TWI789378B - 硫代硫酸鈉之透析中用途 - Google Patents
硫代硫酸鈉之透析中用途 Download PDFInfo
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- TWI789378B TWI789378B TW107107748A TW107107748A TWI789378B TW I789378 B TWI789378 B TW I789378B TW 107107748 A TW107107748 A TW 107107748A TW 107107748 A TW107107748 A TW 107107748A TW I789378 B TWI789378 B TW I789378B
- Authority
- TW
- Taiwan
- Prior art keywords
- thiosulfate
- dialysate
- sodium thiosulfate
- spiked
- dialysis
- Prior art date
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- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 title claims abstract description 209
- 235000019345 sodium thiosulphate Nutrition 0.000 title claims abstract description 206
- DHCDFWKWKRSZHF-UHFFFAOYSA-N sulfurothioic S-acid Chemical compound OS(O)(=O)=S DHCDFWKWKRSZHF-UHFFFAOYSA-N 0.000 claims abstract description 106
- 238000001631 haemodialysis Methods 0.000 claims abstract description 43
- 230000000322 hemodialysis Effects 0.000 claims abstract description 43
- 238000000502 dialysis Methods 0.000 claims description 131
- 239000000243 solution Substances 0.000 claims description 118
- 239000012528 membrane Substances 0.000 claims description 93
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 64
- 239000002253 acid Substances 0.000 claims description 60
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 59
- 239000007864 aqueous solution Substances 0.000 claims description 58
- 239000008280 blood Substances 0.000 claims description 44
- 210000004369 blood Anatomy 0.000 claims description 44
- 239000000203 mixture Substances 0.000 claims description 41
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 26
- 239000012141 concentrate Substances 0.000 claims description 22
- 239000003814 drug Substances 0.000 claims description 20
- 201000010099 disease Diseases 0.000 claims description 15
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- 206010020772 Hypertension Diseases 0.000 claims description 6
- 206010049418 Sudden Cardiac Death Diseases 0.000 claims description 6
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- 206010022562 Intermittent claudication Diseases 0.000 claims description 4
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- 206010040642 Sickle cell anaemia with crisis Diseases 0.000 claims description 4
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- 208000028867 ischemia Diseases 0.000 claims description 4
- 208000009304 Acute Kidney Injury Diseases 0.000 claims description 3
- 208000033626 Renal failure acute Diseases 0.000 claims description 3
- 201000011040 acute kidney failure Diseases 0.000 claims description 3
- 208000012998 acute renal failure Diseases 0.000 claims description 3
- 208000022831 chronic renal failure syndrome Diseases 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims 6
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 201000002818 limb ischemia Diseases 0.000 claims 1
- 230000035479 physiological effects, processes and functions Effects 0.000 claims 1
- VFNGKCDDZUSWLR-UHFFFAOYSA-M sulfo sulfate Chemical compound OS(=O)(=O)OS([O-])(=O)=O VFNGKCDDZUSWLR-UHFFFAOYSA-M 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
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- 238000000034 method Methods 0.000 abstract description 111
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 18
- 238000002560 therapeutic procedure Methods 0.000 description 16
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- 238000004255 ion exchange chromatography Methods 0.000 description 9
- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 8
- 238000001095 inductively coupled plasma mass spectrometry Methods 0.000 description 8
- 230000000069 prophylactic effect Effects 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- -1 thiosulfate anion Chemical class 0.000 description 8
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 7
- 241000124008 Mammalia Species 0.000 description 7
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 7
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 description 7
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- 239000011734 sodium Substances 0.000 description 7
- PODWXQQNRWNDGD-UHFFFAOYSA-L sodium thiosulfate pentahydrate Chemical compound O.O.O.O.O.[Na+].[Na+].[O-]S([S-])(=O)=O PODWXQQNRWNDGD-UHFFFAOYSA-L 0.000 description 7
- 239000002699 waste material Substances 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 6
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 6
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 6
- 229910052782 aluminium Inorganic materials 0.000 description 6
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- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 6
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- 229910052708 sodium Inorganic materials 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 238000000108 ultra-filtration Methods 0.000 description 6
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 5
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 4
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- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
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- VBIXEXWLHSRNKB-UHFFFAOYSA-N ammonium oxalate Chemical compound [NH4+].[NH4+].[O-]C(=O)C([O-])=O VBIXEXWLHSRNKB-UHFFFAOYSA-N 0.000 description 3
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| ES2992792T3 (en) | 2017-03-08 | 2024-12-18 | Hope Medical Entpr Inc D B A Hope Pharmaceuticals | Intradialytic use of sodium thiosulfate |
| MD3817751T2 (ro) | 2018-07-03 | 2025-10-31 | Fennec Pharmaceuticals Inc | Compoziții de tiosulfat de sodiu anhidru |
| US11850313B2 (en) * | 2019-12-20 | 2023-12-26 | The London Health Sciences Centre Research Inc. | Method and compositions for protecting tissue |
| WO2024092228A2 (en) * | 2022-10-28 | 2024-05-02 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Localized delivery of sodium thiosulfate nanoparticles to mitigate arterial calcification |
| CN116573782B (zh) * | 2023-04-03 | 2023-11-03 | 迁安市宏奥工贸有限公司 | 脱硫废液的处理方法 |
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| US7862530B2 (en) * | 1999-09-22 | 2011-01-04 | Advanced Renal Technologies | High citrate dialysate and uses thereof |
| US20160067280A1 (en) * | 2008-06-09 | 2016-03-10 | Anupkumar Shetty | Intradialytic administration of sodium thiosulfate |
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| CA1341151C (en) | 1985-09-10 | 2000-12-05 | Elias Klein | Osmotic agents form peritoneal dialysis |
| US5108767A (en) * | 1991-06-10 | 1992-04-28 | Abbott Laboratories | Liquid nutritional product for persons receiving renal dialysis |
| US6380163B1 (en) | 1992-12-22 | 2002-04-30 | Baxter International Inc. | Peritoneal dialysis solutions with polypeptides |
| FI98538C (fi) * | 1993-10-20 | 1997-07-10 | Enso Gutzeit Oy | Menetelmä natriumhydroksidin valmistamiseksi valkolipeästä |
| US6306836B1 (en) | 1994-01-21 | 2001-10-23 | Baxter International Inc. | Peritoneal dialysis solutions containing maltodextrins and amino acids |
| US6436969B1 (en) | 1995-09-12 | 2002-08-20 | Kansas University Medical Center Research Institute Inc. | Dialysis solutions and methods |
| CA2406081C (en) * | 2000-04-26 | 2009-12-22 | Oregon Health Sciences University | Administration of a thiol-based chemoprotectant compound |
| JP4882054B2 (ja) | 2000-09-13 | 2012-02-22 | 独立行政法人科学技術振興機構 | 腹膜透析液およびその調製法 |
| CA2537222A1 (en) | 2003-07-09 | 2005-01-27 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of nitrite salts for the treatment of cardiovascular conditions |
| WO2006001345A1 (ja) | 2004-06-23 | 2006-01-05 | Kyowa Hakko Kogyo Co., Ltd. | Ｌ－リジン・クエン酸塩結晶 |
| US20070154570A1 (en) | 2004-09-29 | 2007-07-05 | Miller Christopher C | Use of nitric oxide in the treatment and disinfection of biofilms |
| US7834065B2 (en) | 2005-01-31 | 2010-11-16 | Bmg Incorporated | Medical-use two part reactive adhesive and medical-use resin having self-degradation property |
| US8568793B2 (en) | 2009-02-11 | 2013-10-29 | Hope Medical Enterprises, Inc. | Sodium nitrite-containing pharmaceutical compositions |
| DK2451435T4 (da) | 2009-07-08 | 2022-02-28 | Hope Medical Entpr Inc D B A Hope Pharmaceuticals | Natriumthiosulfat-indeholdende farmaceutiske sammensætninger |
| WO2013023217A1 (en) | 2011-08-11 | 2013-02-14 | Board Of Regents, The University Of Texas System | Method of measuring and monitoring in vivo nitrite levels |
| AU2013212264B2 (en) | 2012-01-23 | 2017-05-18 | Santalis Pharmaceuticals Inc. | Sandalwood oil and its uses related to clostridium infections |
| JP2015516407A (ja) * | 2012-05-10 | 2015-06-11 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 異所性石灰化の治療のためのチオ硫酸ナトリウム |
| JP5486069B1 (ja) * | 2012-11-05 | 2014-05-07 | 旭 酒井 | 透析装置 |
| US20140350097A1 (en) | 2013-05-23 | 2014-11-27 | Medinox,Inc. | Treatment of hypotension associated with hemodialysis |
| WO2016094409A1 (en) * | 2014-12-09 | 2016-06-16 | Villarreal Anna | Methods and devices for female health monitoring |
| ES2992792T3 (en) | 2017-03-08 | 2024-12-18 | Hope Medical Entpr Inc D B A Hope Pharmaceuticals | Intradialytic use of sodium thiosulfate |
| IL301302B2 (en) | 2017-03-08 | 2024-09-01 | Hope Medical Entpr Inc Dba Hope Pharmaceuticals | Intradialytic use of sodium nitrite |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7862530B2 (en) * | 1999-09-22 | 2011-01-04 | Advanced Renal Technologies | High citrate dialysate and uses thereof |
| US20160067280A1 (en) * | 2008-06-09 | 2016-03-10 | Anupkumar Shetty | Intradialytic administration of sodium thiosulfate |
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