ES2992792T3 - Intradialytic use of sodium thiosulfate - Google Patents
Intradialytic use of sodium thiosulfate Download PDFInfo
- Publication number
- ES2992792T3 ES2992792T3 ES18764116T ES18764116T ES2992792T3 ES 2992792 T3 ES2992792 T3 ES 2992792T3 ES 18764116 T ES18764116 T ES 18764116T ES 18764116 T ES18764116 T ES 18764116T ES 2992792 T3 ES2992792 T3 ES 2992792T3
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- ES
- Spain
- Prior art keywords
- thiosulfate
- sodium thiosulfate
- dialysate
- enriched
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 title claims abstract description 212
- 235000019345 sodium thiosulphate Nutrition 0.000 title claims abstract description 209
- 238000000034 method Methods 0.000 claims abstract description 64
- DHCDFWKWKRSZHF-UHFFFAOYSA-N sulfurothioic S-acid Chemical compound OS(O)(=O)=S DHCDFWKWKRSZHF-UHFFFAOYSA-N 0.000 claims abstract 17
- 239000000243 solution Substances 0.000 claims description 87
- 238000000502 dialysis Methods 0.000 claims description 66
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 49
- 239000007864 aqueous solution Substances 0.000 claims description 46
- 239000012528 membrane Substances 0.000 claims description 45
- 239000002253 acid Substances 0.000 claims description 43
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 42
- 239000008280 blood Substances 0.000 claims description 31
- 210000004369 blood Anatomy 0.000 claims description 31
- 239000000203 mixture Substances 0.000 claims description 25
- 201000001320 Atherosclerosis Diseases 0.000 claims description 8
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 8
- 208000020832 chronic kidney disease Diseases 0.000 claims description 8
- 208000002815 pulmonary hypertension Diseases 0.000 claims description 8
- 208000010125 myocardial infarction Diseases 0.000 claims description 7
- 206010020772 Hypertension Diseases 0.000 claims description 6
- 206010049418 Sudden Cardiac Death Diseases 0.000 claims description 6
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- 206010002383 Angina Pectoris Diseases 0.000 claims description 4
- 208000032064 Chronic Limb-Threatening Ischemia Diseases 0.000 claims description 4
- 206010022562 Intermittent claudication Diseases 0.000 claims description 4
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- 206010040642 Sickle cell anaemia with crisis Diseases 0.000 claims description 4
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- 238000001631 haemodialysis Methods 0.000 abstract description 42
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- DHCDFWKWKRSZHF-UHFFFAOYSA-L thiosulfate(2-) Chemical compound [O-]S([S-])(=O)=O DHCDFWKWKRSZHF-UHFFFAOYSA-L 0.000 description 136
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 27
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 19
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- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 description 10
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- 239000003112 inhibitor Substances 0.000 description 10
- 229940124597 therapeutic agent Drugs 0.000 description 10
- 238000001514 detection method Methods 0.000 description 9
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- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 description 8
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- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 6
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- 229910052785 arsenic Inorganic materials 0.000 description 6
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 6
- 238000002354 inductively-coupled plasma atomic emission spectroscopy Methods 0.000 description 6
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- External Artificial Organs (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US201762468871P | 2017-03-08 | 2017-03-08 | |
| PCT/US2018/021069 WO2018165108A1 (en) | 2017-03-08 | 2018-03-06 | Intradialytic use of sodium thiosulfate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2992792T3 true ES2992792T3 (en) | 2024-12-18 |
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| ES2992792T3 (en) | 2017-03-08 | 2024-12-18 | Hope Medical Entpr Inc D B A Hope Pharmaceuticals | Intradialytic use of sodium thiosulfate |
| MD3817751T2 (ro) | 2018-07-03 | 2025-10-31 | Fennec Pharmaceuticals Inc | Compoziții de tiosulfat de sodiu anhidru |
| US11850313B2 (en) * | 2019-12-20 | 2023-12-26 | The London Health Sciences Centre Research Inc. | Method and compositions for protecting tissue |
| WO2024092228A2 (en) * | 2022-10-28 | 2024-05-02 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Localized delivery of sodium thiosulfate nanoparticles to mitigate arterial calcification |
| CN116573782B (zh) * | 2023-04-03 | 2023-11-03 | 迁安市宏奥工贸有限公司 | 脱硫废液的处理方法 |
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| CA1341151C (en) | 1985-09-10 | 2000-12-05 | Elias Klein | Osmotic agents form peritoneal dialysis |
| US5108767A (en) * | 1991-06-10 | 1992-04-28 | Abbott Laboratories | Liquid nutritional product for persons receiving renal dialysis |
| US6380163B1 (en) | 1992-12-22 | 2002-04-30 | Baxter International Inc. | Peritoneal dialysis solutions with polypeptides |
| FI98538C (fi) * | 1993-10-20 | 1997-07-10 | Enso Gutzeit Oy | Menetelmä natriumhydroksidin valmistamiseksi valkolipeästä |
| US6306836B1 (en) | 1994-01-21 | 2001-10-23 | Baxter International Inc. | Peritoneal dialysis solutions containing maltodextrins and amino acids |
| US6436969B1 (en) | 1995-09-12 | 2002-08-20 | Kansas University Medical Center Research Institute Inc. | Dialysis solutions and methods |
| CA2422850C (en) * | 1999-09-22 | 2009-03-03 | Advanced Renal Technologies | High citrate dialysate and uses thereof |
| CA2406081C (en) * | 2000-04-26 | 2009-12-22 | Oregon Health Sciences University | Administration of a thiol-based chemoprotectant compound |
| JP4882054B2 (ja) | 2000-09-13 | 2012-02-22 | 独立行政法人科学技術振興機構 | 腹膜透析液およびその調製法 |
| CA2537222A1 (en) | 2003-07-09 | 2005-01-27 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of nitrite salts for the treatment of cardiovascular conditions |
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| US20070154570A1 (en) | 2004-09-29 | 2007-07-05 | Miller Christopher C | Use of nitric oxide in the treatment and disinfection of biofilms |
| US7834065B2 (en) | 2005-01-31 | 2010-11-16 | Bmg Incorporated | Medical-use two part reactive adhesive and medical-use resin having self-degradation property |
| US20090304600A1 (en) * | 2008-06-09 | 2009-12-10 | Anupkumar Shetty | Intradialytic administration of sodium thiosulfate |
| US8568793B2 (en) | 2009-02-11 | 2013-10-29 | Hope Medical Enterprises, Inc. | Sodium nitrite-containing pharmaceutical compositions |
| DK2451435T4 (da) | 2009-07-08 | 2022-02-28 | Hope Medical Entpr Inc D B A Hope Pharmaceuticals | Natriumthiosulfat-indeholdende farmaceutiske sammensætninger |
| WO2013023217A1 (en) | 2011-08-11 | 2013-02-14 | Board Of Regents, The University Of Texas System | Method of measuring and monitoring in vivo nitrite levels |
| AU2013212264B2 (en) | 2012-01-23 | 2017-05-18 | Santalis Pharmaceuticals Inc. | Sandalwood oil and its uses related to clostridium infections |
| JP2015516407A (ja) * | 2012-05-10 | 2015-06-11 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 異所性石灰化の治療のためのチオ硫酸ナトリウム |
| JP5486069B1 (ja) * | 2012-11-05 | 2014-05-07 | 旭 酒井 | 透析装置 |
| US20140350097A1 (en) | 2013-05-23 | 2014-11-27 | Medinox,Inc. | Treatment of hypotension associated with hemodialysis |
| WO2016094409A1 (en) * | 2014-12-09 | 2016-06-16 | Villarreal Anna | Methods and devices for female health monitoring |
| ES2992792T3 (en) | 2017-03-08 | 2024-12-18 | Hope Medical Entpr Inc D B A Hope Pharmaceuticals | Intradialytic use of sodium thiosulfate |
| IL301302B2 (en) | 2017-03-08 | 2024-09-01 | Hope Medical Entpr Inc Dba Hope Pharmaceuticals | Intradialytic use of sodium nitrite |
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2018
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| NZ788158A (en) | Intradialytic use of sodium thiosulfate |