TWI801942B - 適用於口服的glp-1及gip受體共促效劑 - Google Patents
適用於口服的glp-1及gip受體共促效劑 Download PDFInfo
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- TWI801942B TWI801942B TW110126883A TW110126883A TWI801942B TW I801942 B TWI801942 B TW I801942B TW 110126883 A TW110126883 A TW 110126883A TW 110126883 A TW110126883 A TW 110126883A TW I801942 B TWI801942 B TW I801942B
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Classifications
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- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
Landscapes
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- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (6)
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|---|---|---|---|
| US202063055026P | 2020-07-22 | 2020-07-22 | |
| US63/055,026 | 2020-07-22 | ||
| EP20192414 | 2020-08-24 | ||
| EP20192414.9 | 2020-08-24 | ||
| US202163156988P | 2021-03-05 | 2021-03-05 | |
| US63/156,988 | 2021-03-05 |
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| TW202208411A TW202208411A (zh) | 2022-03-01 |
| TWI801942B true TWI801942B (zh) | 2023-05-11 |
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| TW110126883A TWI801942B (zh) | 2020-07-22 | 2021-07-22 | 適用於口服的glp-1及gip受體共促效劑 |
| TW111150185A TW202315883A (zh) | 2020-07-22 | 2021-07-22 | 適用於口服的glp-1及gip受體共促效劑 |
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| TW111150185A TW202315883A (zh) | 2020-07-22 | 2021-07-22 | 適用於口服的glp-1及gip受體共促效劑 |
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| Country | Link |
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| US (4) | US20220177538A1 (https=) |
| EP (1) | EP4185607A1 (https=) |
| JP (2) | JP7581385B2 (https=) |
| KR (2) | KR20230029480A (https=) |
| CN (1) | CN116157143A (https=) |
| AU (1) | AU2021312323A1 (https=) |
| BR (1) | BR112023000270A2 (https=) |
| CA (1) | CA3184717A1 (https=) |
| CL (1) | CL2023000087A1 (https=) |
| CO (1) | CO2023000097A2 (https=) |
| IL (1) | IL299701A (https=) |
| MX (1) | MX2023000303A (https=) |
| PE (1) | PE20231841A1 (https=) |
| TW (2) | TWI801942B (https=) |
| WO (1) | WO2022018186A1 (https=) |
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| MX2023000303A (es) | 2020-07-22 | 2023-02-09 | Novo Nordisk As | Coagonistas de los receptores del peptido 1 similar al glucagon (glp-1) y del polipeptido insulinotropico dependiente de glucosa (gip) adecuados para el suministro oral. |
| WO2023012263A1 (en) | 2021-08-04 | 2023-02-09 | Novo Nordisk A/S | Solid oral peptide formulations |
| TW202330584A (zh) | 2022-01-20 | 2023-08-01 | 丹麥商諾佛 儂迪克股份有限公司 | 前藥及其用途 |
| UY40349A (es) * | 2022-07-13 | 2024-01-31 | Hangzhou Zhongmeihuadong Pharmaceutical Co Ltd | Agonista dual de glp-1/gip, método de preparación y uso del mismo |
| TW202421645A (zh) | 2022-11-25 | 2024-06-01 | 丹麥商諾佛 儂迪克股份有限公司 | 如ｇｌｐ—１之肽治療劑的口服投與 |
| CN117646017A (zh) * | 2023-11-02 | 2024-03-05 | 中国人民解放军海军军医大学 | Gip/glp-1双激动剂多肽编码基因、及其重组乳酸菌和应用 |
| AR134436A1 (es) * | 2023-11-22 | 2026-01-14 | Hangzhou Zhongmeihuadong Pharmaceutical Co Ltd | Uso de un agonista dual glp-1r / gipr en la fabricación de un medicamento veterinario |
| JP7755031B2 (ja) | 2023-11-30 | 2025-10-15 | ノヴォ ノルディスク アー／エス | Ｇｌｐ－１、ｇｉｐ、およびアミリン受容体の三重作動薬 |
| WO2025133045A1 (en) | 2023-12-22 | 2025-06-26 | Novo Nordisk A/S | Fermentation process |
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| US11779648B2 (en) | 2023-10-10 |
| TW202315883A (zh) | 2023-04-16 |
| CO2023000097A2 (es) | 2023-03-27 |
| TW202208411A (zh) | 2022-03-01 |
| IL299701A (en) | 2023-03-01 |
| CL2023000087A1 (es) | 2023-07-07 |
| KR20220012840A (ko) | 2022-02-04 |
| US20220177538A1 (en) | 2022-06-09 |
| CA3184717A1 (en) | 2022-01-27 |
| JP2023534131A (ja) | 2023-08-08 |
| CN116157143A (zh) | 2023-05-23 |
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