TWI791438B - 含阿托平之水性組成物 - Google Patents

含阿托平之水性組成物 Download PDF

Info

Publication number
TWI791438B
TWI791438B TW106117194A TW106117194A TWI791438B TW I791438 B TWI791438 B TW I791438B TW 106117194 A TW106117194 A TW 106117194A TW 106117194 A TW106117194 A TW 106117194A TW I791438 B TWI791438 B TW I791438B
Authority
TW
Taiwan
Prior art keywords
aqueous composition
buffer
composition according
atropine
cellulose
Prior art date
Application number
TW106117194A
Other languages
English (en)
Chinese (zh)
Other versions
TW201808289A (zh
Inventor
長慧 陳
羅傑 布爾曼
淺田博之
高橋恭平
阪中浩二
森本隆司
藤澤豐實
Original Assignee
新加坡商新加坡保健集團私人有限公司
南洋理工大學
日商參天製藥股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=60411416&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI791438(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 新加坡商新加坡保健集團私人有限公司, 南洋理工大學, 日商參天製藥股份有限公司 filed Critical 新加坡商新加坡保健集團私人有限公司
Publication of TW201808289A publication Critical patent/TW201808289A/zh
Application granted granted Critical
Publication of TWI791438B publication Critical patent/TWI791438B/zh

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/08—Mydriatics or cycloplegics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Photolithography (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
TW106117194A 2016-05-25 2017-05-24 含阿托平之水性組成物 TWI791438B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SG10201604200P 2016-05-25
SG10201604200P 2016-05-25

Publications (2)

Publication Number Publication Date
TW201808289A TW201808289A (zh) 2018-03-16
TWI791438B true TWI791438B (zh) 2023-02-11

Family

ID=60411416

Family Applications (3)

Application Number Title Priority Date Filing Date
TW106117194A TWI791438B (zh) 2016-05-25 2017-05-24 含阿托平之水性組成物
TW112102321A TWI874894B (zh) 2016-05-25 2017-05-24 含阿托平之水性組成物
TW110141612A TWI849355B (zh) 2016-05-25 2017-05-24 含阿托平之水性組成物及其用途

Family Applications After (2)

Application Number Title Priority Date Filing Date
TW112102321A TWI874894B (zh) 2016-05-25 2017-05-24 含阿托平之水性組成物
TW110141612A TWI849355B (zh) 2016-05-25 2017-05-24 含阿托平之水性組成物及其用途

Country Status (15)

Country Link
US (2) US20210267885A1 (cg-RX-API-DMAC7.html)
EP (2) EP4112055A1 (cg-RX-API-DMAC7.html)
JP (6) JP6590860B2 (cg-RX-API-DMAC7.html)
KR (4) KR102804061B1 (cg-RX-API-DMAC7.html)
CN (3) CN109310687B (cg-RX-API-DMAC7.html)
AR (1) AR108591A1 (cg-RX-API-DMAC7.html)
CA (1) CA3023149C (cg-RX-API-DMAC7.html)
EA (1) EA201892703A1 (cg-RX-API-DMAC7.html)
ES (1) ES2929368T3 (cg-RX-API-DMAC7.html)
MY (1) MY189774A (cg-RX-API-DMAC7.html)
PH (1) PH12018502421A1 (cg-RX-API-DMAC7.html)
SG (1) SG11201809822SA (cg-RX-API-DMAC7.html)
TW (3) TWI791438B (cg-RX-API-DMAC7.html)
UA (1) UA126195C2 (cg-RX-API-DMAC7.html)
WO (1) WO2017204262A1 (cg-RX-API-DMAC7.html)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016172712A2 (en) * 2015-04-23 2016-10-27 Sydnexis, Inc. Ophthalmic composition
US9421199B2 (en) 2014-06-24 2016-08-23 Sydnexis, Inc. Ophthalmic composition
US11052094B2 (en) 2015-05-29 2021-07-06 Sydnexis, Inc. D2O stabilized pharmaceutical formulations
EP3585386A4 (en) * 2017-02-21 2020-12-30 Singapore Health Services PTE Ltd COMPOSITION AND PROCESS FOR PREVENTING OR DELAYING THE ONCE OF MYOPIA INCLUDING ATROPINE
RU2745603C1 (ru) 2017-05-11 2021-03-29 Невакар Инк. Фармацевтические композиции атропина
CN110934816B (zh) 2018-09-25 2022-04-08 沈阳兴齐眼科医院有限公司 一种提高低浓度阿托品眼用制剂稳定性的方法
CN110934869B (zh) * 2018-09-25 2023-07-04 沈阳兴齐眼药股份有限公司 一种阿托品药物组合物和药盒产品
EP3701938B8 (en) 2019-03-01 2024-02-21 Medivis S.R.L. Ophthalmic formulations based on atropine
EP4192471A4 (en) 2020-08-04 2024-07-24 Santen Pharmaceutical Co., Ltd. Agent for treating myopia, preventing myopia and/or suppressing myopia progression
TW202228706A (zh) * 2020-10-14 2022-08-01 日商參天製藥股份有限公司 穩定之醫藥組合物
PE20231656A1 (es) 2020-11-02 2023-10-17 Trethera Corp Formas cristalinas de un inhibidor de cinasa de desoxicitidina y sus usos
WO2022130337A1 (en) * 2020-12-17 2022-06-23 Sun Pharmaceutical Industries Limited An aqueous sterile solution of atropine for ophthalmic use
EP4088714A1 (en) 2021-05-10 2022-11-16 Warszawskie Zaklady Farmaceutyczne Polfa S.A. Ophthalmic pharmaceutical composition comprising atropine
EP4088713A1 (en) 2021-05-10 2022-11-16 Warszawskie Zaklady Farmaceutyczne Polfa S.A. Ophthalmic pharmaceutical composition comprising atropine
US20230120997A1 (en) * 2021-10-18 2023-04-20 Ocular Science, Inc. Compositions and methods for myopia control and orthokeratology lenses treatment
CN114129511A (zh) * 2021-12-07 2022-03-04 河南润弘制药股份有限公司 一种具有改进稳定性的硫酸阿托品注射液
CN119110721A (zh) * 2022-09-11 2024-12-10 爱尔康公司 包含苄基阿托品的水性药物组合物及其用途
JP7665073B1 (ja) 2024-04-05 2025-04-18 ロート製薬株式会社 容器に収容してなる眼科用組成物
JP7723851B1 (ja) * 2024-11-22 2025-08-14 参天製薬株式会社 アトロピン含有水性医薬組成物

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2617508B2 (ja) * 1988-02-05 1997-06-04 エーザイ株式会社 安定なジフェンヒドラミン含有水溶液
JP3166002B2 (ja) * 1997-01-27 2001-05-14 日本車輌製造株式会社 自動車の洗浄装置
US20030096831A1 (en) 2000-01-18 2003-05-22 Stone Richard A. Ocular growth and nicotinic antagonists
WO2002096418A1 (en) * 2001-05-25 2002-12-05 Valley Forge Pharmaceuticals Pirenzepine ophthalmic gel
US20070254914A1 (en) * 2006-05-01 2007-11-01 Non-Profit Organization Chang Gung Memorial Hospital Low-concentration atropine solution for preventing myopia progression and preparing method thereof
JP2007308398A (ja) * 2006-05-17 2007-11-29 Chang Gung Memorial Hospital 目薬、及びその製造方法
US20090041666A1 (en) * 2007-05-21 2009-02-12 Goldstein Lee E Ophthalmic formulations of Amyloid-beta contrast agent and methods of use thereof
CN101327216A (zh) * 2007-06-22 2008-12-24 肖正连 一种硫酸阿托品眼用即型凝胶
WO2012161655A1 (en) * 2011-05-23 2012-11-29 Singapore Health Services Pte Ltd Composition and/or method for reducing and/or preventing myopia progression comprising atropine
US20160009705A1 (en) * 2014-06-24 2016-01-14 Sydnexis, Inc. Ophthalmic composition
US9421199B2 (en) * 2014-06-24 2016-08-23 Sydnexis, Inc. Ophthalmic composition
JP2017102939A (ja) * 2016-12-26 2017-06-08 株式会社プロフィールド オーサリング装置、オーサリング方法、およびプログラム
RU2745603C1 (ru) * 2017-05-11 2021-03-29 Невакар Инк. Фармацевтические композиции атропина

Also Published As

Publication number Publication date
MY189774A (en) 2022-03-04
KR102804061B1 (ko) 2025-05-07
UA126195C2 (uk) 2022-08-31
EP3463360A1 (en) 2019-04-10
CN117205210A (zh) 2023-12-12
KR20250067951A (ko) 2025-05-15
ES2929368T3 (es) 2022-11-28
US20240307305A1 (en) 2024-09-19
KR20230141882A (ko) 2023-10-10
EP3463360A4 (en) 2020-01-29
JP2025084921A (ja) 2025-06-03
EA201892703A1 (ru) 2019-04-30
CA3023149A1 (en) 2017-11-30
CN109310687A (zh) 2019-02-05
KR20220154842A (ko) 2022-11-22
KR102580933B1 (ko) 2023-09-19
US20210267885A1 (en) 2021-09-02
JP2018021007A (ja) 2018-02-08
JP6590860B2 (ja) 2019-10-16
JP2025176149A (ja) 2025-12-03
CN109310687B (zh) 2023-10-20
KR20190013877A (ko) 2019-02-11
WO2017204262A1 (en) 2017-11-30
JP2021120404A (ja) 2021-08-19
TW201808289A (zh) 2018-03-16
CN117205209A (zh) 2023-12-12
JP2023058574A (ja) 2023-04-25
EP4112055A1 (en) 2023-01-04
TWI849355B (zh) 2024-07-21
AR108591A1 (es) 2018-09-05
JP6886502B2 (ja) 2021-06-16
JP2020007356A (ja) 2020-01-16
TW202325296A (zh) 2023-07-01
PH12018502421A1 (en) 2019-09-30
TWI874894B (zh) 2025-03-01
EP3463360B1 (en) 2022-08-31
TW202206070A (zh) 2022-02-16
SG11201809822SA (en) 2018-12-28
CA3023149C (en) 2024-07-02
JP7224390B2 (ja) 2023-02-17

Similar Documents

Publication Publication Date Title
TWI791438B (zh) 含阿托平之水性組成物
WO2020219707A1 (en) Compositions and methods for treatment of ocular conditions
JP7705326B2 (ja) 眼疾患を処置するためのオキシメタゾリン組成物および方法
TWI839364B (zh) 包含釋放一氧化氮的前列醯胺之眼用組成物
EP3600306A1 (en) Agent for preventing myopia, treating myopia, and/or preventing myopia progression comprising tiotropium as active ingredient
WO2018174145A1 (en) Agent for preventing myopia, treating myopia, and/or preventing myopia progression comprising umeclidinium as active ingredient
JP7723851B1 (ja) アトロピン含有水性医薬組成物
HK40003059A (en) Atropine-containing aqueous composition
HK40003059B (zh) 含有阿托品的水性组合物
HK40004290A (en) Atropine-containing aqueous composition
HK40004290B (en) Atropine-containing aqueous composition
EA044560B1 (ru) Водная композиция, содержащая атропин
HK40005358A (en) Eye-drop composition for lowering intraocular pressure