TWI736577B

TWI736577B - ５-胺基乙醯丙酸和其衍生物的鹽

５-胺基乙醯丙酸和其衍生物的鹽 Download PDF

Info

Publication number: TWI736577B
Authority: TW; Taiwan
Prior art keywords: trichloroacetate; propionate; salt; acid; salt compound
Prior art date: 2016-01-26

Application number

TW106102897A

Other languages

English (en)

Chinese (zh)

Other versions

TW201731811A (zh

Inventor

趙鳴

周麗明

Original Assignee

趙鳴

周麗明

Priority date

2016-01-26

Filing date

2017-01-25

Publication date

2021-08-21

2017-01-25 Application filed by 趙鳴, 周麗明 filed Critical 趙鳴

2017-09-16 Publication of TW201731811A publication Critical patent/TW201731811A/zh

2021-08-21 Application granted granted Critical

2021-08-21 Publication of TWI736577B publication Critical patent/TWI736577B/zh

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150000003839 salts Chemical class 0.000 title abstract description 93
ZGXJTSGNIOSYLO-UHFFFAOYSA-N 88755TAZ87 Chemical class NCC(=O)CCC(O)=O ZGXJTSGNIOSYLO-UHFFFAOYSA-N 0.000 title abstract description 48
229960002749 aminolevulinic acid Drugs 0.000 title abstract description 5
-1 salt compound Chemical class 0.000 claims description 95
239000002253 acid Substances 0.000 claims description 40
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 21
239000000546 pharmaceutical excipient Substances 0.000 claims description 16
YNJBWRMUSHSURL-UHFFFAOYSA-M trichloroacetate Chemical compound [O-]C(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-M 0.000 claims description 16
239000001257 hydrogen Substances 0.000 claims description 15
229910052739 hydrogen Inorganic materials 0.000 claims description 15
239000008194 pharmaceutical composition Substances 0.000 claims description 13
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 11
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 11
125000006503 p-nitrobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1[N+]([O-])=O)C([H])([H])* 0.000 claims description 11
125000006179 2-methyl benzyl group Chemical group [H]C1=C([H])C(=C(C([H])=C1[H])C([H])([H])*)C([H])([H])[H] 0.000 claims description 10
125000002528 4-isopropyl benzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])*)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 10
125000006283 4-chlorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])* 0.000 claims description 9
125000006181 4-methyl benzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])* 0.000 claims description 9
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 9
125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 7
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 6
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 6
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 6
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125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims description 5
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YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 59
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125000004429 atom Chemical group 0.000 description 18
125000003118 aryl group Chemical group 0.000 description 16
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 15
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QMMFVYPAHWMCMS-UHFFFAOYSA-N Dimethyl sulfide Chemical compound CSC QMMFVYPAHWMCMS-UHFFFAOYSA-N 0.000 description 6
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