JP7160824B2 - Tyk2阻害剤、使用およびその製造のための方法 - Google Patents

Tyk2阻害剤、使用およびその製造のための方法 Download PDF

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JP7160824B2
JP7160824B2 JP2019548301A JP2019548301A JP7160824B2 JP 7160824 B2 JP7160824 B2 JP 7160824B2 JP 2019548301 A JP2019548301 A JP 2019548301A JP 2019548301 A JP2019548301 A JP 2019548301A JP 7160824 B2 JP7160824 B2 JP 7160824B2
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JP2020511438A (ja
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ジェレミー ロバート グリーンウッド,
クレッグ イー. マッセ,
ジョン ピー. ローソン,
ジャン-バティスト アルリン,
デイビッド ピアソン,
ジョナサン ジェイムズ ラフリー,
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ニンバス ラクシュミ, インコーポレイテッド
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01Sulfonic acids
    • C07C309/02Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

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  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2019548301A 2017-03-08 2018-03-07 Tyk2阻害剤、使用およびその製造のための方法 Active JP7160824B2 (ja)

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JP2022164799A JP7535086B2 (ja) 2017-03-08 2022-10-13 Tyk2阻害剤、使用およびその製造のための方法
JP2024127741A JP2024153877A (ja) 2017-03-08 2024-08-02 Tyk2阻害剤、使用およびその製造のための方法

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US201762468688P 2017-03-08 2017-03-08
US62/468,688 2017-03-08
PCT/US2018/021265 WO2018165240A1 (en) 2017-03-08 2018-03-07 Tyk2 inhibitors, uses, and methods for production thereof

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JP2020511438A JP2020511438A (ja) 2020-04-16
JP2020511438A5 JP2020511438A5 (https=) 2021-04-15
JP7160824B2 true JP7160824B2 (ja) 2022-10-25

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JP2019548301A Active JP7160824B2 (ja) 2017-03-08 2018-03-07 Tyk2阻害剤、使用およびその製造のための方法
JP2022164799A Active JP7535086B2 (ja) 2017-03-08 2022-10-13 Tyk2阻害剤、使用およびその製造のための方法
JP2024127741A Pending JP2024153877A (ja) 2017-03-08 2024-08-02 Tyk2阻害剤、使用およびその製造のための方法

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JP2024127741A Pending JP2024153877A (ja) 2017-03-08 2024-08-02 Tyk2阻害剤、使用およびその製造のための方法

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US (2) US10336752B2 (https=)
EP (2) EP4338802A3 (https=)
JP (3) JP7160824B2 (https=)
CN (1) CN110582501B (https=)
AR (1) AR111233A1 (https=)
AU (3) AU2018230737B2 (https=)
CA (1) CA3055209A1 (https=)
IL (1) IL269036B2 (https=)
TW (3) TWI783978B (https=)
WO (1) WO2018165240A1 (https=)

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EP3262049B1 (en) 2015-02-27 2022-07-20 Nimbus Lakshmi, Inc. Tyk2 inhibitors and uses thereof
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EP3528816A4 (en) * 2016-10-21 2020-04-08 Nimbus Lakshmi, Inc. TYK2 INHIBITORS AND USES THEREOF
KR102717819B1 (ko) 2017-07-28 2024-10-14 다케다 야쿠힌 고교 가부시키가이샤 Tyk2 억제제 및 이의 용도
AU2019234574A1 (en) 2018-03-12 2020-09-03 Abbvie Inc. Inhibitors of tyrosine kinase 2 mediated signaling
JP7619951B2 (ja) 2018-10-15 2025-01-22 武田薬品工業株式会社 Tyk2阻害剤およびその使用
AU2019364336B2 (en) 2018-10-22 2023-11-16 Alumis Inc. TYK2 inhibitors and uses thereof
US20220135567A1 (en) * 2019-02-07 2022-05-05 Ventyx Biosciences, Inc. Tyk2 pseudokinase ligands
AU2020247990A1 (en) 2019-03-26 2021-11-11 Ventyx Biosciences, Inc. TYK2 pseudokinase ligands
US11357775B2 (en) 2019-04-30 2022-06-14 Celgene Corporation Combination therapies comprising apremilast and Tyk2 inhibitors
WO2020222773A1 (en) * 2019-04-30 2020-11-05 Celgene Corporation Combination therapies comprising apremilast and tyk2 inhibitors
KR102938141B1 (ko) 2019-11-08 2026-03-11 벤틱스 바이오사이언스, 인크. Tyk2 슈도키나제 리간드
IL311624A (en) * 2021-09-23 2024-05-01 Bristol Myers Squibb Co Methods for treating hair loss disorders with TYK2 inhibitors
JP2024539280A (ja) 2021-10-25 2024-10-28 カイメラ セラピューティクス, インコーポレイテッド Tyk2分解剤およびそれらの使用
CN118974052A (zh) * 2022-03-25 2024-11-15 武田药品工业株式会社 Tyk2抑制剂的固体形式和使用方法

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TW202321243A (zh) 2023-06-01
JP2020511438A (ja) 2020-04-16
US10336752B2 (en) 2019-07-02
JP7535086B2 (ja) 2024-08-15
AU2018230737A1 (en) 2019-09-19
US20190337941A1 (en) 2019-11-07
IL269036A (en) 2019-10-31
IL269036B2 (en) 2023-03-01
EP3592746A1 (en) 2020-01-15
TWI868528B (zh) 2025-01-01
EP3592746B1 (en) 2024-01-24
JP2024153877A (ja) 2024-10-29
EP4338802A3 (en) 2024-09-04
JP2022185139A (ja) 2022-12-13
WO2018165240A1 (en) 2018-09-13
US11040967B2 (en) 2021-06-22
AU2018230737B2 (en) 2022-09-22
AU2024205575A1 (en) 2024-08-22
AU2022256121A1 (en) 2022-11-17
EP4338802A2 (en) 2024-03-20
TWI783978B (zh) 2022-11-21
CA3055209A1 (en) 2018-09-13
AR111233A1 (es) 2019-06-19
EP3592746A4 (en) 2020-11-25
CN110582501A (zh) 2019-12-17
US20180258086A1 (en) 2018-09-13
TW202515876A (zh) 2025-04-16
CN110582501B (zh) 2022-09-23
TW201840559A (zh) 2018-11-16
IL269036B (en) 2022-11-01

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