TWI778985B - 抗chikv抗體及其用途 - Google Patents

抗chikv抗體及其用途 Download PDF

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Publication number
TWI778985B
TWI778985B TW106135643A TW106135643A TWI778985B TW I778985 B TWI778985 B TW I778985B TW 106135643 A TW106135643 A TW 106135643A TW 106135643 A TW106135643 A TW 106135643A TW I778985 B TWI778985 B TW I778985B
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TW
Taiwan
Prior art keywords
seq
sequence
antibody
amino acid
chikv
Prior art date
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TW106135643A
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English (en)
Chinese (zh)
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TW201827461A (zh
Inventor
卡拉 卡特
桑德里納 勒莫因
瑪莉 曼德隆
朴晟惠
華偉 邱
強納森 羅素布雷特
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法商賽諾菲公司
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Publication of TW201827461A publication Critical patent/TW201827461A/zh
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Publication of TWI778985B publication Critical patent/TWI778985B/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/116—Togaviridae (F); Matonaviridae (F); Flaviviridae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW106135643A 2016-10-20 2017-10-18 抗chikv抗體及其用途 TWI778985B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16306374 2016-10-20
EP16306374.6 2016-10-20
??16306374.6 2016-10-20

Publications (2)

Publication Number Publication Date
TW201827461A TW201827461A (zh) 2018-08-01
TWI778985B true TWI778985B (zh) 2022-10-01

Family

ID=57590434

Family Applications (2)

Application Number Title Priority Date Filing Date
TW106135643A TWI778985B (zh) 2016-10-20 2017-10-18 抗chikv抗體及其用途
TW111134308A TW202300515A (zh) 2016-10-20 2017-10-18 抗ｃｈｉｋｖ抗體及其用途

Family Applications After (1)

Application Number Title Priority Date Filing Date
TW111134308A TW202300515A (zh) 2016-10-20 2017-10-18 抗ｃｈｉｋｖ抗體及其用途

Country Status (12)

Country Link
US (3) US11286295B2 (https=)
EP (1) EP3529271A1 (https=)
JP (3) JP7181193B6 (https=)
CN (2) CN110088131B (https=)
AR (1) AR109857A1 (https=)
CA (1) CA3040842A1 (https=)
EA (1) EA201990988A1 (https=)
IL (2) IL310834A (https=)
MA (1) MA46562A (https=)
TW (2) TWI778985B (https=)
UY (1) UY37449A (https=)
WO (1) WO2018073387A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA41517A (fr) * 2015-04-14 2017-12-19 Univ Vanderbilt Neutralisation du virus du chikungunya à médiation par des anticorps
US11286295B2 (en) 2016-10-20 2022-03-29 Sanofi Anti-CHIKV monoclonal antibodies directed against the E2 structural protein
EP3735589A2 (en) 2018-01-05 2020-11-11 Vanderbilt University Antibody-mediated neutralization of chikungunya virus
KR102201261B1 (ko) * 2019-05-15 2021-01-11 한국생명공학연구원 치쿤구니야 바이러스에 특이적인 단일클론 항체 및 이의 용도
CN114656554B (zh) * 2022-03-07 2023-05-23 中山大学 基孔肯雅热病毒e2蛋白的纳米抗体及其应用
CN118956771A (zh) * 2024-04-24 2024-11-15 华南农业大学 一种杂交瘤细胞株、基孔肯雅病毒单克隆抗体及其制备方法与应用
KR102830571B1 (ko) * 2024-12-20 2025-07-09 대한민국(질병관리청 국립보건연구원장) 치쿤구니아 바이러스 외피 재조합 단백질을 포함하는 치쿤구니아열 백신 조성물
CN119841940B (zh) * 2025-03-19 2025-06-20 中国人民解放军军事科学院军事医学研究院 一种抗基孔肯雅病毒e蛋白的纳米抗体n033及其应用

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Also Published As

Publication number Publication date
CN110088131B (zh) 2022-12-06
IL266082B1 (en) 2024-03-01
MA46562A (fr) 2019-08-28
IL266082B2 (en) 2024-07-01
IL310834A (en) 2024-04-01
JP2023015301A (ja) 2023-01-31
TW202300515A (zh) 2023-01-01
CN115873106A (zh) 2023-03-31
US20220275063A1 (en) 2022-09-01
JP2025038079A (ja) 2025-03-18
US11286295B2 (en) 2022-03-29
UY37449A (es) 2018-05-31
CN110088131A (zh) 2019-08-02
TW201827461A (zh) 2018-08-01
US20260001940A1 (en) 2026-01-01
CA3040842A1 (en) 2018-04-26
AR109857A1 (es) 2019-01-30
IL266082A (en) 2019-06-30
WO2018073387A1 (en) 2018-04-26
JP7181193B6 (ja) 2022-12-13
JP2019534001A (ja) 2019-11-28
US12227560B2 (en) 2025-02-18
EA201990988A1 (ru) 2019-09-30
JP7664212B2 (ja) 2025-04-17
US20180127487A1 (en) 2018-05-10
EP3529271A1 (en) 2019-08-28
JP7181193B2 (ja) 2022-11-30

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