TWI821168B - 誘導cd8+ t細胞的組成物及方法 - Google Patents

誘導cd8+ t細胞的組成物及方法 Download PDF

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TWI821168B
TWI821168B TW106145484A TW106145484A TWI821168B TW I821168 B TWI821168 B TW I821168B TW 106145484 A TW106145484 A TW 106145484A TW 106145484 A TW106145484 A TW 106145484A TW I821168 B TWI821168 B TW I821168B
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seq
bacterial strains
bacterial
species
present disclosure
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TW106145484A
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TW201828963A (zh
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本田賢也
田上大
服部正平
河上裕
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學校法人慶應義塾
國立大學法人東京大學
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Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3978598B1 (fr) * 2011-12-01 2024-08-28 The University of Tokyo Bactéries d'origine humaine qui induisent la prolifération ou l'accumulation de lymphocytes t régulateurs
MA41060B1 (fr) 2015-06-15 2019-11-29 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
EP3559209A4 (fr) * 2016-12-23 2021-03-10 Keio University Compositions et procédés pour l'induction de lymphocytes t cd8 +
CN111107859B (zh) 2017-06-14 2022-04-29 4D制药研究有限公司 包含细菌菌株的组合物
EP3749751A4 (fr) * 2018-02-09 2022-02-23 Keio University Compositions et procédés pour l'induction de lymphocytes t cd8+
CN110496140B (zh) * 2018-05-18 2022-05-31 瑞微（深圳）生物科技有限公司 脆弱拟杆菌或阿克曼粘细菌在制备用于预防或治疗肿瘤的药物中的应用
WO2020054728A1 (fr) * 2018-09-10 2020-03-19 国立研究開発法人理化学研究所 Composition pour inhiber l'activité de la trypsine, contenant, en tant que principe actif, une bactérie appartenant au genre paraprevotella
US20210355431A1 (en) * 2018-10-15 2021-11-18 Pharmabiome Ag Method of manufacturing a consortium of bacterial strains
MA54074A (fr) * 2018-11-02 2022-02-09 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
CA3120569A1 (fr) * 2018-11-21 2020-05-28 Chan Zuckerberg Biohub, Inc. Communautes bacteriennes intestinales synthetiques haute complexite
ES2763874B2 (es) * 2018-11-30 2020-10-13 Consejo Superior Investigacion Phascolarctobacterium faecium para su uso en la prevencion y tratamiento de la obesidad y sus comorbilidades
US20220023359A1 (en) * 2018-12-07 2022-01-27 President and Fellows of Flarvard College Identification of gut bacteria that promote an anti-tumor response to immunotherapy
EP3876964A1 (fr) 2018-12-12 2021-09-15 4D Pharma Research Limited Compositions comprenant des souches bactériennes parabacteroides pour le traitement du cancer
EP4054609A1 (fr) * 2019-11-04 2022-09-14 Vedanta Biosciences, Inc. Compositions et méthodes d'amélioration de thérapie par inhibiteur de point de contrôle immunitaire
US20220409675A1 (en) * 2019-11-22 2022-12-29 Xbiome Inc. Compositions comprising bacterial species and methods related thereto
US20230002502A1 (en) * 2019-11-26 2023-01-05 South Australian Health And Medical Research Institute Limited Methods and products for reducing side effects associated with use of immune agonist antibodies
AU2020394211A1 (en) * 2019-11-27 2022-07-14 Seres Therapeutics, Inc. Designed bacterial compositions and uses thereof
WO2021141828A1 (fr) * 2020-01-10 2021-07-15 Assembly Biosciences, Inc. Compositions comprenant des espèces bactériennes et procédés associés
JP2023513569A (ja) * 2020-02-12 2023-03-31 ウニヴェルズィテート チューリッヒ がんの治療用の細菌組成物
WO2021221110A1 (fr) * 2020-04-29 2021-11-04 学校法人慶應義塾 Petite bactérie intestinale induisant la prolifération ou l'activation de cellules th1 et/ou de cellules th17
GB202007452D0 (en) 2020-05-19 2020-07-01 Microbiotica Ltd Threrapeutic bacterial composition
WO2021237162A1 (fr) * 2020-05-21 2021-11-25 Chan Zuckerberg Biohub, Inc. Communautés bactériennes intestinales synthétiques haute complexité
EP4320221A1 (fr) 2021-04-05 2024-02-14 Vedanta Biosciences, Inc. Compositions et méthodes de traitement du cancer
KR20240114298A (ko) 2023-01-12 2024-07-23 에스엔제이 파마 인크 감염 저항성 장내 균주 및 그 용도
CN116676207B (zh) * 2023-03-14 2024-06-04 中国海洋大学 一种萨利尔斯氏拟杆菌菌株及其在降解制备硫酸软骨素寡糖及透明质酸寡糖中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014121298A2 (fr) * 2013-02-04 2014-08-07 Seres Health, Inc. Méthodes de peuplement du tractus gastro-intestinal
WO2016063263A2 (fr) * 2014-10-23 2016-04-28 Institut Gustave Roussy Procédés et produits permettant de moduler la composition du microbiote afin d'améliorer l'efficacité d'un traitement anticancéreux impliquant un inhibiteur des points de contrôle du système immunitaire
WO2016196605A1 (fr) * 2015-06-01 2016-12-08 The University Of Chicago Traitement du cancer par manipulation de la flore microbienne commensale

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3249504A (en) 1962-03-13 1966-05-03 Becton Dickinson Co Multiple unit tissue culture preparation and method of preparing same
WO2004000042A2 (fr) 2002-06-19 2003-12-31 N.V. Nutricia Procede et composition permettant de traiter ou de prevenir un catabolisme ou de stimuler un anabolisme chez un mammifere soumis au stress metabolique
CN117534755A (zh) * 2005-05-09 2024-02-09 小野药品工业株式会社 程序性死亡-1(pd-1)的人单克隆抗体及使用抗pd-1抗体来治疗癌症的方法
TW200819540A (en) * 2006-07-11 2008-05-01 Genelux Corp Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders
WO2010132479A2 (fr) 2009-05-11 2010-11-18 Cytotech Labs, Llc Méthodes de diagnostic de troubles métaboliques à l'aide de décaleurs épimétaboliques, de molécules intracellulaires multidimensionnelles ou d'influenceurs environnementaux
CA2779418C (fr) 2009-11-11 2018-03-20 Alimentary Health Limited Souche de bifidobacterium probiotique
US20130017199A1 (en) * 2009-11-24 2013-01-17 AMPLIMMUNE ,Inc. a corporation Simultaneous inhibition of pd-l1/pd-l2
EP3978598B1 (fr) 2011-12-01 2024-08-28 The University of Tokyo Bactéries d'origine humaine qui induisent la prolifération ou l'accumulation de lymphocytes t régulateurs
US8906668B2 (en) 2012-11-23 2014-12-09 Seres Health, Inc. Synergistic bacterial compositions and methods of production and use thereof
BR112016010224A2 (pt) 2013-11-05 2018-05-02 Cognate Bioservices, Inc. combinações de inibidores do ponto de verificação e produtos terapêuticos para tratar o câncer.
EP3074027A1 (fr) 2013-11-25 2016-10-05 Seres Therapeutics, Inc. Compositions bactériennes synergiques et leurs procédés de production et d'utilisation
AU2015244700B2 (en) * 2014-04-10 2020-08-27 Riken Compositions and methods for induction of Th17 cells
EP3012270A1 (fr) 2014-10-23 2016-04-27 Institut Gustave Roussy Produits pour moduler la composition microbienne afin d'améliorer l'efficacité d'un traitement du cancer avec un bloqueur de vérification immunitaire
EP3559209A4 (fr) 2016-12-23 2021-03-10 Keio University Compositions et procédés pour l'induction de lymphocytes t cd8 +
EP3749751A4 (fr) 2018-02-09 2022-02-23 Keio University Compositions et procédés pour l'induction de lymphocytes t cd8+

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014121298A2 (fr) * 2013-02-04 2014-08-07 Seres Health, Inc. Méthodes de peuplement du tractus gastro-intestinal
WO2016063263A2 (fr) * 2014-10-23 2016-04-28 Institut Gustave Roussy Procédés et produits permettant de moduler la composition du microbiote afin d'améliorer l'efficacité d'un traitement anticancéreux impliquant un inhibiteur des points de contrôle du système immunitaire
WO2016196605A1 (fr) * 2015-06-01 2016-12-08 The University Of Chicago Traitement du cancer par manipulation de la flore microbienne commensale

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