TWI757229B - 用於治療微生物感染的化合物以及該化合物的用途 - Google Patents

用於治療微生物感染的化合物以及該化合物的用途 Download PDF

Info

Publication number
TWI757229B
TWI757229B TW104139459A TW104139459A TWI757229B TW I757229 B TWI757229 B TW I757229B TW 104139459 A TW104139459 A TW 104139459A TW 104139459 A TW104139459 A TW 104139459A TW I757229 B TWI757229 B TW I757229B
Authority
TW
Taiwan
Prior art keywords
group
alkyl
nitrogen
compound
carbon
Prior art date
Application number
TW104139459A
Other languages
English (en)
Chinese (zh)
Other versions
TW201625664A (zh
Inventor
布朗潘美拉
道森麥克
西莫諾維克蒙娜
布克斯史帝芬
杜波奇伊斯特
史坦威史蒂芬詹姆斯
威爾森安托內特
摩斯史蒂芬弗雷德里克
Original Assignee
美商斯佩羅治療學股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1421020.7A external-priority patent/GB201421020D0/en
Priority claimed from GBGB1516059.1A external-priority patent/GB201516059D0/en
Application filed by 美商斯佩羅治療學股份有限公司 filed Critical 美商斯佩羅治療學股份有限公司
Publication of TW201625664A publication Critical patent/TW201625664A/zh
Application granted granted Critical
Publication of TWI757229B publication Critical patent/TWI757229B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW104139459A 2014-11-26 2015-11-26 用於治療微生物感染的化合物以及該化合物的用途 TWI757229B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB1421020.7 2014-11-26
GBGB1421020.7A GB201421020D0 (en) 2014-11-26 2014-11-26 Compounds
GB1516059.1 2015-09-10
GBGB1516059.1A GB201516059D0 (en) 2015-09-10 2015-09-10 Compounds

Publications (2)

Publication Number Publication Date
TW201625664A TW201625664A (zh) 2016-07-16
TWI757229B true TWI757229B (zh) 2022-03-11

Family

ID=54705181

Family Applications (1)

Application Number Title Priority Date Filing Date
TW104139459A TWI757229B (zh) 2014-11-26 2015-11-26 用於治療微生物感染的化合物以及該化合物的用途

Country Status (8)

Country Link
US (2) US12146004B2 (cg-RX-API-DMAC7.html)
EP (1) EP3224273A1 (cg-RX-API-DMAC7.html)
JP (1) JP7349773B2 (cg-RX-API-DMAC7.html)
CN (1) CN107108699A (cg-RX-API-DMAC7.html)
AU (1) AU2015352440B2 (cg-RX-API-DMAC7.html)
CA (1) CA2968902C (cg-RX-API-DMAC7.html)
TW (1) TWI757229B (cg-RX-API-DMAC7.html)
WO (1) WO2016083531A1 (cg-RX-API-DMAC7.html)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107108699A (zh) * 2014-11-26 2017-08-29 新药物许可控股有限公司 化合物
WO2018006063A1 (en) * 2016-07-01 2018-01-04 Cidara Therapeutics, Inc. Compositions and methods for the treatment of bacterial infections
US20190315806A1 (en) * 2016-12-16 2019-10-17 Institute Of Medicinal Biotechnology, Chinese Academy Of Medical Sciences Polymyxin derivative, preparation method and application thereof
JP2021501783A (ja) * 2017-11-02 2021-01-21 ザ ユニバーシティー オブ クイーンズランド ペプチド抗生物質
LT3810633T (lt) 2018-06-25 2024-01-10 Spero Therapeutics, Inc. Junginiai
CN111690040A (zh) * 2019-03-12 2020-09-22 上海来益生物药物研究开发中心有限责任公司 多粘菌素衍生物、其制备方法和应用
CN115298198A (zh) 2020-01-21 2022-11-04 上海盟科药业股份有限公司 用于肾相关癌症靶向治疗的新型化合物和组合物
CN111559992B (zh) * 2020-05-29 2022-04-08 华中科技大学 一种2-芳基-γ-氨基丁酸衍生物的制备方法
TW202233649A (zh) 2020-11-06 2022-09-01 美商斯佩羅治療學股份有限公司 化合物
WO2022206826A1 (zh) * 2021-03-31 2022-10-06 江苏奥赛康药业有限公司 一种多粘菌素衍生物的硫酸盐及其药物组合物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090215677A1 (en) * 2008-02-08 2009-08-27 Martti Sakari Vaara Polymyxin derivatives and uses thereof
CN103946233A (zh) * 2011-11-18 2014-07-23 诺瓦克塔生物系统有限公司 多黏菌素衍生物

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2128617A (en) 1982-10-06 1984-05-02 Martti Vaara Polypeptides for use in antibacterial therapy
AU7753787A (en) 1986-08-06 1988-02-24 Jean-Luc Fauchere Production of covalent-linked conjugates from an antibiotic and a non-toxic derivative of polymyxine b
US20010021697A1 (en) 1987-09-14 2001-09-13 Henning Lowenstein Methods and compositions for the treatment of mammalian infections employing medicaments comprising hymenoptera venom, proteinageous or polypeptide components thereof, or analogues of such proteinaceous or polypeptide components
TW274552B (cg-RX-API-DMAC7.html) 1992-05-26 1996-04-21 Hoechst Ag
US5767068A (en) 1997-02-13 1998-06-16 Pathogenesis Corporation Pure biologically active colistin, its components and a colistin formulation for treatment of pulmonary infections
EP1667648A2 (en) 2003-09-30 2006-06-14 Kohi Corporation Compositions and methods for treating burns
US20060004185A1 (en) 2004-07-01 2006-01-05 Leese Richard A Peptide antibiotics and peptide intermediates for their prepartion
US7807637B2 (en) * 2006-08-11 2010-10-05 Northern Antibiotics Oy Polymyxin derivatives and uses thereof
SI2057185T1 (sl) 2006-08-11 2016-10-28 Northern Antibiotics Oy Derivati polimiksina in njihove uporabe
FI20085469A0 (fi) 2008-02-08 2008-05-16 Northern Antibiotics Oy Polymyksiinijohdannaiset, joissa on lyhyt rasvahappohäntä, ja niiden käyttöjä
US8193148B2 (en) 2008-02-08 2012-06-05 Northern Antibiotics Ltd. Short fatty acid tail polymyxin derivatives and uses thereof
ES2334547B1 (es) 2008-09-10 2010-12-03 Universidad De Barcelona Compuestos peptidicos antibacterianos.
WO2010075416A1 (en) 2008-12-23 2010-07-01 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
CN101851270A (zh) 2009-04-03 2010-10-06 梁浩 一种多粘菌素衍生物及其制备方法
WO2010130007A1 (en) * 2009-05-14 2010-11-18 Monash University Antimicrobial compounds
US8415307B1 (en) 2010-06-23 2013-04-09 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
WO2012051663A1 (en) 2010-10-21 2012-04-26 Monash University Antimicrobial compounds
WO2012168820A1 (en) 2011-06-08 2012-12-13 Pfizer Inc. Polymyxin derivatives useful as antibacterial agents
PT2999711T (pt) 2013-05-22 2022-07-29 Spero Therapeutics Inc Derivados de polimixina e a sua utilização em terapia de combinação em conjunto com antibióticos diferentes
US20170073373A1 (en) 2014-03-11 2017-03-16 New Pharma Licence Holdings Limited Polymyxin derivatives and their use in combination therapy together with different antibiotics
EP3126376B1 (en) * 2014-04-01 2024-08-21 Monash University Polymyxin derivatives as antimicrobial compounds
CN107108699A (zh) * 2014-11-26 2017-08-29 新药物许可控股有限公司 化合物
WO2016166103A1 (en) 2015-04-13 2016-10-20 Xellia Pharmaceuticals Aps Polymyxin derivatives
CN108350034B (zh) 2015-09-29 2022-03-11 莫纳什大学 抗微生物的多黏菌素衍生的化合物
LT3810633T (lt) 2018-06-25 2024-01-10 Spero Therapeutics, Inc. Junginiai

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090215677A1 (en) * 2008-02-08 2009-08-27 Martti Sakari Vaara Polymyxin derivatives and uses thereof
CN103946233A (zh) * 2011-11-18 2014-07-23 诺瓦克塔生物系统有限公司 多黏菌素衍生物

Also Published As

Publication number Publication date
US12146004B2 (en) 2024-11-19
CN107108699A (zh) 2017-08-29
EP3224273A1 (en) 2017-10-04
TW201625664A (zh) 2016-07-16
CA2968902C (en) 2023-08-29
JP2017538692A (ja) 2017-12-28
US20230340026A1 (en) 2023-10-26
CA2968902A1 (en) 2016-06-02
AU2015352440B2 (en) 2020-02-06
JP7349773B2 (ja) 2023-09-25
US20180030092A1 (en) 2018-02-01
AU2015352440A1 (en) 2017-06-29
WO2016083531A1 (en) 2016-06-02

Similar Documents

Publication Publication Date Title
TWI757229B (zh) 用於治療微生物感染的化合物以及該化合物的用途
ES2923762T3 (es) Derivados de polimixina y su uso en terapia combinado junto con diferentes antibióticos
CN106232617B (zh) 多粘菌素衍生物及其在与不同抗生素的联合疗法中的用途
US9234006B2 (en) Compounds
ES2971732T3 (es) Compuestos
EA047835B1 (ru) Соединения
BR112016020998B1 (pt) Compostos derivados de polimixina, composições farmacêuticas compreendedo os ditos compostos e usos terapêuticos dos mesmos
HK1221474B (en) Polymyxin derivatives and their use in combination therapy together with different antibiotics