TWI756299B - Magl抑制劑 - Google Patents

Magl抑制劑 Download PDF

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Publication number
TWI756299B
TWI756299B TW106139775A TW106139775A TWI756299B TW I756299 B TWI756299 B TW I756299B TW 106139775 A TW106139775 A TW 106139775A TW 106139775 A TW106139775 A TW 106139775A TW I756299 B TWI756299 B TW I756299B
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TW
Taiwan
Prior art keywords
pharmaceutically acceptable
compound
formula
solvate
acceptable salt
Prior art date
Application number
TW106139775A
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English (en)
Chinese (zh)
Other versions
TW201823216A (zh
Inventor
雪瑞兒 A 葛莉絲
丹尼爾 J 布澤德
麥可 B 賽格哈菲
Original Assignee
丹麥商Ｈ 朗德貝克公司
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Publication of TW201823216A publication Critical patent/TW201823216A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/195—Radicals derived from nitrogen analogues of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW106139775A 2016-11-16 2017-11-16 Magl抑制劑 TWI756299B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662423099P 2016-11-16 2016-11-16
US62/423,099 2016-11-16

Publications (2)

Publication Number Publication Date
TW201823216A TW201823216A (zh) 2018-07-01
TWI756299B true TWI756299B (zh) 2022-03-01

Family

ID=62106678

Family Applications (1)

Application Number Title Priority Date Filing Date
TW106139775A TWI756299B (zh) 2016-11-16 2017-11-16 Magl抑制劑

Country Status (29)

Country Link
US (1) US10093635B2 (enExample)
EP (1) EP3541821A4 (enExample)
JP (1) JP7042547B2 (enExample)
KR (1) KR20190077544A (enExample)
CN (1) CN110267963B (enExample)
AR (1) AR110089A1 (enExample)
AU (1) AU2017361251B2 (enExample)
BR (1) BR112019009994A2 (enExample)
CA (1) CA3043615A1 (enExample)
CL (1) CL2019001339A1 (enExample)
CO (1) CO2019005059A2 (enExample)
CR (1) CR20190241A (enExample)
DO (1) DOP2019000122A (enExample)
EA (1) EA038090B1 (enExample)
EC (1) ECSP19035077A (enExample)
GE (2) GEP20237470B (enExample)
IL (1) IL266523B (enExample)
JO (1) JOP20190106A1 (enExample)
MA (1) MA46857A (enExample)
MX (1) MX391117B (enExample)
NI (1) NI201900051A (enExample)
PE (1) PE20191144A1 (enExample)
PH (1) PH12019501097A1 (enExample)
RU (1) RU2754536C1 (enExample)
TN (1) TN2019000153A1 (enExample)
TW (1) TWI756299B (enExample)
UA (1) UA124542C2 (enExample)
WO (1) WO2018093947A1 (enExample)
ZA (1) ZA201903100B (enExample)

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MX2017014344A (es) 2015-05-11 2018-04-11 Abide Therapeutics Inc Metodos para el tratamiento de la inflacion o el dolor neuropatico.
US10899737B2 (en) 2016-09-19 2021-01-26 Lundbeck La Jolla Research Center, Inc. Piperazine carbamates and methods of making and using same
JOP20190107A1 (ar) 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc مثبطات أحادي أسيل جليسرول ليباز (magl)
EP3541807B1 (en) 2016-11-16 2021-09-29 H. Lundbeck A/S A crystalline form of a magl inhibitor
CN110290791A (zh) 2016-11-16 2019-09-27 灵北拉荷亚研究中心公司 药物制剂
RS64006B1 (sr) 2017-05-23 2023-03-31 H Lundbeck As Pirazol magl inhibitori
MA50041A (fr) 2017-08-29 2020-07-08 Lundbeck La Jolla Research Center Inc Composés spirocycliques et procédés de préparation et d'utilisation de ceux-ci
SG11202011228TA (en) * 2018-05-15 2020-12-30 Lundbeck La Jolla Research Center Inc Magl inhibitors
MA54827A (fr) * 2019-01-25 2022-05-04 H Lundbeck As Méthodes de traitement d'une maladie à l'aide d'inhibiteurs de magl
AU2020383502A1 (en) * 2019-11-15 2022-06-30 H. Lundbeck A/S Crystalline forms of a MAGL inhibitor
IT202000007150A1 (it) * 2020-04-03 2021-10-03 Univ Pisa Inibitori di monoacilglicerolo lipasi (magl)
WO2021214550A1 (en) 2020-04-21 2021-10-28 H. Lundbeck A/S Synthesis of a monoacylglycerol lipase inhibitor
WO2023130023A1 (en) 2021-12-29 2023-07-06 Psy Therapeutics, Inc. Inhibiting monoacylglycerol lipase (magl)
US12378219B2 (en) 2022-05-04 2025-08-05 H. Lundbeck A/S Crystalline forms of a MAGL inhibitor

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CN104159581A (zh) * 2012-01-06 2014-11-19 阿比德治疗公司 氨基甲酸酯化合物及其制备和使用方法
WO2016149401A2 (en) * 2015-03-18 2016-09-22 Abide Therapeutics, Inc. Piperazine carbamates and methods of making and using same

Also Published As

Publication number Publication date
CR20190241A (es) 2019-09-02
US10093635B2 (en) 2018-10-09
ECSP19035077A (es) 2019-05-31
UA124542C2 (uk) 2021-10-05
WO2018093947A1 (en) 2018-05-24
JOP20190106A1 (ar) 2019-05-09
DOP2019000122A (es) 2019-09-30
RU2754536C1 (ru) 2021-09-03
MX391117B (es) 2025-03-21
CN110267963A (zh) 2019-09-20
TW201823216A (zh) 2018-07-01
IL266523B (en) 2022-09-01
US20180134674A1 (en) 2018-05-17
AR110089A1 (es) 2019-02-20
PE20191144A1 (es) 2019-09-02
AU2017361251A1 (en) 2019-05-30
EP3541821A4 (en) 2020-04-22
MA46857A (fr) 2019-09-25
TN2019000153A1 (en) 2020-10-05
CA3043615A1 (en) 2018-05-24
EA038090B1 (ru) 2021-07-05
AU2017361251B2 (en) 2021-08-19
MX2019005776A (es) 2019-12-05
NI201900051A (es) 2019-10-30
EA201991073A1 (ru) 2019-12-30
CO2019005059A2 (es) 2019-05-31
GEAP202215088A (en) 2022-08-25
JP2020504707A (ja) 2020-02-13
ZA201903100B (en) 2020-11-25
RU2019116512A (ru) 2020-12-17
CN110267963B (zh) 2022-04-01
JP7042547B2 (ja) 2022-03-28
BR112019009994A2 (pt) 2019-08-27
PH12019501097A1 (en) 2019-08-19
KR20190077544A (ko) 2019-07-03
IL266523A (en) 2019-07-31
CL2019001339A1 (es) 2019-10-04
NZ753264A (en) 2020-12-18
EP3541821A1 (en) 2019-09-25
GEP20237470B (en) 2023-02-10

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