TWI783978B - Tyk2抑制劑、其用途及生產方法 - Google Patents

Tyk2抑制劑、其用途及生產方法 Download PDF

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Publication number
TWI783978B
TWI783978B TW107107562A TW107107562A TWI783978B TW I783978 B TWI783978 B TW I783978B TW 107107562 A TW107107562 A TW 107107562A TW 107107562 A TW107107562 A TW 107107562A TW I783978 B TWI783978 B TW I783978B
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Taiwan
Prior art keywords
compound
compounds
tyk2
disease
ray diffraction
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TW107107562A
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English (en)
Chinese (zh)
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TW201840559A (zh
Inventor
傑諾米 羅伯特 葛林伍德
卡格 E 瑪斯
瓊 Ｐ 羅森
尚 巴蒂斯特 亞林
大衛 皮爾森
強納森 詹姆士 洛克雷
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美商林伯士拉克許米公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
TW107107562A 2017-03-08 2018-03-07 Tyk2抑制劑、其用途及生產方法 TWI783978B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762468688P 2017-03-08 2017-03-08
US62/468,688 2017-03-08

Publications (2)

Publication Number Publication Date
TW201840559A TW201840559A (zh) 2018-11-16
TWI783978B true TWI783978B (zh) 2022-11-21

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TW107107562A TWI783978B (zh) 2017-03-08 2018-03-07 Tyk2抑制劑、其用途及生產方法
TW113147070A TW202515876A (zh) 2017-03-08 2018-03-07 Tyk2抑制劑及其用途
TW111146722A TWI868528B (zh) 2017-03-08 2018-03-07 Ｔｙｋ２抑制劑之生產方法

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TW113147070A TW202515876A (zh) 2017-03-08 2018-03-07 Tyk2抑制劑及其用途
TW111146722A TWI868528B (zh) 2017-03-08 2018-03-07 Ｔｙｋ２抑制劑之生產方法

Country Status (10)

Country Link
US (2) US10336752B2 (https=)
EP (2) EP4338802A3 (https=)
JP (3) JP7160824B2 (https=)
CN (1) CN110582501B (https=)
AR (1) AR111233A1 (https=)
AU (3) AU2018230737B2 (https=)
CA (1) CA3055209A1 (https=)
IL (1) IL269036B2 (https=)
TW (3) TWI783978B (https=)
WO (1) WO2018165240A1 (https=)

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KR102717819B1 (ko) 2017-07-28 2024-10-14 다케다 야쿠힌 고교 가부시키가이샤 Tyk2 억제제 및 이의 용도
AU2019234574A1 (en) 2018-03-12 2020-09-03 Abbvie Inc. Inhibitors of tyrosine kinase 2 mediated signaling
JP7619951B2 (ja) 2018-10-15 2025-01-22 武田薬品工業株式会社 Ｔｙｋ２阻害剤およびその使用
AU2019364336B2 (en) 2018-10-22 2023-11-16 Alumis Inc. TYK2 inhibitors and uses thereof
US20220135567A1 (en) * 2019-02-07 2022-05-05 Ventyx Biosciences, Inc. Tyk2 pseudokinase ligands
AU2020247990A1 (en) 2019-03-26 2021-11-11 Ventyx Biosciences, Inc. TYK2 pseudokinase ligands
US11357775B2 (en) 2019-04-30 2022-06-14 Celgene Corporation Combination therapies comprising apremilast and Tyk2 inhibitors
WO2020222773A1 (en) * 2019-04-30 2020-11-05 Celgene Corporation Combination therapies comprising apremilast and tyk2 inhibitors
KR102938141B1 (ko) 2019-11-08 2026-03-11 벤틱스 바이오사이언스, 인크. Tyk2 슈도키나제 리간드
IL311624A (en) * 2021-09-23 2024-05-01 Bristol Myers Squibb Co Methods for treating hair loss disorders with TYK2 inhibitors
JP2024539280A (ja) 2021-10-25 2024-10-28 カイメラ セラピューティクス， インコーポレイテッド Ｔｙｋ２分解剤およびそれらの使用
CN118974052A (zh) * 2022-03-25 2024-11-15 武田药品工业株式会社 Tyk2抑制剂的固体形式和使用方法

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Also Published As

Publication number Publication date
TW202321243A (zh) 2023-06-01
JP2020511438A (ja) 2020-04-16
US10336752B2 (en) 2019-07-02
JP7535086B2 (ja) 2024-08-15
AU2018230737A1 (en) 2019-09-19
US20190337941A1 (en) 2019-11-07
IL269036A (en) 2019-10-31
IL269036B2 (en) 2023-03-01
EP3592746A1 (en) 2020-01-15
TWI868528B (zh) 2025-01-01
EP3592746B1 (en) 2024-01-24
JP2024153877A (ja) 2024-10-29
JP7160824B2 (ja) 2022-10-25
EP4338802A3 (en) 2024-09-04
JP2022185139A (ja) 2022-12-13
WO2018165240A1 (en) 2018-09-13
US11040967B2 (en) 2021-06-22
AU2018230737B2 (en) 2022-09-22
AU2024205575A1 (en) 2024-08-22
AU2022256121A1 (en) 2022-11-17
EP4338802A2 (en) 2024-03-20
CA3055209A1 (en) 2018-09-13
AR111233A1 (es) 2019-06-19
EP3592746A4 (en) 2020-11-25
CN110582501A (zh) 2019-12-17
US20180258086A1 (en) 2018-09-13
TW202515876A (zh) 2025-04-16
CN110582501B (zh) 2022-09-23
TW201840559A (zh) 2018-11-16
IL269036B (en) 2022-11-01

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