TWI761476B - 尼拉帕尼(niraparib)組合物 - Google Patents

尼拉帕尼(niraparib)組合物 Download PDF

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Publication number
TWI761476B
TWI761476B TW107110575A TW107110575A TWI761476B TW I761476 B TWI761476 B TW I761476B TW 107110575 A TW107110575 A TW 107110575A TW 107110575 A TW107110575 A TW 107110575A TW I761476 B TWI761476 B TW I761476B
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TW
Taiwan
Prior art keywords
composition
phenyl
indazole
carboxamide
piperidin
Prior art date
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TW107110575A
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English (en)
Chinese (zh)
Other versions
TW201840315A (zh
Inventor
喬治 吳
約翰 查伯
阿琳 Ｅ 麥考恩
珍妮佛 Ｒ 佛利
Original Assignee
美商提薩羅有限公司
美商默沙東藥廠
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=63676949&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI761476(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 美商提薩羅有限公司, 美商默沙東藥廠 filed Critical 美商提薩羅有限公司
Publication of TW201840315A publication Critical patent/TW201840315A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
TW107110575A 2017-03-27 2018-03-27 尼拉帕尼(niraparib)組合物 TWI761476B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762477411P 2017-03-27 2017-03-27
US62/477,411 2017-03-27

Publications (2)

Publication Number Publication Date
TW201840315A TW201840315A (zh) 2018-11-16
TWI761476B true TWI761476B (zh) 2022-04-21

Family

ID=63676949

Family Applications (1)

Application Number Title Priority Date Filing Date
TW107110575A TWI761476B (zh) 2017-03-27 2018-03-27 尼拉帕尼(niraparib)組合物

Country Status (14)

Country Link
US (3) US11091459B2 (enExample)
EP (1) EP3600314A1 (enExample)
JP (1) JP2020512350A (enExample)
KR (1) KR20200014736A (enExample)
CN (1) CN110944638A (enExample)
AU (2) AU2018246214B2 (enExample)
BR (1) BR112019020211A2 (enExample)
CA (1) CA3058375C (enExample)
EA (1) EA201992177A1 (enExample)
IL (1) IL269630A (enExample)
MX (1) MX2019011496A (enExample)
SG (1) SG11201909011PA (enExample)
TW (1) TWI761476B (enExample)
WO (1) WO2018183354A1 (enExample)

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DK3478286T3 (da) 2016-06-29 2024-01-29 Tesaro Inc Fremgangsmåder til behandling af ovariecancer
CN110944638A (zh) 2017-03-27 2020-03-31 特沙诺有限公司 尼拉帕尼组合物
CN110753684A (zh) 2017-04-24 2020-02-04 特沙诺有限公司 尼拉帕利的制造方法
TWI879716B (zh) 2017-05-09 2025-04-11 美商提薩羅有限公司 治療癌症的組合療法
CN110913911A (zh) 2017-05-18 2020-03-24 特沙诺有限公司 用于治疗癌症的组合疗法
BR112020006039A2 (pt) 2017-09-26 2020-10-06 Tesaro, Inc. formulações de niraparibe
SG11202002862RA (en) 2017-09-30 2020-04-29 Tesaro Inc Combination therapies for treating cancer
KR20200067164A (ko) 2017-10-06 2020-06-11 테사로, 인코포레이티드 조합 요법 및 그의 용도
US20210030735A1 (en) 2018-02-05 2021-02-04 Tesaro, Inc. Pediatric niraparib formulations and pediatric treatment methods
US12297184B2 (en) 2018-10-03 2025-05-13 Tesaro, Inc. Niraparib salts
WO2020072860A1 (en) 2018-10-05 2020-04-09 Johnson Matthey Public Limited Company Niraparib solid state form
CA3087392A1 (en) 2019-07-16 2021-01-16 Apotex Inc. Crystalline forms of niraparib tosylate
CA3177137A1 (en) 2020-05-08 2021-11-11 Janssen Pharmaceutica Nv Treatments of prostate cancer with combinations of abiraterone acetate and niraparib
US20240325369A1 (en) 2021-07-19 2024-10-03 Janssen Pharmaceutica Nv Treatment of metastatic castration-resistant prostate cancer with niraparib
US20250352534A1 (en) 2022-02-15 2025-11-20 Tesaro, Inc. Use of Niraparib for the Treatment of Brain Cancer
WO2023201338A1 (en) 2022-04-15 2023-10-19 Ideaya Biosciences, Inc. Combination therapy comprising a mat2a inhibitor and a parp inhibitor
JP2025521156A (ja) 2022-06-01 2025-07-08 イデアヤ、バイオサイエンシズ、インコーポレイテッド Ｄｎａポリメラーゼシータ阻害剤としてのチアジアゾリル誘導体およびその使用
WO2024238587A1 (en) 2023-05-17 2024-11-21 Tesaro, Inc. Novel use of an inhibior of the a poly-adp ribose polymerase (parp) in the treatment of cancer

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CN110753684A (zh) 2017-04-24 2020-02-04 特沙诺有限公司 尼拉帕利的制造方法
TWI879716B (zh) 2017-05-09 2025-04-11 美商提薩羅有限公司 治療癌症的組合療法
CN110913911A (zh) 2017-05-18 2020-03-24 特沙诺有限公司 用于治疗癌症的组合疗法
CN108530425A (zh) 2017-05-27 2018-09-14 广州科锐特生物科技有限公司 一种尼拉帕尼对甲苯磺酸盐水合物晶型及其制备方法
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KR20200067164A (ko) 2017-10-06 2020-06-11 테사로, 인코포레이티드 조합 요법 및 그의 용도
CN111801117A (zh) 2017-12-27 2020-10-20 特沙诺有限公司 治疗癌症的方法
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US12297184B2 (en) * 2018-10-03 2025-05-13 Tesaro, Inc. Niraparib salts
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US20100286157A1 (en) * 2007-10-17 2010-11-11 Kudos Pharmaceuticals Limited 4- [3- (4-cyclopropanecarbonyl-piperazine-i-carbonyl) -4 -fluoro-benzyl] -2h-phthalaz in-1-one
CN106496187A (zh) * 2016-09-14 2017-03-15 陕西科技大学 一种制备PARP抑制剂Niraparib的合成方法

Also Published As

Publication number Publication date
WO2018183354A1 (en) 2018-10-04
CA3058375A1 (en) 2018-10-04
TW201840315A (zh) 2018-11-16
US20210403448A1 (en) 2021-12-30
SG11201909011PA (en) 2019-10-30
MX2019011496A (es) 2020-01-23
EP3600314A1 (en) 2020-02-05
US20230416223A1 (en) 2023-12-28
US11673877B2 (en) 2023-06-13
IL269630A (en) 2019-11-28
JP2020512350A (ja) 2020-04-23
AU2018246214A1 (en) 2019-11-07
AU2021245223A1 (en) 2021-11-04
CA3058375C (en) 2025-05-06
AU2018246214B2 (en) 2021-07-08
KR20200014736A (ko) 2020-02-11
US11091459B2 (en) 2021-08-17
BR112019020211A2 (pt) 2020-04-22
EA201992177A1 (ru) 2020-02-25
US20200017462A1 (en) 2020-01-16
CN110944638A (zh) 2020-03-31

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