TWI804691B - 一種用於癌症、肥胖、代謝失調、及相關併發症與合併症之精胺酸消耗劑的組成物及用途 - Google Patents

一種用於癌症、肥胖、代謝失調、及相關併發症與合併症之精胺酸消耗劑的組成物及用途 Download PDF

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TWI804691B
TWI804691B TW108138739A TW108138739A TWI804691B TW I804691 B TWI804691 B TW I804691B TW 108138739 A TW108138739 A TW 108138739A TW 108138739 A TW108138739 A TW 108138739A TW I804691 B TWI804691 B TW I804691B
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seq
rharg
arginine
aforementioned
abd
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TW108138739A
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TW202112390A (zh
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潤松 梁
秀媛 沈
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香港理工大學
香港中文大學
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
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    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
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    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/03—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amidines (3.5.3)
    • C12Y305/03001—Arginase (3.5.3.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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TW108138739A 2018-05-31 2019-10-25 一種用於癌症、肥胖、代謝失調、及相關併發症與合併症之精胺酸消耗劑的組成物及用途 TWI804691B (zh)

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US201862678300P 2018-05-31 2018-05-31
PCT/CN2019/089583 WO2019228510A1 (en) 2018-05-31 2019-05-31 Composition and application of arginine-depleting agents for cancer, obesity, metabolic disorders, and related complications and comorbidities
CNPCT/CN2019/089583 2019-05-31

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TW202112390A TW202112390A (zh) 2021-04-01
TWI804691B true TWI804691B (zh) 2023-06-11

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TW112116955A TWI868683B (zh) 2018-05-31 2019-10-25 一種用於癌症、肥胖、代謝失調、及相關併發症與合併症之精胺酸消耗劑的組成物及用途

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US (1) US20200181597A1 (https=)
EP (2) EP4616911A3 (https=)
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KR (1) KR20210016434A (https=)
CN (2) CN112513099A (https=)
AU (2) AU2019275733B2 (https=)
BR (1) BR112020024227A2 (https=)
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US12508306B2 (en) 2018-04-25 2025-12-30 Washington University Compositions and methods of use thereof for treatment of metabolic diseases and related disorders
AU2019275733B2 (en) * 2018-05-31 2025-07-31 The Chinese University Of Hong Kong Composition and application of arginine-depleting agents for cancer, obesity, metabolic disorders, and related complications and comorbidities
EP3823994A4 (en) * 2018-07-19 2022-04-20 Ab Studio Inc. Novel systems for screening internalizing antibody and uses thereof
WO2020081994A1 (en) 2018-10-19 2020-04-23 Aerase, Inc. Arginine depletion therapy for treatment of gamt deficiency
KR20220082813A (ko) 2019-08-30 2022-06-17 아이글레아 바이오테라퓨틱스, 인크. 인간 재조합 아르기나아제 1의 제조 방법 및 이의 사용
US20210162028A1 (en) * 2019-12-02 2021-06-03 The Hong Kong Polytechnic University Methods for Inducing Intermittent Fasting and Modulating Autophagy
JP7520121B2 (ja) * 2019-12-18 2024-07-22 ヒルズ・ペット・ニュートリシャン・インコーポレーテッド シュウ酸カルシウム結石形成のリスクにあるコンパニオンアニマルを特定する方法、及び当該リスクを減少させるための治療と組成物
JP2023522888A (ja) * 2020-04-17 2023-06-01 バイオ－キャンサー・トリートメント・インターナショナル・リミテッド アルギナーゼを使用してウイルス感染症を処置する方法
WO2021257523A1 (en) * 2020-06-15 2021-12-23 Aeglea Biotherapeutics, Inc. Use of arginase for treatment of influenza infections
WO2022195629A1 (en) * 2021-03-18 2022-09-22 National Institute Of Pharmaceutical Education And Research (Niper) Engineered arginase constructs, method of generation and uses thereof
CN118201954A (zh) * 2021-09-20 2024-06-14 克云生物科技股份公司 精氨酸酶-胰岛素融合蛋白
CN120383669B (zh) * 2025-04-24 2025-10-28 广东医科大学 一种重组人长效白细胞介素-22结合蛋白的制备方法及应用

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EP2411040B1 (en) * 2009-03-26 2015-09-23 The Hong Kong Polytechnic University Site-directed pegylation of arginases and the use thereof as anti-cancer and anti-viral agents
US20140255377A1 (en) * 2013-03-06 2014-09-11 Vision Global Holdings Ltd. Pharmaceutical composition comprising albumin-binding arginine deiminase for cancer targeting treatment

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TWI868683B (zh) 2025-01-01
IL278993A (en) 2021-01-31
BR112020024227A2 (pt) 2021-03-16
IL278993B1 (en) 2025-10-01
US20200181597A1 (en) 2020-06-11
WO2019228510A1 (en) 2019-12-05
AU2019275733B2 (en) 2025-07-31
IL278993B2 (en) 2026-02-01
EP3802621B8 (en) 2025-10-15
TW202400634A (zh) 2024-01-01
EP4616911A2 (en) 2025-09-17
SG11202011838XA (en) 2020-12-30
CN116920081A (zh) 2023-10-24
TW202112390A (zh) 2021-04-01
JP2024116237A (ja) 2024-08-27
AU2019275733A1 (en) 2021-01-14
EP3802621A4 (en) 2022-03-30
IL323251A (en) 2025-11-01
ES3049232T3 (en) 2025-12-15
JP7576262B2 (ja) 2024-10-31
AU2025259974A1 (en) 2025-11-20
EP3802621B1 (en) 2025-07-30
CN112513099A (zh) 2021-03-16
JP2021525749A (ja) 2021-09-27
EP4616911A3 (en) 2025-12-24
EP3802621A1 (en) 2021-04-14
EP3802621C0 (en) 2025-07-30
KR20210016434A (ko) 2021-02-15

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