TWI765917B - 用於治療眼疾的方法 - Google Patents

用於治療眼疾的方法 Download PDF

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Publication number
TWI765917B
TWI765917B TW106133818A TW106133818A TWI765917B TW I765917 B TWI765917 B TW I765917B TW 106133818 A TW106133818 A TW 106133818A TW 106133818 A TW106133818 A TW 106133818A TW I765917 B TWI765917 B TW I765917B
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TW
Taiwan
Prior art keywords
eye
diabetic
bmx
compound
cells
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TW106133818A
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English (en)
Chinese (zh)
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TW201828933A (zh
Inventor
春億 邱
陳嘉南
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彥臣生技藥品股份有限公司
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Publication of TW201828933A publication Critical patent/TW201828933A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW106133818A 2016-09-29 2017-09-29 用於治療眼疾的方法 TWI765917B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662401725P 2016-09-29 2016-09-29
US62/401,725 2016-09-29

Publications (2)

Publication Number Publication Date
TW201828933A TW201828933A (zh) 2018-08-16
TWI765917B true TWI765917B (zh) 2022-06-01

Family

ID=61688114

Family Applications (1)

Application Number Title Priority Date Filing Date
TW106133818A TWI765917B (zh) 2016-09-29 2017-09-29 用於治療眼疾的方法

Country Status (9)

Country Link
US (1) US11045435B2 (https=)
EP (1) EP3518913B1 (https=)
JP (3) JP2019531296A (https=)
KR (1) KR102341446B1 (https=)
CN (1) CN109789115A (https=)
CA (1) CA3038845C (https=)
MY (1) MY198731A (https=)
TW (1) TWI765917B (https=)
WO (1) WO2018059543A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110585196B (zh) * 2018-06-13 2022-11-04 郭涛 一种治疗及预防眼科疾病的药物及其应用
KR20240016352A (ko) * 2021-05-28 2024-02-06 노벨와이즈 파마슈티칼 코포레이션 약물-내성 암을 치료하기 위한 조성물 및 방법

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100256401A1 (en) * 2009-04-03 2010-10-07 Naturewise Biotech & Medicals Corporation Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006512318A (ja) * 2002-11-12 2006-04-13 アルコン，インコーポレイテッド 眼の血管新生もしくは水腫状の疾患および障害を処置するためのヒストンデアセチラーゼインヒビター
US20050074497A1 (en) * 2003-04-09 2005-04-07 Schultz Clyde L. Hydrogels used to deliver medicaments to the eye for the treatment of posterior segment diseases
JP4873904B2 (ja) * 2005-08-22 2012-02-08 国立大学法人弘前大学 眼血管血流障害改善剤
EP2135620A4 (en) 2007-03-28 2010-12-29 Santen Pharmaceutical Co Ltd AGAINST OKULAR HYPOTONIA CONNECTED TO HISTONE DEACETYLASE INHIBITION AS AN ACTIVE SUBSTANCE
CA2630174A1 (en) * 2007-05-02 2008-11-02 Mitchell Alan Winnik Loading quantum dots into thermo-responsive microgels by reversible transfer from organic solvents to water
US20110014294A1 (en) 2008-03-03 2011-01-20 Pharmalight Inc. Stimulation of ocular retrobulbar blood flow using ocular irritants
EP2346827B1 (en) * 2008-08-27 2013-11-13 Leo Pharma A/S Pyridine derivatives as vegfr-2 receptor and protein tyrosine kinase inhibitors
ES2473792T3 (es) * 2009-04-03 2014-07-07 Naturewise Biotech & Medicals Corporation Compuestos cin�micos y derivados de los mismos para la inhibición de la histona desacetilasa
EP2277387B1 (en) * 2009-07-22 2016-10-19 NatureWise Biotech & Medicals Corporation New use of histone deacetylase inhibitors in changing mrjp3 protein in royal jelly
CN104080467B (zh) * 2011-05-09 2020-09-15 急速制药公司 整联蛋白受体拮抗剂及其使用方法
CA2946086A1 (en) * 2014-04-17 2015-10-22 Teraclon Idf, S.L. Recombinant monoclonal antibodies vnar neutralizing the vascular endothelial growth factor (vegf)
US9956254B2 (en) * 2015-02-26 2018-05-01 Naturewise Biotech & Medicals Corporation Extract of taiwanese propolis for treating ocular diseases

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100256401A1 (en) * 2009-04-03 2010-10-07 Naturewise Biotech & Medicals Corporation Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Expert Opinion on Investigational Drugs, Volume 18, 2009 - Issue 5 Pages 637-646 Published online: 24 Apr 2009 *
PLoS ONE 8(11): e81592. doi:10.1371/journal.pone.0081592, Nov 27, 2013; *

Also Published As

Publication number Publication date
JP2019531296A (ja) 2019-10-31
KR20190045304A (ko) 2019-05-02
JP2021138710A (ja) 2021-09-16
CA3038845A1 (en) 2018-04-05
CA3038845C (en) 2022-04-19
US20180085329A1 (en) 2018-03-29
EP3518913A1 (en) 2019-08-07
TW201828933A (zh) 2018-08-16
EP3518913C0 (en) 2025-07-23
WO2018059543A1 (en) 2018-04-05
EP3518913A4 (en) 2020-05-27
US11045435B2 (en) 2021-06-29
CN109789115A (zh) 2019-05-21
MY198731A (en) 2023-09-20
KR102341446B1 (ko) 2021-12-21
JP2023116748A (ja) 2023-08-22
EP3518913B1 (en) 2025-07-23

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