂的花、花芽及花蕾等。
本發明中,就茶花而言,可將所採收物直接使用,或經乾燥而使用,或者是以該發明所屬技術領域中具有通常知識者所公知的方法製茶而使用。
(茶花萃取物)
本發明中的茶花萃取物,係指將上述茶花以水或水性有機溶劑萃取後再去除溶劑而得之萃取物、或者是將此進一步使用水性溶劑進行分配萃取而得之萃取物。
用以製造茶花萃取物之萃取技術,係可使用專利文獻3至7所揭示之方法。具體上係如以下之記載。
關於在製造本發明的茶花萃取物時所使用之萃取溶劑,上述水性有機溶劑係以低級醇為佳。低級醇可列舉如碳數1至4之醇類。具體上係可列
舉如:甲醇、乙醇、正丙醇、異丙醇、正丁醇、異丁醇、或三級丁醇、或是該等之混合液、或者是該等之任意比例中的含水醇等。較佳係使用水或乙醇。更佳係使用水或約80%乙醇,惟本發明中之含水乙醇的乙醇量並未特別限定為80%。
相對於萃取材料,該等萃取用溶劑係使用1至50倍(體積)左右,以2至10倍(體積)左右為佳。
另外,萃取係可在加熱時或室溫下進行,萃取溫度係可在室溫與溶劑之沸點之間任意地設定。在加熱時萃取之情形下,例如係以在50℃至萃取溶劑之沸點之溫度下,於振盪(或攪拌)下或無振盪下或回流下,將茶花的花部浸漬在上述萃取溶劑中而進行為適當。將萃取材料在振盪下浸漬時,以進行30分鐘至5小時左右為適當,在無振盪下浸漬時,以進行1小時至20天左右為適當。此外,在萃取溶劑之回流下萃取時,以加熱回流30分鐘至數小時為佳。
而且,亦可在低於50℃之溫度下浸漬並萃取,此時,係以比上述時間浸漬更長時間為佳。對於相同的材料,萃取操作可僅進行1次,惟從萃取效率之觀點來看,以重複多次(例如2至5次左右)為佳。
將固形物萃取後經過濾而得的萃取液,係藉由常法進行濃縮並將其作成萃取物。濃縮係以在減壓下進行為佳。濃縮可進行至萃取液乾燥凝固為止。
萃取物係可直接用於調製本發明之組成物,亦可作成粉末狀或經凍結乾燥之乾燥萃取物品等而使用於本發明中。作成該等固形物之方法係可採用該技術領域中之公知方法。
本發明中之茶花萃取物係包含濃縮乾固物或凍結乾燥物。另外,本發明中,可將由茶花萃取液濃縮而得之萃取物,進行單次或複數次之使用溶劑之分配萃取,亦即使用水與非水合性有機溶劑之分配萃取,而分離為有機溶劑可溶部分與水溶性部分。
非水合性有機溶劑可列舉如乙酸乙酯、正丁醇、己烷、氯仿等,其中以乙酸乙酯為佳。
亦即,可將茶花之水萃取物或含水低級醇萃取物進行濃縮而得到萃取物,將其視需要而使用乙酸乙酯與水進行分配,以得到乙酸乙酯可溶部分與水溶性部分。
此外,對於上述所得之水溶性部分,可更進一步進行使用水與非水合性有機溶劑之分配萃取,而分離為有機溶劑可溶部分與水溶性部分。
此時之非水合性有機溶劑可列舉如正丁醇、己烷、氯仿等,其中以正丁醇為佳。
亦即,上述經乙酸乙酯與水進行分配後之水溶性部分,可直接進行與正丁醇之分配,或可將該水溶性部分經濃縮而得之殘渣更進一步進行水與正丁醇之分配,以得到正丁醇可溶部分與水溶性部分。
茶花萃取物係被市售作為補充劑的原料,該市售之茶花萃取物可用於本發明之目的。如此市售之茶花萃取物可例示如「茶花乾燥萃取物(日本藥用食品研究所股份有限公司製造)」。本發明中所使用之茶花萃取物,係以在茶花萃取物中就總皂苷而言含有茶皂苷1.5質量%以上者為佳。
茶花萃取物係以作為萃取物乾燥物之形式且相對於本發明之組成物使每人每次的攝取量為25至500mg(以50至250mg為佳)之方式調配。
(桑葉萃取物)
桑葉係桑科桑屬植物之葉片,除了作為蠶之餌食以外,從古至今亦被作為茶葉使用。通常稱為桑樹之植物,係以雞桑(M.bombycis)、長果桑(M.laevigata)、毛桑(M.tiliaefolia)等為具代表性者。本發明中,桑葉萃取物可使用市售品,係由日本新藥股份有限公司、豐玉香料股份有限公司等販售。
桑葉萃取物係以熱水萃取物或含水乙醇萃取物為佳。例如為將桑葉之新鮮葉片或乾燥葉片予以切細後在熱水中萃取15分鐘以上,接著進行濃縮及乾燥處理而成為粉末狀者。此外,本發明中,桑葉萃取物不僅可為上述粉末狀物,亦可使用未經乾燥而得之濃縮液狀物、未經濃縮而得之液狀萃取物等。
桑葉萃取物係以作為萃取物乾燥物之形式且相對於本發明之組成物使每人每次的攝取量為50至1000mg(以100至500mg為佳)之方式調配。
(聚葡萄胺糖)
聚葡萄胺糖(chitosan)係多糖類之一種,意指聚-β1→4-葡萄胺糖。其係直鏈型多糖類,且為葡萄胺糖(glucosamine)之1,4-聚合物,並且是分子量為數千至數十萬的高分子物質。
本發明中所使用之聚葡萄胺糖可列舉如:由螃蟹、蝦之皮殼,昆蟲之甲殼,烏賊、菇蕈及絲狀菌等之細胞壁而得之物等。較佳者可為由螃蟹、蝦之皮殼而得者。聚葡萄胺糖係以葡萄胺糖、乙醯葡萄胺糖作為成分且溶
解於酸性之水者,平均分子量一般可為1萬以上,較佳者係平均分子量為10萬以上且旋轉黏度為20mPa‧s以上,更佳者係平均分子量為80萬以上且旋轉黏度為100mPa‧s以上。此外,聚葡萄胺糖之粒度並無特別限制,較佳為通過30網目(mesh pass)以下,更佳為通過80網目以下之微細者,聚葡萄胺糖係被市售作為減肥用食品的原料,例如可使用日本化藥食品技術公司之製品。
聚葡萄胺糖係以相對於本發明之組成物使每人每次的攝取量為25至1000mg(以50至500mg為佳)之方式調配。
在本發明之組成物中,係以使相對於每1質量份之茶花萃取物乾燥物而含有2至4質量份的桑葉萃取物乾燥物、1至2質量份之聚葡萄胺糖之方式調配。藉由採取如此的調配比例,而發揮有效的餐後血糖值上昇抑制作用。
另外,本發明人等依據動物試驗進行評定時,若使用公知的桑葉萃取物與聚葡萄胺糖的組合,則顯示現有技術中公知程度之餐後血糖值上昇抑制作用。此外,本發明者等針對已知有血糖值上昇抑制作用之茶花萃取物進行試驗時,發現在動物試驗中並不具有餐後血糖值上昇抑制作用。然而,含有茶花萃取物、桑葉萃取物、聚葡萄胺糖之3成分的組成物則顯示優異之餐後血糖值上昇抑制作用。因此,該調配有茶花萃取物、桑葉萃取物、聚葡萄胺糖之3成分的組成物發揮前所未有之強烈的餐後血糖值上昇抑制效果。
而且,本發明之組成物係可調配在食品及飲料中亦無妨,以配合進食時機而攝取為佳。
本發明之組成物可直接或經製劑化後而調配在健康食品及補充錠中。
在製劑化時,可在不妨礙本發明之組成物的目的之範圍內使用賦形劑及其它有效成分。具體而言為:環糊精、半纖維素、木質素、瓜爾膠、蒟蒻聚甘露糖、洋車前子(Isabgol)、海藻酸、瓊脂、鹿角菜膠、幾丁質、羧甲基纖維素、聚葡萄糖(polydextrose)等食物纖維及增稠劑,食用油,鈣、鐵、鈉、鋅、銅、鉀、磷、鎂、碘、錳、硒等礦物質;維生素A、維生素C、維生素D、維生素E、維生素K、菸鹼酸(niacin)、葉酸、泛酸等脂溶性或水溶性之維生素群,甘油脂肪酸酯、蔗糖脂肪酸酯、去水山梨醇脂肪酸酯、丙二醇脂肪酸酯、磷脂質、阿拉伯樹膠、黃原膠(xanthan gum)、黃蓍膠(tragacanth gum)、刺槐豆膠等乳化劑及分散劑、增量劑、賦形劑、保存劑、抗氧化劑、風味調整劑及香料、氯化鈉、麩胺酸鈉、甘胺酸、琥珀酸、乳酸鈉等呈味劑,檸檬酸、檸檬酸鈉、乙酸、己二酸、延胡索酸、蘋果酸等酸味劑,麥芽糖醇、阿斯巴甜等低卡甜味劑,著色劑等。
[實施例]
以下呈示使用本發明之組成物的試驗例,進一步說明本發明。
<1.用以確認餐後血糖值上昇抑制作用之動物試驗>
1.使用之動物
購買40隻雄性ddy小鼠,開始試驗時為8週齡,在測量體重後以使各組之間的體重無差異之方式分成5組且每組8隻。在搬入動物後,以約一
週作為適應期間,從適應期間的最後一天的傍晚左右開始禁食12小時以上。
2.投予試驗
對於小鼠,在禁食下強制性地經口投予5mL/kg之於蒸餾水中溶有受驗物質的溶液,然後,同樣強制性地經口投予2g/5m/kg之醣(蔗糖)。
3.受驗物質
受驗物質之投予群與投予量係如下所述。
(1)對照群(蒸餾水5mL/kg)
(2)聚葡萄胺糖66.6mg/kg+桑葉萃取物(圖中記載為「桑葉」)133.44mg/kg
(3)茶花萃取物(圖中記載為「茶花」)39.96mg/kg
(4)聚葡萄胺糖66.6mg/kg+桑葉萃取物133.44mg/kg+茶花萃取物39.96mg/kg
(5)陽性對照群(positive control):阿卡波糖10mg/kg
另外,作為陽性對照群而使用之阿卡波糖,已知是用以治療糖尿病的醫藥品,其會抑制碳水化合物消化時所需的消化酶,特別是由小腸分泌的α-葡萄糖苷酶及由胰臟分泌的α-澱粉酶,並抑制餐後血糖值上昇。
此外,聚葡萄胺糖、桑葉萃取物及茶花萃取物之上述調配量係經計算並設定成相當於下述表1所示的人類等效量(人類體重53kg)的3倍量。
4.餐後血糖值測定
試驗當天,在投予上述受驗物質之前,從尾靜脈採集約30μL之血液。
投予蔗糖後,在30、60、90、120、180分鐘後,與上述同樣地採集約30μL之血液。從所採集之血液得到血漿,予以凍結保存,日後再測定血漿葡萄糖濃度。
結果的統計處理,係從平均值及標準偏差進行Tukey檢定,並且以P<0.05之危險率判定是否有顯著性差異。
5.試驗結果
(1)血糖值之經時變化
根據血糖值之經時測定結果,求出血糖值經時變化及各測定時間之血糖值-受驗物質投予前之血糖值=△經時變化,各自繪圖而製作血糖變動曲線圖。呈示血糖經時變化(第1圖)、△經時變化(第2圖)。
如第1圖、第2圖所示,本發明之組成物係與醫藥品之阿卡波糖幾乎同樣地抑制血糖的上昇。有趣的是,茶花萃取物(茶花)與公知的先前技術資訊不同,幾乎未觀察到對血糖值上昇的抑制。此點在△經時變化的曲線圖中可更清楚地確認。
而且,藉由調配茶花萃取物、桑葉萃取物、聚葡萄胺糖之3成分,明顯抑制餐後血糖值上昇。
(2)糖的吸收
為了確認糖的吸收量,從經時變化的曲線圖算出AUC及△AUC,並呈示於第3圖、第4圖。亦可從AUC、△AUC得知,本發明之組成物係與醫藥品的阿卡波糖幾乎同樣地明顯抑制糖的吸收。
而且,有趣的是,茶花萃取物(茶花)係與公知的先前技術資訊不同,未抑制糖的吸收。然而,如第3圖、第4圖所示,藉由調配茶花萃取物、桑葉萃取物、聚葡萄胺糖之3成分,明顯抑制糖的吸收。
<2.人類臨床試驗(1)>
依據人類臨床試驗,測試本發明組成物的餐後血糖值上昇抑制效果。
‧試驗方法
1.受驗者
(1)選擇基準
1)年齡滿20歲以上且未滿65歲之日本人成年男女(年齡以獲得同意的日期為準)、
2)空腹時血糖值為125(mg/dL)以下者、
3)攝取負荷食品30分鐘後或60分鐘後之血糖值為140(mg/dL)以上者、
4)攝取負荷食品120分鐘後之血糖值為199(mg/dL)以下者,
以滿足上述條件之40名成年人男女作為受驗者。
並且,將40名受驗者隨機分為A群與B群(每群20名,共2群)。
2.試驗食品
(1)受驗食品:打錠成形之錠劑(CAL)
(在每次攝取量3錠中)
調配:
此外,為了製造錠劑而將以下成分調配作為賦形劑:
纖維素、澱粉、羥基丙基纖維素、二氧化矽、硬脂酸鈣、蟲膠(shellac)、未烘烤的貝殼鈣、著色料(僅為安慰劑)、磷酸氫鈣。
(2)安慰劑食品:打錠成形之錠劑(P)
僅將上述賦形劑打錠成形。
3.醣負荷
關於醣負荷,係在空腹時採集血液後將受驗食品與150mL之水一起攝取,10分鐘後,將200g之「佐藤的飯」與150mL之水在10分鐘內一起攝取。在開始攝取米飯後30分鐘、60分鐘及120分鐘時採集血液。另外,試驗係分成I期、II期,設定使受驗者攝取受驗食品及安慰劑兩者作為試驗食品之交叉試驗(隔有4天以上之空白期間)。而且,所採集之血液試料係測定血糖值及胰島素值。
‧試驗結果
第5圖係呈示血糖值之測定結果的曲線圖,第6圖係呈示胰島素之測定結果的曲線圖。
相較於攝取安慰劑(P)時,在攝取受驗食品(CAL)時,米飯負荷30分鐘後、60分鐘後之血糖值及直到120分鐘後為止之AUC為顯著性低的值。在胰島素中亦為同樣的結果。因此,可證實本發明之組成物會抑制人類的餐後血糖值上昇。
<3.人類臨床試驗(2)>
依據人類臨床試驗,測試本發明組成物的餐後血中三酸甘油酯上昇抑制效果。
‧試驗方法
與餐後血糖值上昇抑制效果之試驗同樣地進行脂質負荷試驗,測定餐後血中三酸甘油酯。另外,脂質負荷食品係調製以下組成之食品。
(1)脂質負荷食品之調製
調製將20.0g之玉米奶油湯(奶油(四葉乳業股份有限公司之不含食鹽的四葉奶油))與13.9g之豬油(雪印惠乳業股份有限公司之豬油)溶於200.0g之玉米濃湯(名古屋製酪股份有限公司之玉米奶油濃湯)中並混合而得者(總脂質量為40.0g),將此作為脂質負荷食品。
‧試驗結果
第7圖係呈示三酸甘油酯之測定結果的曲線圖。
相較於攝取安慰劑(P)時,在攝取受驗食品(CAL)時,在脂質負荷2、3、4、6小時後之血中三酸甘油酯及直到6小時後為止之AUC為顯著性低的值。
因此,可證實本發明之組成物會抑制人類的餐後血糖值上昇。
另外,臨床試驗(1)、(2)中,受驗者之健康均毫無問題。
Claims (4)
- 一種餐後血糖值上昇抑制用及/或餐後血中三酸甘油酯上昇抑制用組成物,其含有茶花萃取物、桑葉萃取物及聚葡萄胺糖作為有效成分。
- 如申請專利範圍第1項所述之組成物,其中,相對於每1質量份之茶花萃取物乾燥物,含有2至4質量份之桑葉萃取物乾燥物、及1至2質量份之聚葡萄胺糖。
- 如申請專利範圍第1或2項所述之組成物,其係用於在即將攝取膳食之前飲用。
- 一種餐後血糖值上昇抑制用及/或餐後血中三酸甘油酯上昇抑制用組成物,其含有25至500mg之茶花萃取物乾燥物、50至1000mg之桑葉萃取物乾燥物、及25至1000mg之聚葡萄胺糖。
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