TWI776835B - 胺基-三唑并吡啶化合物及其在治療癌症中之用途 - Google Patents

胺基-三唑并吡啶化合物及其在治療癌症中之用途 Download PDF

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TWI776835B
TWI776835B TW106144799A TW106144799A TWI776835B TW I776835 B TWI776835 B TW I776835B TW 106144799 A TW106144799 A TW 106144799A TW 106144799 A TW106144799 A TW 106144799A TW I776835 B TWI776835 B TW I776835B
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methyl
compound
cancer
dihydro
purin
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TW106144799A
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TW201837045A (zh
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慕里斯 雷蒙 佛斯裘爾 芬萊
佛瑞德克 沃夫 高德柏格
艾提拉 寬 凗 丁
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瑞典商阿斯特捷利康公司
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/502Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • A61K31/522Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
TW106144799A 2016-12-20 2017-12-20 胺基-三唑并吡啶化合物及其在治療癌症中之用途 TWI776835B (zh)

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US62/436,619 2016-12-20

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MY183036A (en) 2021-02-08
US11136340B2 (en) 2021-10-05
DOP2019000168A (es) 2019-07-15
SMT202100225T1 (it) 2021-05-07
SI3558997T1 (sl) 2021-07-30
US20220041625A1 (en) 2022-02-10
JP2020504107A (ja) 2020-02-06
CA3046339C (en) 2022-02-22
PE20191474A1 (es) 2019-10-16
CA3046339A1 (en) 2018-06-28
US20240124492A1 (en) 2024-04-18
MX2019007189A (es) 2019-10-09
TW201837045A (zh) 2018-10-16
BR112019012217A2 (pt) 2019-11-12
PT3558997T (pt) 2021-04-13
ES2867274T3 (es) 2021-10-20
PL3558997T3 (pl) 2021-07-19
AR110400A1 (es) 2019-03-27
NI201900062A (es) 2020-07-22
US11746118B2 (en) 2023-09-05
US10407446B2 (en) 2019-09-10
CR20190301A (es) 2019-09-04
EP3558997B1 (en) 2021-01-27
PH12019501350A1 (en) 2020-01-20
CN110177791A (zh) 2019-08-27
DK3558997T3 (da) 2021-04-19
JP6883653B2 (ja) 2021-06-09
JOP20190151A1 (ar) 2019-06-20
UA123032C2 (uk) 2021-02-03
KR20190092573A (ko) 2019-08-07
MA47079B1 (fr) 2021-05-31
PH12019501350B1 (en) 2024-02-23
AU2017384388A1 (en) 2019-07-25
NZ755222A (en) 2022-07-01
KR102220971B1 (ko) 2021-02-25
MX390535B (es) 2025-03-20
CN110177791B (zh) 2022-07-12
HUE054548T2 (hu) 2021-09-28
CO2019007810A2 (es) 2019-10-09
IL267158B (en) 2020-10-29
JOP20190151B1 (ar) 2023-09-17
HRP20210548T1 (hr) 2021-05-14
EA037745B1 (ru) 2021-05-18
IL267158A (en) 2019-08-29
MA47079A (fr) 2019-10-30
EA201991399A1 (ru) 2020-01-22
AU2017384388B2 (en) 2020-09-17
US20180194782A1 (en) 2018-07-12
CL2019001714A1 (es) 2019-09-06
EP3558997A1 (en) 2019-10-30
ECSP19044159A (es) 2019-06-30
CY1124239T1 (el) 2022-07-22
RS61701B1 (sr) 2021-05-31
ZA201904695B (en) 2021-05-26
US20200048281A1 (en) 2020-02-13
WO2018114999A1 (en) 2018-06-28
LT3558997T (lt) 2021-04-26
BR112019012217B1 (pt) 2021-08-10

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